Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study
Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health benefits. In addition, nutrigenetic studies have explained some individual variations in the response to specific dietary patterns. The present research aimed to explore associations and potential interactions betwe...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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2017
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| Online Access: | https://hdl.handle.net/10171/44951 |
| _version_ | 1793400130387312640 |
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| author | San-Cristobal, R. (Rodrigo) Navas-Carretero, S. (Santiago) Livingstone, K.M. (Katherine M.) Celis-Morales, C. (Carlos) Macready, A.L. (Anna L.) Fallaize, R. (Rosalind) Lambrinou, C.P. (Christina Paulina) Moschonis, G. (George) Marsaux, C.F.M. (Cyril F. M.) Manios, Y. (Yannis) Jarosz, M. (Miroslaw) Daniel, H. (Hannelore) Gibney, E.R. (Eileen R.) Brennan, L. (Lorraine) Drevon, C.A (Christian A) Gundersen, T.E. (Thomas E) Gibney, M.J. (M.J.) Saris, W.H.M. (Wim H. M.) Lovegrove, J. A. (Julie A.) Grimaldi, K. (Keith) Parnell, L.D. (Laurence D) Bouwman, J. (Jildau) Van Ommen, B. (Ben) Mathers, J.C. (John C.) Martinez, J.A. (José Alfredo) |
| author_facet | San-Cristobal, R. (Rodrigo) Navas-Carretero, S. (Santiago) Livingstone, K.M. (Katherine M.) Celis-Morales, C. (Carlos) Macready, A.L. (Anna L.) Fallaize, R. (Rosalind) Lambrinou, C.P. (Christina Paulina) Moschonis, G. (George) Marsaux, C.F.M. (Cyril F. M.) Manios, Y. (Yannis) Jarosz, M. (Miroslaw) Daniel, H. (Hannelore) Gibney, E.R. (Eileen R.) Brennan, L. (Lorraine) Drevon, C.A (Christian A) Gundersen, T.E. (Thomas E) Gibney, M.J. (M.J.) Saris, W.H.M. (Wim H. M.) Lovegrove, J. A. (Julie A.) Grimaldi, K. (Keith) Parnell, L.D. (Laurence D) Bouwman, J. (Jildau) Van Ommen, B. (Ben) Mathers, J.C. (John C.) Martinez, J.A. (José Alfredo) |
| author_sort | San-Cristobal, R. (Rodrigo) |
| collection | DSpace |
| description | Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health
benefits. In addition, nutrigenetic studies have explained some individual variations in the response to
specific dietary patterns. The present research aimed to explore associations and potential interactions
between MedDiet adherence and genetic background throughout the Food4Me web-based nutritional
intervention. Dietary, anthropometrical and biochemical data from volunteers of the Food4Me study were collected at baseline and after 6 months. Several genetic variants related to metabolic risk features
were also analysed. A Genetic Risk Score (GRS) was derived from risk alleles and a Mediterranean
Diet Score (MDS), based on validated food intake data, was estimated. At baseline, there were no
interactions between GRS and MDS categories for metabolic traits. Linear mixed model repeated
measures analyses showed a significantly greater decrease in total cholesterol in participants with a
low GRS after a 6-month period, compared to those with a high GRS. Meanwhile, a high baseline
MDS was associated with greater decreases in Body Mass Index (BMI), waist circumference and
glucose. There also was a significant interaction between GRS and the MedDiet after the follow-up
period. Among subjects with a high GRS, those with a high MDS evidenced a highly significant
reduction in total carotenoids, while among those with a low GRS, there was no difference associated
with MDS levels. These results suggest that a higher MedDiet adherence induces beneficial effects on
