Metabolites of glutamate metabolism are associated with incident cardiovascular events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) trial
Glutamate metabolism may play a role in the pathophysiology of cardiometabolic disorders. However, there is limited evidence of an association between glutamate-related metabolites and, moreover, changes in these metabolites, and risk of cardiovascular disease (CVD). Methods and Results-—Plasma l...
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| Format: | info:eu-repo/semantics/article |
| Language: | spa |
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American Heart Association
2017
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| Online Access: | https://hdl.handle.net/10171/43268 |
| _version_ | 1793400130151383040 |
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| author | Zheng, Y. (Yan) Hu, F.B. (Frank B.) Ruiz-Canela, M. (Miguel) Clish, C.B. (Clary B.) Dennis, C. (Courtney) Salas-Salvado, J. (Jordi) Hruby, A. (Adela) Liang, L. (Liming) Toledo, E. (Estefanía) Corella, D. (Dolores) Ros, E. (Emilio) Fito, M. (Montserrat) Gomez-Gracia, E. (Enrique) Aros, F. (Fernando) Fiol, M. (Miquel) Lapetra, J. (José) Serra-Majem, L. (Luis) Estruch, R. (Ramón) Martinez-Gonzalez, M.A. (Miguel Ángel) |
| author_facet | Zheng, Y. (Yan) Hu, F.B. (Frank B.) Ruiz-Canela, M. (Miguel) Clish, C.B. (Clary B.) Dennis, C. (Courtney) Salas-Salvado, J. (Jordi) Hruby, A. (Adela) Liang, L. (Liming) Toledo, E. (Estefanía) Corella, D. (Dolores) Ros, E. (Emilio) Fito, M. (Montserrat) Gomez-Gracia, E. (Enrique) Aros, F. (Fernando) Fiol, M. (Miquel) Lapetra, J. (José) Serra-Majem, L. (Luis) Estruch, R. (Ramón) Martinez-Gonzalez, M.A. (Miguel Ángel) |
| author_sort | Zheng, Y. (Yan) |
| collection | DSpace |
| description | Glutamate metabolism may play a role in the pathophysiology of cardiometabolic disorders. However, there is
limited evidence of an association between glutamate-related metabolites and, moreover, changes in these metabolites, and risk of
cardiovascular disease (CVD).
Methods and Results-—Plasma levels of glutamate and glutamine were measured at baseline and 1-year follow-up in a case-cohort
study including 980 participants (mean age 68 years; 46% male) from the PREvenci on con DIeta MEDiterr anea (PREDIMED)
randomized trial, which assessed a Mediterranean diet intervention in the primary prevention of CVD. During median 4.8 years of
follow-up, there were 229 incident CVD events (nonfatal stroke, nonfatal myocardial infarction, or CVD death). In fully adjusted
models, per 1-SD, baseline glutamate was associated with 43% (95% CI: 16% to 76%) and 81% (39% to 137%) increased risk of
composite CVD and stroke alone, respectively, and baseline glutamine-to-glutamate ratio with 25% (6% to 40%) and 44% (25%
to 58%) decreased risk of composite CVD and stroke alone, respectively. Associations appeared linear for stroke (both
Plinear trend≤0.005). Among participants with high baseline glutamate, the interventions lowered CVD risk by 37% compared to
the control diet; the intervention effects were not significant when baseline glutamate was low (Pinteraction=0.02). No significant
effect of the intervention on year-1 changes in metabolites was observed, and no effect of changes themselves on CVD risk was
apparent.
