Association between ideal cardiovascular health and telomere length in participants older than 55 years old from the SUN cohort
Introduction and objectives: Telomeres are noncoding regions located at the end of chromosomes and their shortening has been associated with risk factors and cardiovascular disease. The aim of this study was to evaluate the association between ideal cardiovascular health (Life’s simple 7) and the...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Elsevier
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/63736 |
| _version_ | 1793400134919258112 |
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| author | Alonso-Pedrero, L. (Lucía) Ojeda-Rodríguez, A. (Ana) Zalba, G. (Guillermo) Razquin, C. (Cristina) Martinez-Gonzalez, M.A. (Miguel Ángel) Bes-Rastrollo, M. (Maira) Marti-del-Moral, A. (Amelia) |
| author_facet | Alonso-Pedrero, L. (Lucía) Ojeda-Rodríguez, A. (Ana) Zalba, G. (Guillermo) Razquin, C. (Cristina) Martinez-Gonzalez, M.A. (Miguel Ángel) Bes-Rastrollo, M. (Maira) Marti-del-Moral, A. (Amelia) |
| author_sort | Alonso-Pedrero, L. (Lucía) |
| collection | DSpace |
| description | Introduction and objectives: Telomeres are noncoding regions located at the end of chromosomes and
their shortening has been associated with risk factors and cardiovascular disease. The aim of this study
was to evaluate the association between ideal cardiovascular health (Life’s simple 7) and the odds of
having short telomeres in a subsample of participants older than 55 years from the Seguimiento
Universidad de Navarra (SUN) study.
Methods: We included 886 participants older than 55 years (645 men and 241 women). Telomere length
was measured using a real-time quantitative polymerase chain reaction. Cardiovascular health score
was defined by the American Heart Association as a composite score of 7 key risk factors (smoking status,
physical activity, diet, body mass index, blood pressure, total cholesterol, and fasting blood glucose) with
0 to 2 points for each factor. We categorized this score in tertiles as poor (0-9 points), intermediate (10-
11 points) and ideal (12-14 points). The odds of having short telomeres was defined as telomere length
below the 20th percentile.
Results: Individuals with higher ideal cardiovascular health had a lower prevalence of having short
telomeres (adjusted OR, 0.60; 95%CI, 0.34-1.05; P trend = .052). This association was statistically
significant in men (adjusted OR, 0.37; 95%CI, 0.17-0.83; P trend = .025) but not in women.
Conclusions: An inverse association between cardiovascular health score and short telomeres was found
especially for men older than 55 years in the SUN population. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-63736 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-637362024-01-24T08:58:37Z Association between ideal cardiovascular health and telomere length in participants older than 55 years old from the SUN cohort Alonso-Pedrero, L. (Lucía) Ojeda-Rodríguez, A. (Ana) Zalba, G. (Guillermo) Razquin, C. (Cristina) Martinez-Gonzalez, M.A. (Miguel Ángel) Bes-Rastrollo, M. (Maira) Marti-del-Moral, A. (Amelia) SUN study Cardiovascular health score Cardiovascular risk Telomere length Cross-sectional study Cohorte SUN Índice de Salud Cardiovascular Riesgo cardiovascular Longitud telomérica Estudio transversal Introduction and objectives: Telomeres are noncoding regions located at the end of chromosomes and their shortening has been associated with risk factors and cardiovascular disease. The aim of this study was to evaluate the association between ideal cardiovascular health (Life’s simple 7) and the odds of having short telomeres in a subsample of participants older than 55 years from the Seguimiento Universidad de Navarra (SUN) study. Methods: We included 886 participants older than 55 years (645 men and 241 women). Telomere length was measured using a real-time quantitative polymerase chain reaction. Cardiovascular health score was defined by the American Heart Association as a composite score of 7 key risk factors (smoking status, physical activity, diet, body mass index, blood pressure, total cholesterol, and fasting blood glucose) with 0 to 2 points for each factor. We categorized