Complement in metastasis: a comp in the camp
The complement system represents a pillar of the innate immune response. This system, critical for host defense against pathogens, encompasses more than 50 soluble, and membrane-bound proteins. Emerging evidence underscores its clinical relevance in tumor progression and its role in metastasis, o...
| Main Authors: | , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
Frontiers Media SA
2021
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/62314 |
| _version_ | 1793400158596104192 |
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| author | Ajona, D. (Daniel) Ortiz-Espinosa, S. (Sergio) Pio, R. (Rubén) Lecanda, F. (Fernando) |
| author_facet | Ajona, D. (Daniel) Ortiz-Espinosa, S. (Sergio) Pio, R. (Rubén) Lecanda, F. (Fernando) |
| author_sort | Ajona, D. (Daniel) |
| collection | DSpace |
| description | The complement system represents a pillar of the innate immune response. This system,
critical for host defense against pathogens, encompasses more than 50 soluble, and
membrane-bound proteins. Emerging evidence underscores its clinical relevance in
tumor progression and its role in metastasis, one of the hallmarks of cancer. The multistep
process of metastasis entails the acquisition of advantageous functions required for
the formation of secondary tumors. Thus, targeting components of the complement
system could impact not only on tumor initiation but also on several crucial steps
along tumor dissemination. This novel vulnerability could be concomitantly exploited
with current strategies overcoming tumor-mediated immunosuppression to provide a
substantial clinical benefit in the treatment of metastatic disease. In this review, we
offer a tour d’horizon on recent advances in this area and their prospective potential
for cancer treatment. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-62314 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2021 |
| publisher | Frontiers Media SA |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-623142021-11-05T02:04:48Z Complement in metastasis: a comp in the camp Ajona, D. (Daniel) Ortiz-Espinosa, S. (Sergio) Pio, R. (Rubén) Lecanda, F. (Fernando) Cancer Metastasis Complement Tumor microenvironment Anaphylatoxin Bone colonization The complement system represents a pillar of the innate immune response. This system, critical for host defense against pathogens, encompasses more than 50 soluble, and membrane-bound proteins. Emerging evidence underscores its clinical relevance in tumor progression and its role in metastasis, one of the hallmarks of cancer. The multistep process of metastasis entails the acquisition of advantageous functions required for the formation of secondary tumors. Thus, targeting components of the complement system could impact not only on tumor initiation but also on several crucial steps along tumor dissemination. This novel vulnerability could be concomitantly exploited with current strategies overcoming tumor-mediated immunosuppression to provide a substantial clinical benefit in the treatment of metastatic disease. In this review, we offer a tour d’horizon on recent advances in this area and their prospective potential for cancer treatment. 2021-11-04T08:28:20Z 2021-11-04T08:28:20Z 2019 info:eu-repo/semantics/article https://hdl.handle.net/10171/62314 eng info:eu-repo/semantics/openAccess application/pdf Frontiers Media SA |
| spellingShingle | Cancer Metastasis Complement Tumor microenvironment Anaphylatoxin Bone colonization Ajona, D. (Daniel) Ortiz-Espinosa, S. (Sergio) Pio, R. (Rubén) Lecanda, F. (Fernando) Complement in metastasis: a comp in the camp |
| title | Complement in metastasis: a comp in the camp |
| title_full | Complement in metastasis: a comp in the camp |
| title_fullStr | Complement in metastasis: a comp in the camp |
| title_full_unstemmed | Complement in metastasis: a comp in the camp |
| title_short | Complement in metastasis: a comp in the camp |
| title_sort | complement in metastasis: a comp in the camp |
| topic | Cancer Metastasis Complement Tumor microenvironment Anaphylatoxin Bone colonization |
| url | https://hdl.handle.net/10171/62314 |
| work_keys_str_mv | AT ajonaddaniel complementinmetastasisacompinthecamp AT ortizespinosassergio complementinmetastasisacompinthecamp AT piorruben complementinmetastasisacompinthecamp AT lecandaffernando complementinmetastasisacompinthecamp |