FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials
Objective To assess the effect of the FTO genotype on weight loss after dietary, physical activity, or drug based interventions in randomised controlled trials. Design Systematic review and random effects meta-analysis of individual participant data from randomised controlled trials. Data so...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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BMJ
2016
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/41864 |
| _version_ | 1793400129908113408 |
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| author | Livingstone, K.M. (Katherine M.) Celis-Morales, C. (Carlos) Papandonatos, G.D. (George D.) Erar, B. (Bahar) Florez, J.C. (Jose C.) Jablonski, K.A. (Kathleen A.) Razquin, C. (Cristina) Marti-del-Moral, A. (Amelia) Heianza, Y. (Yoriko) Huang, T. (Tao) Sacks, F.M. (Frank M.) Svendstrup, M. (Mathilde) Sui, X. (Xuemei) Church, T.S. (Timothy S.) Jääskeläinen, T. (Tiina) Lindström, J. (Jaana) Tuomilehto, J. (Jaakko) Uusitupa, M. (Matti) Rankinen, T. (Tuomo) Saris, W.H.M. (Wim H. M.) Hansen, T. (Torben) Pedersen, O. (Oluf) Astrup, A. (Arne) Sørensen, T.I.A (Thorkild I. A.) Qi, L. (Lu) Bray, G.A. (George A.) Martinez-Gonzalez, M.A. (Miguel Ángel) Martinez, J.A. (José Alfredo) Franks, P.W. (Paul W.) McCaffery, J.M. (Jeanne M.) Lara, J. (Jose) Mathers, J.C. (John C.) |
| author_facet | Livingstone, K.M. (Katherine M.) Celis-Morales, C. (Carlos) Papandonatos, G.D. (George D.) Erar, B. (Bahar) Florez, J.C. (Jose C.) Jablonski, K.A. (Kathleen A.) Razquin, C. (Cristina) Marti-del-Moral, A. (Amelia) Heianza, Y. (Yoriko) Huang, T. (Tao) Sacks, F.M. (Frank M.) Svendstrup, M. (Mathilde) Sui, X. (Xuemei) Church, T.S. (Timothy S.) Jääskeläinen, T. (Tiina) Lindström, J. (Jaana) Tuomilehto, J. (Jaakko) Uusitupa, M. (Matti) Rankinen, T. (Tuomo) Saris, W.H.M. (Wim H. M.) Hansen, T. (Torben) Pedersen, O. (Oluf) Astrup, A. (Arne) Sørensen, T.I.A (Thorkild I. A.) Qi, L. (Lu) Bray, G.A. (George A.) Martinez-Gonzalez, M.A. (Miguel Ángel) Martinez, J.A. (José Alfredo) Franks, P.W. (Paul W.) McCaffery, J.M. (Jeanne M.) Lara, J. (Jose) Mathers, J.C. (John C.) |
| author_sort | Livingstone, K.M. (Katherine M.) |
| collection | DSpace |
| description | Objective
To assess the effect of the FTO genotype on weight loss
after dietary, physical activity, or drug based
interventions in randomised controlled trials.
Design
Systematic review and random effects meta-analysis
of individual participant data from randomised
controlled trials.
Data sources
Ovid Medline, Scopus, Embase, and Cochrane from
inception to November 2015.
Eligibility criteria for study selection
Randomised controlled trials in overweight or obese
adults reporting reduction in body mass index, body
weight, or waist circumference by FTO genotype
(rs9939609 or a proxy) after dietary, physical activity,
or drug based interventions. Gene by treatment
interaction models were fitted to individual participant
data from all studies included in this review, using
allele dose coding for genetic effects and a common
set of covariates. Study level interactions were
combined using random effect models.
Metaregression and subgroup analysis were used to
assess sources of study heterogeneity.
Results
We identified eight eligible randomised controlled trials
for the systematic review and meta-analysis (n=9563).
Overall, differential changes in body mass index, body
weight, and waist circumference in response to weight
loss intervention were not significantly different
between FTO genotypes. Sensitivity analyses indicated
that differential changes in body mass index, body
weight, and waist circumference by FTO genotype did
not differ by intervention type, intervention length,
ethnicity, sample size, sex, and baseline body mass
index and age category.
Conclusions
We have observed that carriage of the FTO minor allele
was not associated with differential change in
adiposity after weight loss interventions. These
findings show that individuals carrying the minor allele
respond equally well to dietary, physical activity, or
drug based weight loss interventions and thus genetic
predisposition to obesity associated with the FTO
minor allele can be at least partly counteracted
through such interventions.
