miRNAs in the regulation of mTOR signaling and host immune responses: the case of Leishmania infections
Micro RNAs (miRNAs), as regulators of gene expression at the post-transcriptional level, can respond to/or interact with cell signaling and affect the pathogenesis of different diseases/infections. The interaction/crosstalk of miRNAs with various cellular signaling networks including mTOR (as a mast...
| Main Authors: | , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
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2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/63901 |
| _version_ | 1793400115540525056 |
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| author | Rashidi, S. (Sajad) Mansouri, R. (Reza) Ali-Hassanzadeh, M. (Mohammad) Ghani, E. (Esmaeel) Karimazar, M. (Mohammadreza) Muro, A. (Antonio) Nguewa, P.A. (Paul Alain) Manzano-Román, R. (Raúl) |
| author_facet | Rashidi, S. (Sajad) Mansouri, R. (Reza) Ali-Hassanzadeh, M. (Mohammad) Ghani, E. (Esmaeel) Karimazar, M. (Mohammadreza) Muro, A. (Antonio) Nguewa, P.A. (Paul Alain) Manzano-Román, R. (Raúl) |
| author_sort | Rashidi, S. (Sajad) |
| collection | DSpace |
| description | Micro RNAs (miRNAs), as regulators of gene expression at the post-transcriptional level, can respond to/or interact with cell signaling and affect the pathogenesis of different diseases/infections. The interaction/crosstalk of miRNAs with various cellular signaling networks including mTOR (as a master regulator of signaling relevant to different cellular mechanisms) might lead to the initiation, progression or restriction of certain disease processes. There are numerous studies that have identified the crosstalk between regulatory miRNA expression and the mTOR pathway (or mTOR signaling regulated by miRNAs) in different diseases which has a dual function in pathogenesis. However, the corresponding information in parasitic infections remains scarce. miRNAs have been suggested as specific targets for therapeutic strategies in several disorders such as parasitic infections. Thus, the targeting of miRNAs (as the modulators/regulators of mTOR) by small molecules and RNA-based therapeutics and consequently managing and modulating mTOR signaling and the downstream/related cell signaling/pathways might shed some light on the design of new therapeutic strategies against parasitic diseases, including Leishmaniasis. Accordingly, the present study attempts to highlight the importance of the crosstalk between regulatory miRNAs and mTOR signaling, and to review the relevant insights into parasitic infections by focusing specifically on Leishmania. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-63901 |
| institution | Universidad de Navarra |
| language | English |
| publishDate | 2022 |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-639012022-08-25T01:04:08Z miRNAs in the regulation of mTOR signaling and host immune responses: the case of Leishmania infections Rashidi, S. (Sajad) Mansouri, R. (Reza) Ali-Hassanzadeh, M. (Mohammad) Ghani, E. (Esmaeel) Karimazar, M. (Mohammadreza) Muro, A. (Antonio) Nguewa, P.A. (Paul Alain) Manzano-Román, R. (Raúl) miRNAs mTOR signaling Crosstalk Parasites Leishmania Micro RNAs (miRNAs), as regulators of gene expression at the post-transcriptional level, can respond to/or interact with cell signaling and affect the pathogenesis of different diseases/infections. The interaction/crosstalk of miRNAs with various cellular signaling networks including mTOR (as a master regulator of signaling relevant to different cellular mechanisms) might lead to the initiation, progression or restriction of certain disease processes. There are numerous studies that have identified the crosstalk between regulatory miRNA expression and the mTOR pathway (or mTOR signaling regulated by miRNAs) in different diseases which has a dual function in pathogenesis. However, the corresponding information in parasitic infections remains scarce. miRNAs have been suggested as specific targets for therapeutic strategies in several disorders such as parasitic infections. Thus, the targeting of miRNAs (as the modulators/regulators of mTOR) by small molecules and RNA-based therapeutics and consequently managing and modulating mTOR signaling and the downstream/related cell signaling/pathways might shed some light on the design of new therapeutic strategies against parasitic diseases, including Leishmaniasis. Accordingly, the present study attempts to highlight the importance of the crosstalk between regulatory miRNAs and mTOR signaling, and to review the relevant insights into parasitic infections by focusing specifically on Leishmania. 2022-08-11T09:41:42Z 2022-08-11T09:41:42Z 2022 info:eu-repo/semantics/article https://hdl.handle.net/10171/63901 en https://pubmed.ncbi.nlm.nih.gov/35367408/ info:eu-repo/semantics/openAccess application/pdf |
| spellingShingle | miRNAs mTOR signaling Crosstalk Parasites Leishmania Rashidi, S. (Sajad) Mansouri, R. (Reza) Ali-Hassanzadeh, M. (Mohammad) Ghani, E. (Esmaeel) Karimazar, M. (Mohammadreza) Muro, A. (Antonio) Nguewa, P.A. (Paul Alain) Manzano-Román, R. (Raúl) miRNAs in the regulation of mTOR signaling and host immune responses: the case of Leishmania infections |
| title | miRNAs in the regulation of mTOR signaling and host immune responses: the case of Leishmania infections |
| title_full | miRNAs in the regulation of mTOR signaling and host immune responses: the case of Leishmania infections |
| title_fullStr | miRNAs in the regulation of mTOR signaling and host immune responses: the case of Leishmania infections |
| title_full_unstemmed | miRNAs in the regulation of mTOR signaling and host immune responses: the case of Leishmania infections |
| title_short | miRNAs in the regulation of mTOR signaling and host immune responses: the case of Leishmania infections |
| title_sort | mirnas in the regulation of mtor signaling and host immune responses: the case of leishmania infections |
| topic | miRNAs mTOR signaling Crosstalk Parasites Leishmania |
| url | https://hdl.handle.net/10171/63901 |
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