Pharmacokinetic/Pharmacodynamic Modelling-Based Translational Approach applied to the Anticancer Drug Gemcitabine in Advanced Pancreatic and Ovarian Cancer
This thesis performs a retrospective evaluation of data generated for the cytotoxic/cytostatic antimetabolite drug gemcitabine along the different phases of drug development. Using these data, and through data analysis and simulations-based translational exercise, a model-based framework in oncol...
| Main Authors: | , |
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| Format: | info:eu-repo/semantics/doctoralThesis |
| Language: | eng |
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2017
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/44870 |
| _version_ | 1793400459786977280 |
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| author | García-Cremades, M. (María) Troconiz, I.F. (Iñaki F.) |
| author_facet | García-Cremades, M. (María) Troconiz, I.F. (Iñaki F.) |
| author_sort | García-Cremades, M. (María) |
| collection | DSpace |
| description | This thesis performs a retrospective evaluation of data generated for the
cytotoxic/cytostatic antimetabolite drug gemcitabine along the different phases of drug
development. Using these data, and through data analysis and simulations-based translational
exercise, a model-based framework in oncology, relating in vitro and in vivo pre-clinical
pharmacokinetic (PK) and tumour size (TS) information, with response outcome obtained in
clinical trials, has been developed. |
| format | info:eu-repo/semantics/doctoralThesis |
| id | oai:dadun.unav.edu:10171-44870 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2017 |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-448702023-04-17T05:03:02Z Pharmacokinetic/Pharmacodynamic Modelling-Based Translational Approach applied to the Anticancer Drug Gemcitabine in Advanced Pancreatic and Ovarian Cancer García-Cremades, M. (María) Troconiz, I.F. (Iñaki F.) Materias Investigacion::Farmacia::Farmacia y farmacología Pharmacometrics This thesis performs a retrospective evaluation of data generated for the cytotoxic/cytostatic antimetabolite drug gemcitabine along the different phases of drug development. Using these data, and through data analysis and simulations-based translational exercise, a model-based framework in oncology, relating in vitro and in vivo pre-clinical pharmacokinetic (PK) and tumour size (TS) information, with response outcome obtained in clinical trials, has been developed. 2017-11-16T12:11:44Z 2017-11-16T12:11:44Z 2017-11-14 2017-09-29 info:eu-repo/semantics/doctoralThesis https://hdl.handle.net/10171/44870 eng info:eu-repo/semantics/openAccess application/pdf |
| spellingShingle | Materias Investigacion::Farmacia::Farmacia y farmacología Pharmacometrics García-Cremades, M. (María) Troconiz, I.F. (Iñaki F.) Pharmacokinetic/Pharmacodynamic Modelling-Based Translational Approach applied to the Anticancer Drug Gemcitabine in Advanced Pancreatic and Ovarian Cancer |
| title | Pharmacokinetic/Pharmacodynamic Modelling-Based Translational Approach applied to the Anticancer Drug Gemcitabine in Advanced Pancreatic and Ovarian Cancer |
| title_full | Pharmacokinetic/Pharmacodynamic Modelling-Based Translational Approach applied to the Anticancer Drug Gemcitabine in Advanced Pancreatic and Ovarian Cancer |
| title_fullStr | Pharmacokinetic/Pharmacodynamic Modelling-Based Translational Approach applied to the Anticancer Drug Gemcitabine in Advanced Pancreatic and Ovarian Cancer |
| title_full_unstemmed | Pharmacokinetic/Pharmacodynamic Modelling-Based Translational Approach applied to the Anticancer Drug Gemcitabine in Advanced Pancreatic and Ovarian Cancer |
| title_short | Pharmacokinetic/Pharmacodynamic Modelling-Based Translational Approach applied to the Anticancer Drug Gemcitabine in Advanced Pancreatic and Ovarian Cancer |
| title_sort | pharmacokinetic/pharmacodynamic modelling-based translational approach applied to the anticancer drug gemcitabine in advanced pancreatic and ovarian cancer |
| topic | Materias Investigacion::Farmacia::Farmacia y farmacología Pharmacometrics |
| url | https://hdl.handle.net/10171/44870 |
| work_keys_str_mv | AT garciacremadesmmaria pharmacokineticpharmacodynamicmodellingbasedtranslationalapproachappliedtotheanticancerdruggemcitabineinadvancedpancreaticandovariancancer AT troconizifinakif pharmacokineticpharmacodynamicmodellingbasedtranslationalapproachappliedtotheanticancerdruggemcitabineinadvancedpancreaticandovariancancer |