Systematic review registration
PROSPERO CRD42015015969. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-41864 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2016 |
| publisher | BMJ |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-418642024-01-24T08:58:37Z FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials Livingstone, K.M. (Katherine M.) Celis-Morales, C. (Carlos) Papandonatos, G.D. (George D.) Erar, B. (Bahar) Florez, J.C. (Jose C.) Jablonski, K.A. (Kathleen A.) Razquin, C. (Cristina) Marti-del-Moral, A. (Amelia) Heianza, Y. (Yoriko) Huang, T. (Tao) Sacks, F.M. (Frank M.) Svendstrup, M. (Mathilde) Sui, X. (Xuemei) Church, T.S. (Timothy S.) Jääskeläinen, T. (Tiina) Lindström, J. (Jaana) Tuomilehto, J. (Jaakko) Uusitupa, M. (Matti) Rankinen, T. (Tuomo) Saris, W.H.M. (Wim H. M.) Hansen, T. (Torben) Pedersen, O. (Oluf) Astrup, A. (Arne) Sørensen, T.I.A (Thorkild I. A.) Qi, L. (Lu) Bray, G.A. (George A.) Martinez-Gonzalez, M.A. (Miguel Ángel) Martinez, J.A. (José Alfredo) Franks, P.W. (Paul W.) McCaffery, J.M. (Jeanne M.) Lara, J. (Jose) Mathers, J.C. (John C.) FTO genotype Weight loss Randomised controlled trials Materias Investigacion::Ciencias de la Salud::Nutrición y dietética Materias Investigacion::Ciencias de la Salud::Medicina preventiva Objective To assess the effect of the FTO genotype on weight loss after dietary, physical activity, or drug based interventions in randomised controlled trials. Design Systematic review and random effects meta-analysis of individual participant data from randomised controlled trials. Data sources Ovid Medline, Scopus, Embase, and Cochrane from inception to November 2015. Eligibility criteria for study selection Randomised controlled trials in overweight or obese adults reporting reduction in body mass index, body weight, or waist circumference by FTO genotype (rs9939609 or a proxy) after dietary, physical activity, or drug based interventions. Gene by treatment interaction models were fitted to individual participant data from all studies included in this review, using allele dose coding for genetic effects and a common set of covariates. Study level interactions were combined using random effect models. Metaregression and subgroup analysis were used to assess sources of study heterogeneity. Results We identified eight eligible randomised controlled trials for the systematic review and meta-analysis (n=9563). Overall, differential changes in body mass index, body weight, and waist circumference in response to weight loss intervention were not significantly different between FTO genotypes. Sensitivity analyses indicated that differential changes in body mass index, body weight, and waist circumference by FTO genotype did not differ by intervention type, intervention length, ethnicity, sample size, sex, and baseline body mass index and age category. Conclusions We have observed that carriage of the FTO minor allele was not associated with differential change in adiposity after weight loss interventions. These findings show that individuals carrying the minor allele respond equally well to dietary, physical activity, or drug based weight loss interventions and thus genetic predisposition to obesity associated with the FTO minor allele can be at least partly counteracted through such interventions. Systematic review registration PROSPERO CRD42015015969. 2016-10-18T10:32:47Z 2016-10-18T10:32:47Z 2016 info:eu-repo/semantics/article https://hdl.handle.net/10171/41864 eng info:eu-repo/grantAgreement/EC/FP7/265494 info:eu-repo/semantics/openAccess application/pdf BMJ |
| spellingShingle | FTO genotype Weight loss Randomised controlled trials Materias Investigacion::Ciencias de la Salud::Nutrición y dietética Materias Investigacion::Ciencias de la Salud::Medicina preventiva Livingstone, K.M. (Katherine M.) Celis-Morales, C. (Carlos) Papandonatos, G.D. (George D.) Erar, B. (Bahar) Florez, J.C. (Jose C.) Jablonski, K.A. (Kathleen A.) Razquin, C. (Cristina) Marti-del-Moral, A. (Amelia) Heianza, Y. (Yoriko) Huang, T. (Tao) Sacks, F.M. (Frank M.) Svendstrup, M. (Mathilde) Sui, X. (Xuemei) Church, T.S. (Timothy S.) Jääskeläinen, T. (Tiina) Lindström, J. (Jaana) Tuomilehto, J. (Jaakko) Uusitupa, M. (Matti) Rankinen, T. (Tuomo) Saris, W.H.M. (Wim H. M.) Hansen, T. (Torben) Pedersen, O. (Oluf) Astrup, A. (Arne) Sørensen, T.I.A (Thorkild I. A.) Qi, L. (Lu) Bray, G.A. (George A.) Martinez-Gonzalez, M.A. (Miguel Ángel) Martinez, J.A. (José Alfredo) Franks, P.W. (Paul W.) McCaffery, J.M. (Jeanne M.) Lara, J. (Jose) Mathers, J.C. (John C.) FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials |
| title | FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials |
| title_full | FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials |
| title_fullStr | FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials |
| title_full_unstemmed | FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials |
| title_short | FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials |
| title_sort | fto genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials |
| topic | FTO genotype Weight loss Randomised controlled trials Materias Investigacion::Ciencias de la Salud::Nutrición y dietética Materias Investigacion::Ciencias de la Salud::Medicina preventiva |
| url | https://hdl.handle.net/10171/41864 |
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