Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis
There is limited evidence from epidemiological studies for the inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Therefore, this study examined associations between baseline (n = 282) and 1-year (n = 143) changes in the levels of fatty acids in blood cell membranes...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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MDPI AG
2021
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| Online Access: | https://hdl.handle.net/10171/62035 |
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| author | Muralidharan, J. (Jananee) Papandreou, C. (Christopher) Sala-Vila, A. (Aleix) Rosique-Esteban, N. (Nuria) Fito, M. (Montserrat) Estruch, R. (Ramón) Martinez-Gonzalez, M.A. (Miguel Ángel) Corella, D. (Dolores) Ros, E. (Emilio) Razquin, C. (Cristina) Castañer, O. (Olga) Salas-Salvado, J. (Jordi) Bullo, M. (Monica) |
| author_facet | Muralidharan, J. (Jananee) Papandreou, C. (Christopher) Sala-Vila, A. (Aleix) Rosique-Esteban, N. (Nuria) Fito, M. (Montserrat) Estruch, R. (Ramón) Martinez-Gonzalez, M.A. (Miguel Ángel) Corella, D. (Dolores) Ros, E. (Emilio) Razquin, C. (Cristina) Castañer, O. (Olga) Salas-Salvado, J. (Jordi) Bullo, M. (Monica) |
| author_sort | Muralidharan, J. (Jananee) |
| collection | DSpace |
| description | There is limited evidence from epidemiological studies for the inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Therefore, this study examined associations between baseline (n = 282) and 1-year (n = 143) changes in the levels of fatty acids in blood cell membranes with circulating inflammatory markers in older adults at high cardiovascular risk. The data for this cross-sectional analysis was obtained from a case-control study within the PREDIMED study. Linear regression with elastic net penalty was applied to test associations between measured fatty acids and inflammatory markers. Several fatty acids were associated with interferon-γ (IFNγ) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year. Omega-6 fatty acids were consistently positively associated with pro-inflammatory IL-6 and IL-8 at baseline. Omega-3 fatty acids including C20:5n3 and C18:3n3 were negatively associated with IFN-γ at 1 year. It is interesting to note that the cis and trans forms of C16:1n7 at 1 year were oppositely associated with the inflammatory markers. C16:1n7trans was negatively associated with IFN-γ, IL-6, IL-8, IL-10, and IL-1b, whereas C16:1n7cis was positively associated with IL-1b. This study adds to the growing body of evidence suggesting potential differences in inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-62035 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2021 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-620352022-06-29T09:41:40Z Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis Muralidharan, J. (Jananee) Papandreou, C. (Christopher) Sala-Vila, A. (Aleix) Rosique-Esteban, N. (Nuria) Fito, M. (Montserrat) Estruch, R. (Ramón) Martinez-Gonzalez, M.A. (Miguel Ángel) Corella, D. (Dolores) Ros, E. (Emilio) Razquin, C. (Cristina) Castañer, O. (Olga) Salas-Salvado, J. (Jordi) Bullo, M. (Monica) Materias Investigacion::Ciencias de la Salud::Medicina preventiva Cell membranes Fatty acids Inflammation There is limited evidence from epidemiological studies for the inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Therefore, this study examined associations between baseline (n = 282) and 1-year (n = 143) changes in the levels of fatty acids in blood cell membranes with circulating inflammatory markers in older adults at high cardiovascular risk. The data for this cross-sectional analysis was obtained from a case-control study within the PREDIMED study. Linear regression with elastic net penalty was applied to test associations between measured fatty acids and inflammatory markers. Several fatty acids were associated with interferon-γ (IFNγ) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year. Omega-6 fatty acids were consistently positively associated with pro-inflammatory IL-6 and IL-8 at baseline. Omega-3 fatty acids including C20:5n3 and C18:3n3 were negatively associated with IFN-γ at 1 year. It is interesting to note that the cis and trans forms of C16:1n7 at 1 year were oppositely associated with the inflammatory markers. C16:1n7trans was negatively associated with IFN-γ, IL-6, IL-8, IL-10, and IL-1b, whereas C16:1n7cis was positively associated with IL-1b. This study adds to the growing body of evidence suggesting potential differences in inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. 2021-09-20T09:57:19Z 2021-09-20T09:57:19Z 2019 info:eu-repo/semantics/article https://hdl.handle.net/10171/62035 eng info:eu-repo/grantAgreement/EC/H2020/713679/EU info:eu-repo/semantics/openAccess application/pdf MDPI AG |
| spellingShingle | Materias Investigacion::Ciencias de la Salud::Medicina preventiva Cell membranes Fatty acids Inflammation Muralidharan, J. (Jananee) Papandreou, C. (Christopher) Sala-Vila, A. (Aleix) Rosique-Esteban, N. (Nuria) Fito, M. (Montserrat) Estruch, R. (Ramón) Martinez-Gonzalez, M.A. (Miguel Ángel) Corella, D. (Dolores) Ros, E. (Emilio) Razquin, C. (Cristina) Castañer, O. (Olga) Salas-Salvado, J. (Jordi) Bullo, M. (Monica) Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis |
| title | Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis |
| title_full | Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis |
| title_fullStr | Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis |
| title_full_unstemmed | Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis |
| title_short | Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis |
| title_sort | fatty acids composition of blood cell membranes and peripheral inflammation in the predimed study: a cross-sectional analysis |
| topic | Materias Investigacion::Ciencias de la Salud::Medicina preventiva Cell membranes Fatty acids Inflammation |
| url | https://hdl.handle.net/10171/62035 |
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