| Summary: | Overweight and obesity have been steadily increasing in recent years and currently
represent a serious threat to public health. Few human studies have investigated the relationship
between polyphenol intake and body weight. Our aim was to assess the relationship between urinary
polyphenol levels and body weight. A cross-sectional study was performed with 573 participants
from the PREDIMED (Prevención con Dieta Mediterránea) trial (ISRCTN35739639). Total polyphenol
levels were measured by a reliable biomarker, total urinary polyphenol excretion (TPE), determined
by the Folin-Ciocalteu method in urine samples. Participants were categorized into five groups
according to their TPE at the fifth year. Multiple linear regression models were used to assess the
relationships between TPE and obesity parameters; body weight (BW), body mass index (BMI),
waist circumference (WC), and waist-to-height ratio (WHtR). After a five years follow up, significant
inverse correlations were observed between TPE at the 5th year and BW (β = −1.004; 95% CI: −1.634
to −0.375, p = 0.002), BMI (β = −0.320; 95% CI: −0.541 to −0.098, p = 0.005), WC (β = −0.742; 95% CI:
−1.326 to −0.158, p = 0.013), and WHtR (β = −0.408; 95% CI: −0.788 to −0.028, p = 0.036) after
adjustments for potential confounders. To conclude, a greater polyphenol intake may thus contribute
to reducing body weight in elderly people at high cardiovascular risk.
Nutrients 2017, 9, 452; doi:10.3390/nu9050452
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