Conclusions-—Baseline glutamate was associated with increased CVD risk, particularly stroke, and glutamine-to-glutamate ratio
was associated with decreased risk. Participants with high glutamate levels may obtain greater benefits from the Mediterranean
diet than those with low levels. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-43268 |
| institution | Universidad de Navarra |
| language | spa |
| publishDate | 2017 |
| publisher | American Heart Association |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-432682023-03-13T11:03:59Z Metabolites of glutamate metabolism are associated with incident cardiovascular events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) trial Zheng, Y. (Yan) Hu, F.B. (Frank B.) Ruiz-Canela, M. (Miguel) Clish, C.B. (Clary B.) Dennis, C. (Courtney) Salas-Salvado, J. (Jordi) Hruby, A. (Adela) Liang, L. (Liming) Toledo, E. (Estefanía) Corella, D. (Dolores) Ros, E. (Emilio) Fito, M. (Montserrat) Gomez-Gracia, E. (Enrique) Aros, F. (Fernando) Fiol, M. (Miquel) Lapetra, J. (José) Serra-Majem, L. (Luis) Estruch, R. (Ramón) Martinez-Gonzalez, M.A. (Miguel Ángel) Materias Investigacion::Ciencias de la Salud::Salud pública Cardiovascular disease Diet Dietary clinical trial Epidemiology Glutamate Incidence Stroke Glutamate metabolism may play a role in the pathophysiology of cardiometabolic disorders. However, there is limited evidence of an association between glutamate-related metabolites and, moreover, changes in these metabolites, and risk of cardiovascular disease (CVD). Methods and Results-—Plasma levels of glutamate and glutamine were measured at baseline and 1-year follow-up in a case-cohort study including 980 participants (mean age 68 years; 46% male) from the PREvenci on con DIeta MEDiterr anea (PREDIMED) randomized trial, which assessed a Mediterranean diet intervention in the primary prevention of CVD. During median 4.8 years of follow-up, there were 229 incident CVD events (nonfatal stroke, nonfatal myocardial infarction, or CVD death). In fully adjusted models, per 1-SD, baseline glutamate was associated with 43% (95% CI: 16% to 76%) and 81% (39% to 137%) increased risk of composite CVD and stroke alone, respectively, and baseline glutamine-to-glutamate ratio with 25% (6% to 40%) and 44% (25% to 58%) decreased risk of composite CVD and stroke alone, respectively. Associations appeared linear for stroke (both Plinear trend≤0.005). Among participants with high baseline glutamate, the interventions lowered CVD risk by 37% compared to the control diet; the intervention effects were not significant when baseline glutamate was low (Pinteraction=0.02). No significant effect of the intervention on year-1 changes in metabolites was observed, and no effect of changes themselves on CVD risk was apparent. Conclusions-—Baseline glutamate was associated with increased CVD risk, particularly stroke, and glutamine-to-glutamate ratio was associated with decreased risk. Participants with high glutamate levels may obtain greater benefits from the Mediterranean diet than those with low levels. 2017-05-02T10:09:25Z 2017-05-02T10:09:25Z 2016 info:eu-repo/semantics/article https://hdl.handle.net/10171/43268 spa info:eu-repo/grantAgreement/NIH/FP7/1R01HL118264-01 info:eu-repo/semantics/openAccess application/pdf American Heart Association |
| spellingShingle | Materias Investigacion::Ciencias de la Salud::Salud pública Cardiovascular disease Diet Dietary clinical trial Epidemiology Glutamate Incidence Stroke Zheng, Y. (Yan) Hu, F.B. (Frank B.) Ruiz-Canela, M. (Miguel) Clish, C.B. (Clary B.) Dennis, C. (Courtney) Salas-Salvado, J. (Jordi) Hruby, A. (Adela) Liang, L. (Liming) Toledo, E. (Estefanía) Corella, D. (Dolores) Ros, E. (Emilio) Fito, M. (Montserrat) Gomez-Gracia, E. (Enrique) Aros, F. (Fernando) Fiol, M. (Miquel) Lapetra, J. (José) Serra-Majem, L. (Luis) Estruch, R. (Ramón) Martinez-Gonzalez, M.A. (Miguel Ángel) Metabolites of glutamate metabolism are associated with incident cardiovascular events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) trial |
| title | Metabolites of glutamate metabolism are associated with incident cardiovascular events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) trial |
| title_full | Metabolites of glutamate metabolism are associated with incident cardiovascular events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) trial |
| title_fullStr | Metabolites of glutamate metabolism are associated with incident cardiovascular events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) trial |
| title_full_unstemmed | Metabolites of glutamate metabolism are associated with incident cardiovascular events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) trial |
| title_short | Metabolites of glutamate metabolism are associated with incident cardiovascular events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) trial |
| title_sort | metabolites of glutamate metabolism are associated with incident cardiovascular events in the predimed prevención con dieta mediterránea (predimed) trial |
| topic | Materias Investigacion::Ciencias de la Salud::Salud pública Cardiovascular disease Diet Dietary clinical trial Epidemiology Glutamate Incidence Stroke |
| url | https://hdl.handle.net/10171/43268 |
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