Association of a dietary score with incident type 2 Diabetes: the dietary-based diabetes-risk score (DDS)
Background Strong evidence supports that dietary modifications may decrease incident type 2 diabetes mellitus (T2DM). Numerous diabetes risk models/scores have been developed, but most do not rely specifically on dietary variables or do not fully capture the overall dietary pattern. We prospecti...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Public Library of Science
2015
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| Online Access: | https://hdl.handle.net/10171/39423 |
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| author | Dominguez, L.J. (Ligia J.) Bes-Rastrollo, M. (Maira) Basterra-Gortari, F.J. (Francisco Javier) Gea, A. (Alfredo) Barbagallo, M. (Mario) Martinez-Gonzalez, M.A. (Miguel Ángel) |
| author_facet | Dominguez, L.J. (Ligia J.) Bes-Rastrollo, M. (Maira) Basterra-Gortari, F.J. (Francisco Javier) Gea, A. (Alfredo) Barbagallo, M. (Mario) Martinez-Gonzalez, M.A. (Miguel Ángel) |
| author_sort | Dominguez, L.J. (Ligia J.) |
| collection | DSpace |
| description | Background
Strong evidence supports that dietary modifications may decrease incident type 2 diabetes
mellitus (T2DM). Numerous diabetes risk models/scores have been developed, but most do
not rely specifically on dietary variables or do not fully capture the overall dietary pattern.
We prospectively assessed the association of a dietary-based diabetes-risk score (DDS),
which integrates optimal food patterns, with the risk of developing T2DM in the SUN
(“Seguimiento Universidad de Navarra”) longitudinal study.
Methods
We assessed 17,292 participants initially free of diabetes, followed-up for a mean of 9.2
years. A validated 136-item FFQ was administered at baseline. Taking into account previous
literature, the DDS positively weighted vegetables, fruit, whole cereals, nuts, coffee,
low-fat dairy, fiber, PUFA, and alcohol in moderate amounts; while it negatively weighted
red meat, processed meats and sugar-sweetened beverages. Energy-adjusted quintiles of
each item (with exception of moderate alcohol consumption that received either 0 or 5
points) were used to build the DDS (maximum: 60 points). Incident T2DM was confirmed
through additional detailed questionnaires and review of medical records of participants.
We used Cox proportional hazards models adjusted for socio-demographic and anthropometric
parameters, health-related habits, and clinical variables to estimate hazard ratios
(HR) of T2DM.
Results
We observed 143 T2DM confirmed cases during follow-up. Better baseline conformity with
the DDS was associated with lower incidence of T2DM (multivariable-adjusted HR for intermediate
(25–39 points) vs. low (11–24) category 0.43 [95% confidence interval (CI) 0.21,0.89]; and for high (40–60) vs. low category 0.32 [95% CI: 0.14, 0.69]; p for linear trend: 0.019).
Conclusions
The DDS, a simple score exclusively based on dietary components, showed a strong
inverse association with incident T2DM. This score may be applicable in clinical practice to
improve dietary habits of subjects at high risk of T2DM and also as an educational tool for
laypeople to help them in self-assessing their future risk for developing diabetes. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-39423 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2015 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-394232022-06-29T09:41:37Z Association of a dietary score with incident type 2 Diabetes: the dietary-based diabetes-risk score (DDS) Dominguez, L.J. (Ligia J.) Bes-Rastrollo, M. (Maira) Basterra-Gortari, F.J. (Francisco Javier) Gea, A. (Alfredo) Barbagallo, M. (Mario) Martinez-Gonzalez, M.A. (Miguel Ángel) Dietary modifications Type 2 diabetes mellitus Chronic disease Mortality Background Strong evidence supports that dietary modifications may decrease incident type 2 diabetes mellitus (T2DM). Numerous diabetes risk models/scores have been developed, but most do not rely specifically on dietary variables or do not fully capture the overall dietary pattern. We prospectively assessed the association of a dietary-based diabetes-risk score (DDS), which integrates optimal food patterns, with the risk of developing T2DM in the SUN (“Seguimiento Universidad de Navarra”) longitudinal study. Methods We assessed 17,292 participants initially free of diabetes, followed-up for a mean of 9.2 years. A validated 136-item FFQ was administered at baseline. Taking into account previous literature, the DDS positively weighted vegetables, fruit, whole cereals, nuts, coffee, low-fat dairy, fiber, PUFA, and alcohol in moderate amounts; while it negatively weighted red meat, processed meats and sugar-sweetened beverages. Energy-adjusted quintiles of each item (with exception of moderate alcohol consumption that received either 0 or 5 points) were used to build the DDS (maximum: 60 points). Incident T2DM was confirmed through additional detailed questionnaires and review of medical records of participants. We used Cox proportional hazards models adjusted for socio-demographic and anthropometric parameters, health-related habits, and clinical variables to estimate hazard ratios (HR) of T2DM. Results We observed 143 T2DM confirmed cases during follow-up. Better baseline conformity with the DDS was associated with lower incidence of T2DM (multivariable-adjusted HR for intermediate (25–39 points) vs. low (11–24) category 0.43 [95% confidence interval (CI) 0.21,0.89]; and for high (40–60) vs. low category 0.32 [95% CI: 0.14, 0.69]; p for linear trend: 0.019). Conclusions The DDS, a simple score exclusively based on dietary components, showed a strong inverse association with incident T2DM. This score may be applicable in clinical practice to improve dietary habits of subjects at high risk of T2DM and also as an educational tool for laypeople to help them in self-assessing their future risk for developing diabetes. 2015-11-19T15:49:32Z 2015-11-19T15:49:32Z 2015 info:eu-repo/semantics/article https://hdl.handle.net/10171/39423 eng info:eu-repo/semantics/openAccess application/pdf Public Library of Science |
| spellingShingle | Dietary modifications Type 2 diabetes mellitus Chronic disease Mortality Dominguez, L.J. (Ligia J.) Bes-Rastrollo, M. (Maira) Basterra-Gortari, F.J. (Francisco Javier) Gea, A. (Alfredo) Barbagallo, M. (Mario) Martinez-Gonzalez, M.A. (Miguel Ángel) Association of a dietary score with incident type 2 Diabetes: the dietary-based diabetes-risk score (DDS) |
| title | Association of a dietary score with incident type 2 Diabetes: the dietary-based diabetes-risk score (DDS) |
| title_full | Association of a dietary score with incident type 2 Diabetes: the dietary-based diabetes-risk score (DDS) |
| title_fullStr | Association of a dietary score with incident type 2 Diabetes: the dietary-based diabetes-risk score (DDS) |
| title_full_unstemmed | Association of a dietary score with incident type 2 Diabetes: the dietary-based diabetes-risk score (DDS) |
| title_short | Association of a dietary score with incident type 2 Diabetes: the dietary-based diabetes-risk score (DDS) |
| title_sort | association of a dietary score with incident type 2 diabetes: the dietary-based diabetes-risk score (dds) |
| topic | Dietary modifications Type 2 diabetes mellitus Chronic disease Mortality |
| url | https://hdl.handle.net/10171/39423 |
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