Predictive value of hyperglycosylated human chorionic gonadotropin for pregnancy outcomes in threatened abortion in first-trimester viable pregnancies
Background. To investigate the value of a single determination of hyperglycosylated hCG (hCG-H) for predicting the clinical outcome of patients with threatened abortion in the first trimester of pregnancy. Methods. Prospective study performed on 86 consecutively selected women with a diagnosis of t...
| Main Authors: | , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Gobierno de Navarra
2022
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| Online Access: | https://hdl.handle.net/10171/64423 |
| _version_ | 1793399932226371584 |
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| author | Salas, A. (Anna) Gastón-Moreno, B. (Begoña) Barrenetxea, J. (J.) Sendino, T. (T.) Jurado, M. (Matías) Alcazar, J.L. (Juan Luis) |
| author_facet | Salas, A. (Anna) Gastón-Moreno, B. (Begoña) Barrenetxea, J. (J.) Sendino, T. (T.) Jurado, M. (Matías) Alcazar, J.L. (Juan Luis) |
| author_sort | Salas, A. (Anna) |
| collection | DSpace |
| description | Background. To investigate the value of a single determination of hyperglycosylated hCG (hCG-H) for predicting the clinical outcome of patients with threatened abortion in the first trimester of pregnancy.
Methods. Prospective study performed on 86 consecutively selected women with a diagnosis of threatened abortion
and viable intrauterine pregnancy in the first trimester of pregnancy, conducted in two tertiary care hospitals. All patients underwent a single blood sample to determine hCG-H and total hCG serum levels and a transvaginal ultrasound 12-24 hours after diagnosis. Patients were monitored to determine whether the outcome was a miscarriage before the 20th week of pregnancy.
Results. Forty-three women (50%) had a miscarriage during the follow-up. We observed a very high correlation between hCG-H and total hCG (r=0.91, p<0.001). Median hCG-H and total hCG from pregnancies with normal outcome was significantly higher than those ending in abortion. hCG-H and total hCG were very similar predictors of pregnancy outcomes (AUC: 0.90 and 0.89, respectively). The ratio hCG-H / total hCG was a poor predictor (AUC:0.64).
Conclusion. A single hCG-H assay is helpful for predicting pregnancy outcomes in women with first trimester
threatened abortion and viable or potentially viable pregnancy at the time of presentation. However, hCG-H is not
a better predictor than total hCG. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-64423 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2022 |
| publisher | Gobierno de Navarra |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-644232023-02-02T10:16:53Z Predictive value of hyperglycosylated human chorionic gonadotropin for pregnancy outcomes in threatened abortion in first-trimester viable pregnancies Salas, A. (Anna) Gastón-Moreno, B. (Begoña) Barrenetxea, J. (J.) Sendino, T. (T.) Jurado, M. (Matías) Alcazar, J.L. (Juan Luis) hCG Early pregnancy First trimester bleeding Threatened abortion Miscarriage Gestación precoz Sangrado en el primer trimestre Amenaza de aborto Aborto espontáneo Background. To investigate the value of a single determination of hyperglycosylated hCG (hCG-H) for predicting the clinical outcome of patients with threatened abortion in the first trimester of pregnancy. Methods. Prospective study performed on 86 consecutively selected women with a diagnosis of threatened abortion and viable intrauterine pregnancy in the first trimester of pregnancy, conducted in two tertiary care hospitals. All patients underwent a single blood sample to determine hCG-H and total hCG serum levels and a transvaginal ultrasound 12-24 hours after diagnosis. Patients were monitored to determine whether the outcome was a miscarriage before the 20th week of pregnancy. Results. Forty-three women (50%) had a miscarriage during the follow-up. We observed a very high correlation between hCG-H and total hCG (r=0.91, p<0.001). Median