metabolic outcomes, which can be affected by the genetic background in some specific markers. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-44951 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2017 |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-449512022-11-07T07:31:53Z Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study San-Cristobal, R. (Rodrigo) Navas-Carretero, S. (Santiago) Livingstone, K.M. (Katherine M.) Celis-Morales, C. (Carlos) Macready, A.L. (Anna L.) Fallaize, R. (Rosalind) Lambrinou, C.P. (Christina Paulina) Moschonis, G. (George) Marsaux, C.F.M. (Cyril F. M.) Manios, Y. (Yannis) Jarosz, M. (Miroslaw) Daniel, H. (Hannelore) Gibney, E.R. (Eileen R.) Brennan, L. (Lorraine) Drevon, C.A (Christian A) Gundersen, T.E. (Thomas E) Gibney, M.J. (M.J.) Saris, W.H.M. (Wim H. M.) Lovegrove, J. A. (Julie A.) Grimaldi, K. (Keith) Parnell, L.D. (Laurence D) Bouwman, J. (Jildau) Van Ommen, B. (Ben) Mathers, J.C. (John C.) Martinez, J.A. (José Alfredo) Food4Me study Mediterranean diet Genetic risk Obesity Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health benefits. In addition, nutrigenetic studies have explained some individual variations in the response to specific dietary patterns. The present research aimed to explore associations and potential interactions between MedDiet adherence and genetic background throughout the Food4Me web-based nutritional intervention. Dietary, anthropometrical and biochemical data from volunteers of the Food4Me study were collected at baseline and after 6 months. Several genetic variants related to metabolic risk features were also analysed. A Genetic Risk Score (GRS) was derived from risk alleles and a Mediterranean Diet Score (MDS), based on validated food intake data, was estimated. At baseline, there were no interactions between GRS and MDS categories for metabolic traits. Linear mixed model repeated measures analyses showed a significantly greater decrease in total cholesterol in participants with a low GRS after a 6-month period, compared to those with a high GRS. Meanwhile, a high baseline MDS was associated with greater decreases in Body Mass Index (BMI), waist circumference and glucose. There also was a significant interaction between GRS and the MedDiet after the follow-up period. Among subjects with a high GRS, those with a high MDS evidenced a highly significant reduction in total carotenoids, while among those with a low GRS, there was no difference associated with MDS levels. These results suggest that a higher MedDiet adherence induces beneficial effects on metabolic outcomes, which can be affected by the genetic background in some specific markers. 2017-11-30T16:42:45Z 2017-11-30T16:42:45Z 2017 info:eu-repo/semantics/article https://hdl.handle.net/10171/44951 eng info:eu-repo/grantAgreement/EC/FP7/265494 info:eu-repo/semantics/openAccess application/pdf |
| spellingShingle | Food4Me study Mediterranean diet Genetic risk Obesity San-Cristobal, R. (Rodrigo) Navas-Carretero, S. (Santiago) Livingstone, K.M. (Katherine M.) Celis-Morales, C. (Carlos) Macready, A.L. (Anna L.) Fallaize, R. (Rosalind) Lambrinou, C.P. (Christina Paulina) Moschonis, G. (George) Marsaux, C.F.M. (Cyril F. M.) Manios, Y. (Yannis) Jarosz, M. (Miroslaw) Daniel, H. (Hannelore) Gibney, E.R. (Eileen R.) Brennan, L. (Lorraine) Drevon, C.A (Christian A) Gundersen, T.E. (Thomas E) Gibney, M.J. (M.J.) Saris, W.H.M. (Wim H. M.) Lovegrove, J. A. (Julie A.) Grimaldi, K. (Keith) Parnell, L.D. (Laurence D) Bouwman, J. (Jildau) Van Ommen, B. (Ben) Mathers, J.C. (John C.) Martinez, J.A. (José Alfredo) Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study |
| title | Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study |
| title_full | Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study |
| title_fullStr | Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study |
| title_full_unstemmed | Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study |
| title_short | Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study |
| title_sort | mediterranean diet adherence and genetic background roles within a web-based nutritional intervention: the food4me study |
| topic | Food4Me study Mediterranean diet Genetic risk Obesity |
| url | https://hdl.handle.net/10171/44951 |
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