Metabolomics and microbiomes as potential tools to evaluate the effects of the mediterranean diet
The approach to studying diet–health relationships has progressively shifted from individual dietary components to overall dietary patterns that affect the interaction and balance of low-molecular-weight metabolites (metabolome) and host-enteric microbial ecology (microbiome). Even though the Med...
| Main Authors: | , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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MDPI AG
2021
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| Online Access: | https://hdl.handle.net/10171/62377 |
| _version_ | 1793400180103446528 |
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| author | Jin, Q. (Qi) Black, A. (Alicen) Kales, S.N. (Stefanos N.) Vattem, D. (Dhiraj) Ruiz-Canela, M. (Miguel) Sotos-Prieto, M. (Mercedes) |
| author_facet | Jin, Q. (Qi) Black, A. (Alicen) Kales, S.N. (Stefanos N.) Vattem, D. (Dhiraj) Ruiz-Canela, M. (Miguel) Sotos-Prieto, M. (Mercedes) |
| author_sort | Jin, Q. (Qi) |
| collection | DSpace |
| description | The approach to studying diet–health relationships has progressively shifted from
individual dietary components to overall dietary patterns that affect the interaction and balance of
low-molecular-weight metabolites (metabolome) and host-enteric microbial ecology (microbiome).
Even though the Mediterranean diet (MedDiet) has been recognized as a powerful strategy to
improve health, the accurate assessment of exposure to the MedDiet has been a major challenge in
epidemiological and clinical studies. Interestingly, while the effects of individual dietary components
on the metabolome have been described, studies investigating metabolomic profiles in response
to overall dietary patterns (including the MedDiet), although limited, have been gaining attention.
Similarly, the beneficial effects of the MedDiet on cardiometabolic outcomes may be mediated through
gut microbial changes. Accumulating evidence linking food ingestion and enteric microbiome
alterations merits the evaluation of the microbiome-mediated effects of the MedDiet on metabolic
pathways implicated in disease. In this narrative review, we aimed to summarize the current
evidence from observational and clinical trials involving the MedDiet by (1) assessing changes in the
metabolome and microbiome for the measurement of diet pattern adherence and (2) assessing health
outcomes related to the MedDiet through alterations to human metabolomics and/or the microbiome. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-62377 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2021 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-623772021-11-10T02:05:10Z Metabolomics and microbiomes as potential tools to evaluate the effects of the mediterranean diet Jin, Q. (Qi) Black, A. (Alicen) Kales, S.N. (Stefanos N.) Vattem, D. (Dhiraj) Ruiz-Canela, M. (Miguel) Sotos-Prieto, M. (Mercedes) Mediterranean diet Metabolomics Microbiome The approach to studying diet–health relationships has progressively shifted from individual dietary components to overall dietary patterns that affect the interaction and balance of low-molecular-weight metabolites (metabolome) and host-enteric microbial ecology (microbiome). Even though the Mediterranean diet (MedDiet) has been recognized as a powerful strategy to improve health, the accurate assessment of exposure to the MedDiet has been a major challenge in epidemiological and clinical studies. Interestingly, while the effects of individual dietary components on the metabolome have been described, studies investigating metabolomic profiles in response to overall dietary patterns (including the MedDiet), although limited, have been gaining attention. Similarly, the beneficial effects of the MedDiet on cardiometabolic outcomes may be mediated through gut microbial changes. Accumulating evidence linking food ingestion and enteric microbiome alterations merits the evaluation of the microbiome-mediated effects of the MedDiet on metabolic pathways implicated in disease. In this narrative review, we aimed to summarize the current evidence from observational and clinical trials involving the MedDiet by (1) assessing changes in the metabolome and microbiome for the measurement of diet pattern adherence and (2) assessing health outcomes related to the MedDiet through alterations to human metabolomics and/or the microbiome. 2021-11-09T11:10:48Z 2021-11-09T11:10:48Z 2019 info:eu-repo/semantics/article https://hdl.handle.net/10171/62377 eng info:eu-repo/semantics/openAccess application/pdf MDPI AG |
| spellingShingle | Mediterranean diet Metabolomics Microbiome Jin, Q. (Qi) Black, A. (Alicen) Kales, S.N. (Stefanos N.) Vattem, D. (Dhiraj) Ruiz-Canela, M. (Miguel) Sotos-Prieto, M. (Mercedes) Metabolomics and microbiomes as potential tools to evaluate the effects of the mediterranean diet |
| title | Metabolomics and microbiomes as potential tools to evaluate the effects of the mediterranean diet |
| title_full | Metabolomics and microbiomes as potential tools to evaluate the effects of the mediterranean diet |
| title_fullStr | Metabolomics and microbiomes as potential tools to evaluate the effects of the mediterranean diet |
| title_full_unstemmed | Metabolomics and microbiomes as potential tools to evaluate the effects of the mediterranean diet |
| title_short | Metabolomics and microbiomes as potential tools to evaluate the effects of the mediterranean diet |
| title_sort | metabolomics and microbiomes as potential tools to evaluate the effects of the mediterranean diet |
| topic | Mediterranean diet Metabolomics Microbiome |
| url | https://hdl.handle.net/10171/62377 |
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