hCG-H and total hCG from pregnancies with normal outcome was significantly higher than those ending in abortion. hCG-H and total hCG were very similar predictors of pregnancy outcomes (AUC: 0.90 and 0.89, respectively). The ratio hCG-H / total hCG was a poor predictor (AUC:0.64). Conclusion. A single hCG-H assay is helpful for predicting pregnancy outcomes in women with first trimester threatened abortion and viable or potentially viable pregnancy at the time of presentation. However, hCG-H is not a better predictor than total hCG. Fundamento. Investigar el valor de una única determinación de hCG hiperglicosilada (hCG-H) para predecir el resultado clínico de pacientes con amenaza de aborto en el primer trimestre del embarazo. Métodos. Estudio prospectivo realizado en 86 mujeres, seleccionadas consecutivamente, con diagnóstico de amenaza de aborto y embarazo intrauterino viable en el primer trimestre de embarazo, realizado en dos hospitales de tercer nivel. A todas las pacientes se les realizó una única extracción sanguínea para determinar los niveles séricos de hCG-H y hCG total, y una ecografía transvaginal 12-24 horas después del episodio de sangrado. Se realizó seguimiento de las pacientes para determinar si el resultado fue un aborto espontáneo antes de la semana 20 de embarazo. Resultados. Cuarenta y tres mujeres (50%) sufrieron un aborto espontáneo durante el seguimiento. Se observó una correlación muy alta entre hCG-H y hCG total (r=0,91,p<0,001). La mediana de hCG-H y hCG total de los embarazos con resultado normal fue significativamente mayor que la de aquellos que terminaron en aborto. La hCG-H y la hCG total fueron predictores muy similares del resultado del embarazo (AUC: 0,90 y 0,89, respectivamente). La relación hCG-H / hCG total fue un mal predictor (AUC:0,64). Conclusión. La determinación única de hCG-H es útil para predecir el resultado del embarazo en mujeres con amenaza de aborto en el primer trimestre y embarazo viable en el momento de la presentación clínica. Sin embargo, la hCG-H no es mejor predictor que la hCG total. 2022-10-11T07:17:20Z 2022-10-11T07:17:20Z 2021 info:eu-repo/semantics/article https://hdl.handle.net/10171/64423 eng info:eu-repo/semantics/openAccess application/pdf Gobierno de Navarra |
| spellingShingle | hCG Early pregnancy First trimester bleeding Threatened abortion Miscarriage Gestación precoz Sangrado en el primer trimestre Amenaza de aborto Aborto espontáneo Salas, A. (Anna) Gastón-Moreno, B. (Begoña) Barrenetxea, J. (J.) Sendino, T. (T.) Jurado, M. (Matías) Alcazar, J.L. (Juan Luis) Predictive value of hyperglycosylated human chorionic gonadotropin for pregnancy outcomes in threatened abortion in first-trimester viable pregnancies |
| title | Predictive value of hyperglycosylated human chorionic gonadotropin for pregnancy outcomes in threatened abortion in first-trimester viable pregnancies |
| title_full | Predictive value of hyperglycosylated human chorionic gonadotropin for pregnancy outcomes in threatened abortion in first-trimester viable pregnancies |
| title_fullStr | Predictive value of hyperglycosylated human chorionic gonadotropin for pregnancy outcomes in threatened abortion in first-trimester viable pregnancies |
| title_full_unstemmed | Predictive value of hyperglycosylated human chorionic gonadotropin for pregnancy outcomes in threatened abortion in first-trimester viable pregnancies |
| title_short | Predictive value of hyperglycosylated human chorionic gonadotropin for pregnancy outcomes in threatened abortion in first-trimester viable pregnancies |
| title_sort | predictive value of hyperglycosylated human chorionic gonadotropin for pregnancy outcomes in threatened abortion in first-trimester viable pregnancies |
| topic | hCG Early pregnancy First trimester bleeding Threatened abortion Miscarriage Gestación precoz Sangrado en el primer trimestre Amenaza de aborto Aborto espontáneo |
| url | https://hdl.handle.net/10171/64423 |
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