Potential therapeutic targets shared between leishmaniasis and cancer
The association of leishmaniasis and malignancies in human and animal models has been highlighted in recent years. The misdiagnosis of coexistence of leishmaniasis and cancer and the use of common drugs in the treatment of such diseases prompt us to further survey the molecular biology of Leishmania...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | info:eu-repo/semantics/article |
| Language: | spa |
| Published: |
Cambridge University Press
2021
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/62083 |
| _version_ | 1793400133254119424 |
|---|---|
| author | Rashidi, S. (Sajad) Fernández-Rubio, C. (Celia) Manzano-Román, R. (Raúl) Mansouri, R. (Reza) Shafiei, R. (Reza) Ali-Hassanzadeh, M. (Mohammad) Barazesh, A. (Afshin) Karimazar, M. (Mohammadreza) Hatam, G. (Gholamreza) Nguewa, P.A. (Paul Alain) |
| author_facet | Rashidi, S. (Sajad) Fernández-Rubio, C. (Celia) Manzano-Román, R. (Raúl) Mansouri, R. (Reza) Shafiei, R. (Reza) Ali-Hassanzadeh, M. (Mohammad) Barazesh, A. (Afshin) Karimazar, M. (Mohammadreza) Hatam, G. (Gholamreza) Nguewa, P.A. (Paul Alain) |
| author_sort | Rashidi, S. (Sajad) |
| collection | DSpace |
| description | The association of leishmaniasis and malignancies in human and animal models has been highlighted in recent years. The misdiagnosis of coexistence of leishmaniasis and cancer and the use of common drugs in the treatment of such diseases prompt us to further survey the molecular biology of Leishmania parasites and cancer cells. The information regarding common expressed proteins, as possible therapeutic targets, in Leishmania parasites and cancer cells is scarce. Therefore, the current study reviews proteins, and investigates the regulation and functions of several key proteins in Leishmania parasites and cancer cells. The up- and down-regulations of such proteins were mostly related to survival, development, pathogenicity, metabolic pathways and vital signalling in Leishmania parasites and cancer cells. The presence of common expressed proteins in Leishmania parasites and cancer cells reveals valuable information regarding the possible shared mechanisms of pathogenicity and opportunities for therapeutic targeting in leishmaniasis and cancers in the future. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-62083 |
| institution | Universidad de Navarra |
| language | spa |
| publishDate | 2021 |
| publisher | Cambridge University Press |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-620832021-09-29T01:07:37Z Potential therapeutic targets shared between leishmaniasis and cancer Rashidi, S. (Sajad) Fernández-Rubio, C. (Celia) Manzano-Román, R. (Raúl) Mansouri, R. (Reza) Shafiei, R. (Reza) Ali-Hassanzadeh, M. (Mohammad) Barazesh, A. (Afshin) Karimazar, M. (Mohammadreza) Hatam, G. (Gholamreza) Nguewa, P.A. (Paul Alain) Cancer Common protein Drug Leishmaniasis Therapeutic target The association of leishmaniasis and malignancies in human and animal models has been highlighted in recent years. The misdiagnosis of coexistence of leishmaniasis and cancer and the use of common drugs in the treatment of such diseases prompt us to further survey the molecular biology of Leishmania parasites and cancer cells. The information regarding common expressed proteins, as possible therapeutic targets, in Leishmania parasites and cancer cells is scarce. Therefore, the current study reviews proteins, and investigates the regulation and functions of several key proteins in Leishmania parasites and cancer cells. The up- and down-regulations of such proteins were mostly related to survival, development, pathogenicity, metabolic pathways and vital signalling in Leishmania parasites and cancer cells. The presence of common expressed proteins in Leishmania parasites and cancer cells reveals valuable information regarding the possible shared mechanisms of pathogenicity and opportunities for therapeutic targeting in leishmaniasis and cancers in the future. 2021-09-28T10:21:12Z 2021-09-28T10:21:12Z 2021 info:eu-repo/semantics/article https://hdl.handle.net/10171/62083 spa info:eu-repo/semantics/openAccess application/pdf Cambridge University Press |
| spellingShingle | Cancer Common protein Drug Leishmaniasis Therapeutic target Rashidi, S. (Sajad) Fernández-Rubio, C. (Celia) Manzano-Román, R. (Raúl) Mansouri, R. (Reza) Shafiei, R. (Reza) Ali-Hassanzadeh, M. (Mohammad) Barazesh, A. (Afshin) Karimazar, M. (Mohammadreza) Hatam, G. (Gholamreza) Nguewa, P.A. (Paul Alain) Potential therapeutic targets shared between leishmaniasis and cancer |
| title | Potential therapeutic targets shared between leishmaniasis and cancer |
| title_full | Potential therapeutic targets shared between leishmaniasis and cancer |
| title_fullStr | Potential therapeutic targets shared between leishmaniasis and cancer |
| title_full_unstemmed | Potential therapeutic targets shared between leishmaniasis and cancer |
| title_short | Potential therapeutic targets shared between leishmaniasis and cancer |
| title_sort | potential therapeutic targets shared between leishmaniasis and cancer |
| topic | Cancer Common protein Drug Leishmaniasis Therapeutic target |
| url | https://hdl.handle.net/10171/62083 |
| work_keys_str_mv | AT rashidissajad potentialtherapeutictargetssharedbetweenleishmaniasisandcancer AT fernandezrubioccelia potentialtherapeutictargetssharedbetweenleishmaniasisandcancer AT manzanoromanrraul potentialtherapeutictargetssharedbetweenleishmaniasisandcancer AT mansourirreza potentialtherapeutictargetssharedbetweenleishmaniasisandcancer AT shafieirreza potentialtherapeutictargetssharedbetweenleishmaniasisandcancer AT alihassanzadehmmohammad potentialtherapeutictargetssharedbetweenleishmaniasisandcancer AT barazeshaafshin potentialtherapeutictargetssharedbetweenleishmaniasisandcancer AT karimazarmmohammadreza potentialtherapeutictargetssharedbetweenleishmaniasisandcancer AT hatamggholamreza potentialtherapeutictargetssharedbetweenleishmaniasisandcancer AT nguewapapaulalain potentialtherapeutictargetssharedbetweenleishmaniasisandcancer |