Optimization of tumor immunotherapy in breast carcinoma. Tumor microvasculature normalization: blood vessels' endothelium
Breast cancer is one of the most common and malignant cancers nowadays. Like many cancers, it is extensively regulated by pro-angiogenic and pro-lymphangiogenic factors, which induce rapid vasculature growth. This results in aberrant vessels which enhance a pro-tumor environment by preventing tre...
| Main Authors: | , |
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| Format: | info:eu-repo/semantics/bachelorThesis |
| Language: | eng |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/62155 |
| _version_ | 1793400284800614400 |
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| author | Fierro-Hernández, P. (Patricia) Rouzaut, A. (Ana) |
| author_facet | Fierro-Hernández, P. (Patricia) Rouzaut, A. (Ana) |
| author_sort | Fierro-Hernández, P. (Patricia) |
| collection | DSpace |
| description | Breast cancer is one of the most common and malignant cancers nowadays. Like many
cancers, it is extensively regulated by pro-angiogenic and pro-lymphangiogenic factors, which
induce rapid vasculature growth. This results in aberrant vessels which enhance a pro-tumor
environment by preventing treatment against cancer to get to the tumor, inducing the
malignancy of cancer cells, and inhibiting the immune response. In the last years, antiangiogenic
treatment was suggested as a possible way to eliminate the tumor-supporting
environment. This approach was soon replaced by the judicious use of these anti-angiogenic
molecules in normalizing concentrations, to prevent pro-tumor effects, such as cell
malignification. In a novel approach to prevent these processes to occur, we have designed a
treatment based on the normalization of the tumoral vasculature of triple-negative breast
carcinoma, so they return to their physiological state. For this aim, we have analyzed the
effects of the blockage of VEGF-A and VEGF-C signaling pathways (angiogenesis and
lymphangiogenesis), by targeting their receptors, VEGFR2 and VEGFR3, with inhibitor
molecules (DC101 antibody and SAR131675 molecules). |
| format | info:eu-repo/semantics/bachelorThesis |
| id | oai:dadun.unav.edu:10171-62155 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2021 |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-621552021-10-07T01:05:35Z Optimization of tumor immunotherapy in breast carcinoma. Tumor microvasculature normalization: blood vessels' endothelium Fierro-Hernández, P. (Patricia) Rouzaut, A. (Ana) Materias Investigacion::Ciencias de la vida::Bioquímica Anti-angiogenesis therapy Blood vessels’ endothelium Breast carcinoma Breast cancer is one of the most common and malignant cancers nowadays. Like many cancers, it is extensively regulated by pro-angiogenic and pro-lymphangiogenic factors, which induce rapid vasculature growth. This results in aberrant vessels which enhance a pro-tumor environment by preventing treatment against cancer to get to the tumor, inducing the malignancy of cancer cells, and inhibiting the immune response. In the last years, antiangiogenic treatment was suggested as a possible way to eliminate the tumor-supporting environment. This approach was soon replaced by the judicious use of these anti-angiogenic molecules in normalizing concentrations, to prevent pro-tumor effects, such as cell malignification. In a novel approach to prevent these processes to occur, we have designed a treatment based on the normalization of the tumoral vasculature of triple-negative breast carcinoma, so they return to their physiological state. For this aim, we have analyzed the effects of the blockage of VEGF-A and VEGF-C signaling pathways (angiogenesis and lymphangiogenesis), by targeting their receptors, VEGFR2 and VEGFR3, with inhibitor molecules (DC101 antibody and SAR131675 molecules). 2021-10-06T10:01:07Z 2021-10-06T10:01:07Z 2021 2021 info:eu-repo/semantics/bachelorThesis https://hdl.handle.net/10171/62155 eng info:eu-repo/semantics/openAccess application/pdf |
| spellingShingle | Materias Investigacion::Ciencias de la vida::Bioquímica Anti-angiogenesis therapy Blood vessels’ endothelium Breast carcinoma Fierro-Hernández, P. (Patricia) Rouzaut, A. (Ana) Optimization of tumor immunotherapy in breast carcinoma. Tumor microvasculature normalization: blood vessels' endothelium |
| title | Optimization of tumor immunotherapy in breast carcinoma. Tumor microvasculature normalization: blood vessels' endothelium |
| title_full | Optimization of tumor immunotherapy in breast carcinoma. Tumor microvasculature normalization: blood vessels' endothelium |
| title_fullStr | Optimization of tumor immunotherapy in breast carcinoma. Tumor microvasculature normalization: blood vessels' endothelium |
| title_full_unstemmed | Optimization of tumor immunotherapy in breast carcinoma. Tumor microvasculature normalization: blood vessels' endothelium |
| title_short | Optimization of tumor immunotherapy in breast carcinoma. Tumor microvasculature normalization: blood vessels' endothelium |
| title_sort | optimization of tumor immunotherapy in breast carcinoma. tumor microvasculature normalization: blood vessels' endothelium |
| topic | Materias Investigacion::Ciencias de la vida::Bioquímica Anti-angiogenesis therapy Blood vessels’ endothelium Breast carcinoma |
| url | https://hdl.handle.net/10171/62155 |
| work_keys_str_mv | AT fierrohernandezppatricia optimizationoftumorimmunotherapyinbreastcarcinomatumormicrovasculaturenormalizationbloodvesselsendothelium AT rouzautaana optimizationoftumorimmunotherapyinbreastcarcinomatumormicrovasculaturenormalizationbloodvesselsendothelium |