Application of single cell transcriptomics to characterize the progression of hematopoietic cells to myeloid malignancies
Hematopoiesis is the process by which blood cells are formed. It has been a broadly studied system since the second half of the 20th century. Attention was drawn to this process after the discovery, in 1951, of the protective role that bone marrow intravenous infusion had against radiation. In th...
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| Format: | info:eu-repo/semantics/doctoralThesis |
| Language: | eng |
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Universidad de Navarra
2023
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| Online Access: | https://hdl.handle.net/10171/65224 |
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| author | Ainciburu-Fernández, M. (Marina) Smerdou, C. (Cristian) Vanrell, L. (Lucía) |
| author_facet | Ainciburu-Fernández, M. (Marina) Smerdou, C. (Cristian) Vanrell, L. (Lucía) |
| author_sort | Ainciburu-Fernández, M. (Marina) |
| collection | DSpace |
| description | Hematopoiesis is the process by which blood cells are formed. It has been a broadly
studied system since the second half of the 20th century. Attention was drawn to this
process after the discovery, in 1951, of the protective role that bone marrow intravenous
infusion had against radiation. In the mid-1950s, it was subsequently discovered that
this protection was caused by transplanted stem cells contained in the bone marrow.
Multipotency of the hematopoietic stem cells (HSCs) was further proven during the 1960s,
with the development of clonal in vivo repopulation assays. Following clonal in vitro
assays, together with the study of cell surface markers and flow sorting, have configured
the current view of the hematopoietic system, as a tree-like hierarchy with the HSCs at the
top and mature cells at the bottom (Figure 1.1) [1, 2].
Hematopoiesis is active throughout life and it maintains the pool of mature blood cells,
which constitute one of the human tissues with highest turnover. Broadly speaking,
specialized blood cells can carry out four main functions: 1) The innate immune system,
composed, among others, by macrophages, dendritic cells and granulocytes, constitutes
the first defense against infection 2) The adaptive immune system, composed by B and T
lymphocytes, carries out a delayed and specialized response against pathogens. 3) Red
blood cells transport oxygen to every cell 4) Platelets take care of wound healing. |
| format | info:eu-repo/semantics/doctoralThesis |
| id | oai:dadun.unav.edu:10171-65224 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2023 |
| publisher | Universidad de Navarra |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-652242023-02-06T06:05:14Z Application of single cell transcriptomics to characterize the progression of hematopoietic cells to myeloid malignancies Ainciburu-Fernández, M. (Marina) Smerdou, C. (Cristian) Vanrell, L. (Lucía) Materias Investigacion::Ciencias de la vida Single cell transcriptomics Hematopoietic cells Myeloid malignancies Hematology Hematopoiesis is the process by which blood cells are formed. It has been a broadly studied system since the second half of the 20th century. Attention was drawn to this process after the discovery, in 1951, of the protective role that bone marrow intravenous infusion had against radiation. In the mid-1950s, it was subsequently discovered that this protection was caused by transplanted stem cells contained in the bone marrow. Multipotency of the hematopoietic stem cells (HSCs) was further proven during the 1960s, with the development of clonal in vivo repopulation assays. Following clonal in vitro assays, together with the study of cell surface markers and flow sorting, have configured the current view of the hematopoietic system, as a tree-like hierarchy with the HSCs at the top and mature cells at the bottom (Figure 1.1) [1, 2]. Hematopoiesis is active throughout life and it maintains the pool of mature blood cells, which constitute one of the human tissues with highest turnover. Broadly speaking, specialized blood cells can carry out four main functions: 1) The innate immune system, composed, among others, by macrophages, dendritic cells and granulocytes, constitutes the first defense against infection 2) The adaptive immune system, composed by B and T lymphocytes, carries out a delayed and specialized response against pathogens. 3) Red blood cells transport oxygen to every cell 4) Platelets take care of wound healing. 2023-01-31T11:44:01Z 2023-01-31T11:44:01Z 2023-01-31 2022-11-30 info:eu-repo/semantics/doctoralThesis https://hdl.handle.net/10171/65224 eng info:eu-repo/semantics/openAccess application/pdf Universidad de Navarra |
| spellingShingle | Materias Investigacion::Ciencias de la vida Single cell transcriptomics Hematopoietic cells Myeloid malignancies Hematology Ainciburu-Fernández, M. (Marina) Smerdou, C. (Cristian) Vanrell, L. (Lucía) Application of single cell transcriptomics to characterize the progression of hematopoietic cells to myeloid malignancies |
| title | Application of single cell transcriptomics to characterize the progression of hematopoietic cells to myeloid malignancies |
| title_full | Application of single cell transcriptomics to characterize the progression of hematopoietic cells to myeloid malignancies |
| title_fullStr | Application of single cell transcriptomics to characterize the progression of hematopoietic cells to myeloid malignancies |
| title_full_unstemmed | Application of single cell transcriptomics to characterize the progression of hematopoietic cells to myeloid malignancies |
| title_short | Application of single cell transcriptomics to characterize the progression of hematopoietic cells to myeloid malignancies |
| title_sort | application of single cell transcriptomics to characterize the progression of hematopoietic cells to myeloid malignancies |
| topic | Materias Investigacion::Ciencias de la vida Single cell transcriptomics Hematopoietic cells Myeloid malignancies Hematology |
| url | https://hdl.handle.net/10171/65224 |
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