Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality?
The aim of this study was to assess the association between alcohol intake and premature mortality (younger than 65 years) and to explore the effect of potential alcohol underreporting by heavy drinkers. We followed-up 20 272 university graduates. Four categories of alcohol intake were considered (a...
| Main Authors: | , , , , |
|---|---|
| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
Cambridge University Press
2022
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/64588 |
| _version_ | 1793400021548269568 |
|---|---|
| author | Martinez-Gonzalez, M.A. (Miguel Ángel) Barbería-Latasa, M. (María) Pérez-de-Rojas, J. (Javier) Domínguez-Rodriguez, L.J. (Ligia Juliana) Gea, A. (Alfredo) |
| author_facet | Martinez-Gonzalez, M.A. (Miguel Ángel) Barbería-Latasa, M. (María) Pérez-de-Rojas, J. (Javier) Domínguez-Rodriguez, L.J. (Ligia Juliana) Gea, A. (Alfredo) |
| author_sort | Martinez-Gonzalez, M.A. (Miguel Ángel) |
| collection | DSpace |
| description | The aim of this study was to assess the association between alcohol intake and premature mortality (younger than 65 years) and to explore the effect of potential alcohol underreporting by heavy drinkers. We followed-up 20 272 university graduates. Four categories of alcohol intake were considered (abstainer, light, moderate and heavy consumption). Repeated measurements of alcohol intake and updated information on confounders were used in time-dependent Cox models. Potential underreporting of alcohol intake by some heavy drinkers (likely misclassified as light or moderate drinkers) was explicitly addressed in an attempt to correct potential underreporting by using indirect information. During 12·3 years of median follow-up (interquartile range: 6·8–15·0), 226 participants died before their 65th birthday. A higher risk of early mortality was found for the highest category of alcohol intake (≥50 g/d) in comparison with abstention (multivariable-adjusted hazard ratio (HR) = 2·82, 95 % CI 1·38, 5·79). In analyses of alcohol as a continuous variable, the multivariable-adjusted HR was 1·17 (95 % CI 1·08, 1·26), for each 10 g/d of alcohol. This harmful linear association was present both in uncorrected models and in models corrected for potential underreporting. No significant inverse association between light or moderate alcohol intake and premature mortality was observed, even after correcting for potential misclassification. Alcohol intake exhibited a harmful linear dose–response association with premature mortality (<65 years) in this young and highly educated Mediterranean cohort. Our attempts to correct for potential misclassification did not substantially change these results. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-64588 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2022 |
| publisher | Cambridge University Press |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-645882023-07-04T07:16:53Z Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality? Martinez-Gonzalez, M.A. (Miguel Ángel) Barbería-Latasa, M. (María) Pérez-de-Rojas, J. (Javier) Domínguez-Rodriguez, L.J. (Ligia Juliana) Gea, A. (Alfredo) Underreporting Misclassification bias Alcohol FFQ Mortality Prospective studies The aim of this study was to assess the association between alcohol intake and premature mortality (younger than 65 years) and to explore the effect of potential alcohol underreporting by heavy drinkers. We followed-up 20 272 university graduates. Four categories of alcohol intake were considered (abstainer, light, moderate and heavy consumption). Repeated measurements of alcohol intake and updated information on confounders were used in time-dependent Cox models. Potential underreporting of alcohol intake by some heavy drinkers (likely misclassified as light or moderate drinkers) was explicitly addressed in an attempt to correct potential underreporting by using indirect information. During 12·3 years of median follow-up (interquartile range: 6·8–15·0), 226 participants died before their 65th birthday. A higher risk of early mortality was found for the highest category of alcohol intake (≥50 g/d) in comparison with abstention (multivariable-adjusted hazard ratio (HR) = 2·82, 95 % CI 1·38, 5·79). In analyses of alcohol as a continuous variable, the multivariable-adjusted HR was 1·17 (95 % CI 1·08, 1·26), for each 10 g/d of alcohol. This harmful linear association was present both in uncorrected models and in models corrected for potential underreporting. No significant inverse association between light or moderate alcohol intake and premature mortality was observed, even after correcting for potential misclassification. Alcohol intake exhibited a harmful linear dose–response association with premature mortality (<65 years) in this young and highly educated Mediterranean cohort. Our attempts to correct for potential misclassification did not substantially change these results. 2022-11-04T09:23:43Z 2022-11-04T09:23:43Z 2022 info:eu-repo/semantics/article https://hdl.handle.net/10171/64588 eng info:eu-repo/semantics/openAccess application/pdf Cambridge University Press |
| spellingShingle | Underreporting Misclassification bias Alcohol FFQ Mortality Prospective studies Martinez-Gonzalez, M.A. (Miguel Ángel) Barbería-Latasa, M. (María) Pérez-de-Rojas, J. (Javier) Domínguez-Rodriguez, L.J. (Ligia Juliana) Gea, A. (Alfredo) Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality? |
| title | Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality? |
| title_full | Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality? |
| title_fullStr | Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality? |
| title_full_unstemmed | Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality? |
| title_short | Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality? |
| title_sort | alcohol and early mortality (before 65 years) in the ‘seguimiento universidad de navarra’ (sun) cohort: does any level reduce mortality? |
| topic | Underreporting Misclassification bias Alcohol FFQ Mortality Prospective studies |
| url | https://hdl.handle.net/10171/64588 |
| work_keys_str_mv | AT martinezgonzalezmamiguelangel alcoholandearlymortalitybefore65yearsintheseguimientouniversidaddenavarrasuncohortdoesanylevelreducemortality AT barberialatasammaria alcoholandearlymortalitybefore65yearsintheseguimientouniversidaddenavarrasuncohortdoesanylevelreducemortality AT perezderojasjjavier alcoholandearlymortalitybefore65yearsintheseguimientouniversidaddenavarrasuncohortdoesanylevelreducemortality AT dominguezrodriguezljligiajuliana alcoholandearlymortalitybefore65yearsintheseguimientouniversidaddenavarrasuncohortdoesanylevelreducemortality AT geaaalfredo alcoholandearlymortalitybefore65yearsintheseguimientouniversidaddenavarrasuncohortdoesanylevelreducemortality |