this score in tertiles as poor (0-9 points), intermediate (10- 11 points) and ideal (12-14 points). The odds of having short telomeres was defined as telomere length below the 20th percentile. Results: Individuals with higher ideal cardiovascular health had a lower prevalence of having short telomeres (adjusted OR, 0.60; 95%CI, 0.34-1.05; P trend = .052). This association was statistically significant in men (adjusted OR, 0.37; 95%CI, 0.17-0.83; P trend = .025) but not in women. Conclusions: An inverse association between cardiovascular health score and short telomeres was found especially for men older than 55 years in the SUN population. Introducción y objetivos: Los telómeros son regiones no codificantes localizadas al final de los cromosomas de células eucariotas, y su acortamiento se ha visto relacionado con la enfermedad cardiovascular y sus factores de riesgo. El objetivo de este estudio es evaluar la asociación entre el índice de salud cardiovascular ideal y el riesgo de telómero corto en una población de sujetos de edad avanzada de la cohorte Seguimiento Universidad de Navarra (SUN). Métodos: Se valoró a 886 adultos mayores de 55 años (645 varones y 241 mujeres). La longitud telomérica se midió utilizando qPCR (quantitative protein chain reaction) en tiempo real y reacción única. El índice de salud cardiovascular «Life’s simple 7» se definió según la American Heart Association mediante la puntuación de 7 ítems con valores de 0 a 2 para cada uno: tabaquismo, actividad física, dieta, índice de masa corporal, presión arterial, colesterol total y glucosa en sangre. La máxima puntuación del índice corresponde a 14 puntos. Se categorizó en terciles: pobre (0-9 puntos), intermedio (10-11 puntos) e ideal (12-14 puntos). El riesgo de telómero corto se definió como una longitud telomérica por debajo del percentil 20. Resultados: Sujetos con altos valores en el índice de salud cardiovascular ideal tenían menos riesgo de telómero corto (OR ajustada = 0,60; IC95%, 0,34-1,05; p de tendencia lineal = 0,052). Esta asociación fue significativa en varones (OR ajustada = 0,37; IC95%, 0,17-0,83; p de tendencia lineal = 0,025), pero no en mujeres. Conclusiones: En varones mayores de 55 años, existe una asociación inversa entre el índice de salud cardiovascular y el riesgo de tener telómeros cortos. 2022-06-29T10:28:26Z 2022-06-29T10:28:26Z 2022 info:eu-repo/semantics/article https://hdl.handle.net/10171/63736 eng info:eu-repo/semantics/openAccess application/pdf Elsevier |
| spellingShingle | SUN study Cardiovascular health score Cardiovascular risk Telomere length Cross-sectional study Cohorte SUN Índice de Salud Cardiovascular Riesgo cardiovascular Longitud telomérica Estudio transversal Alonso-Pedrero, L. (Lucía) Ojeda-Rodríguez, A. (Ana) Zalba, G. (Guillermo) Razquin, C. (Cristina) Martinez-Gonzalez, M.A. (Miguel Ángel) Bes-Rastrollo, M. (Maira) Marti-del-Moral, A. (Amelia) Association between ideal cardiovascular health and telomere length in participants older than 55 years old from the SUN cohort |
| title | Association between ideal cardiovascular health and telomere length in participants older than 55 years old from the SUN cohort |
| title_full | Association between ideal cardiovascular health and telomere length in participants older than 55 years old from the SUN cohort |
| title_fullStr | Association between ideal cardiovascular health and telomere length in participants older than 55 years old from the SUN cohort |
| title_full_unstemmed | Association between ideal cardiovascular health and telomere length in participants older than 55 years old from the SUN cohort |
| title_short | Association between ideal cardiovascular health and telomere length in participants older than 55 years old from the SUN cohort |
| title_sort | association between ideal cardiovascular health and telomere length in participants older than 55 years old from the sun cohort |
| topic | SUN study Cardiovascular health score Cardiovascular risk Telomere length Cross-sectional study Cohorte SUN Índice de Salud Cardiovascular Riesgo cardiovascular Longitud telomérica Estudio transversal |
| url | https://hdl.handle.net/10171/63736 |
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