ACE-Vitamin Index and Risk of Glaucoma: the SUN Project
Background: Previous studies regarding antioxidant consumption and glaucoma have shown contradictory results. The aim of this study was to analyze the combined effect of the consumption of three vitamins (A, C and E) on the incidence of glaucoma in the SUN Project. Methods: For this study, 18,669 pa...
| Main Authors: | , , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
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2023
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| Online Access: | https://hdl.handle.net/10171/65285 |
| _version_ | 1793400045534445568 |
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| author | Moreno-Montañes, J. (Javier) Gándara-Rodríguez-de-Campoamor, E. (Elsa) Moreno-Galarraga, L. (Laura) Hershey-de-la-Cruz, M.S. (María Soledad) López-Gil, J.F. (José Francisco) Kales, S.N. (Stefanos N.) Bes-Rastrollo, M. (Maira) Martinez-Gonzalez, M.A. (Miguel Ángel) Fernandez-Montero, A. (Alejandro) |
| author_facet | Moreno-Montañes, J. (Javier) Gándara-Rodríguez-de-Campoamor, E. (Elsa) Moreno-Galarraga, L. (Laura) Hershey-de-la-Cruz, M.S. (María Soledad) López-Gil, J.F. (José Francisco) Kales, S.N. (Stefanos N.) Bes-Rastrollo, M. (Maira) Martinez-Gonzalez, M.A. (Miguel Ángel) Fernandez-Montero, A. (Alejandro) |
| author_sort | Moreno-Montañes, J. (Javier) |
| collection | DSpace |
| description | Background: Previous studies regarding antioxidant consumption and glaucoma have shown contradictory results. The aim of this study was to analyze the combined effect of the consumption of three vitamins (A, C and E) on the incidence of glaucoma in the SUN Project. Methods: For this study, 18,669 participants were included. The mean follow-up was 11.5 years. An index including vitamins A, C and E (ACE-Vitamin Index) was calculated. Vitamin intake was extracted from participants' dietary data and vitamin supplements, if taken. Information on glaucoma incidence was collected by previously validated self-reported questionnaires. The association between glaucoma and vitamin intake was assessed by repeated-measures Cox regression using multi-adjusted hazard ratios. Results: A total of 251 (1.3%) cases of glaucoma were detected. Participants with a higher ACE-Vitamin Index presented a reduced risk of glaucoma compared to participants with lower consumption (adjusted HR = 0.73; 95% CI, (0.55-0.98)). When each vitamin was analyzed individually, none of them had a significant protective effect. The protective effect of the ACE-Vitamin Index was higher in men and older participants (>= 55 year). Conclusions: The consumption of vitamins A, C and E considered separately do not seem to exert a protective effect against glaucoma, but when these vitamins are considered together, they are associated with a lower risk of glaucoma. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-65285 |
| institution | Universidad de Navarra |
| language | English |
| publishDate | 2023 |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-652852023-05-03T12:48:23Z ACE-Vitamin Index and Risk of Glaucoma: the SUN Project Moreno-Montañes, J. (Javier) Gándara-Rodríguez-de-Campoamor, E. (Elsa) Moreno-Galarraga, L. (Laura) Hershey-de-la-Cruz, M.S. (María Soledad) López-Gil, J.F. (José Francisco) Kales, S.N. (Stefanos N.) Bes-Rastrollo, M. (Maira) Martinez-Gonzalez, M.A. (Miguel Ángel) Fernandez-Montero, A. (Alejandro) Vitamin A Vitamin C Vitamin E Glaucoma SUN project Background: Previous studies regarding antioxidant consumption and glaucoma have shown contradictory results. The aim of this study was to analyze the combined effect of the consumption of three vitamins (A, C and E) on the incidence of glaucoma in the SUN Project. Methods: For this study, 18,669 participants were included. The mean follow-up was 11.5 years. An index including vitamins A, C and E (ACE-Vitamin Index) was calculated. Vitamin intake was extracted from participants' dietary data and vitamin supplements, if taken. Information on glaucoma incidence was collected by previously validated self-reported questionnaires. The association between glaucoma and vitamin intake was assessed by repeated-measures Cox regression using multi-adjusted hazard ratios. Results: A total of 251 (1.3%) cases of glaucoma were detected. Participants with a higher ACE-Vitamin Index presented a reduced risk of glaucoma compared to participants with lower consumption (adjusted HR = 0.73; 95% CI, (0.55-0.98)). When each vitamin was analyzed individually, none of them had a significant protective effect. The protective effect of the ACE-Vitamin Index was higher in men and older participants (>= 55 year). Conclusions: The consumption of vitamins A, C and E considered separately do not seem to exert a protective effect against glaucoma, but when these vitamins are considered together, they are associated with a lower risk of glaucoma. 2023-02-07T08:48:21Z 2023-02-07T08:48:21Z 2022 info:eu-repo/semantics/article https://hdl.handle.net/10171/65285 en info:eu-repo/grantAgreement/MSC/Redes Temáticas de Investigación Cooperativa en Salud (RETICS)/RD06%2F0045/ES/ALIMENTACIÓN SALUDABLE EN LA PREVENCIÓN PRIMARIA DE ENFERMEDADES CRÓNICAS: LA RED PREDIMED info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/RD06%2F0045/ES/EMPODERAMIENTO INTEGRAL PARA GANAR SALUD: ANALISIS LONGITUDINAL DE LA COHORTE SUN info:eu-repo/semantics/openAccess application/pdf |
| spellingShingle | Vitamin A Vitamin C Vitamin E Glaucoma SUN project Moreno-Montañes, J. (Javier) Gándara-Rodríguez-de-Campoamor, E. (Elsa) Moreno-Galarraga, L. (Laura) Hershey-de-la-Cruz, M.S. (María Soledad) López-Gil, J.F. (José Francisco) Kales, S.N. (Stefanos N.) Bes-Rastrollo, M. (Maira) Martinez-Gonzalez, M.A. (Miguel Ángel) Fernandez-Montero, A. (Alejandro) ACE-Vitamin Index and Risk of Glaucoma: the SUN Project |
| title | ACE-Vitamin Index and Risk of Glaucoma: the SUN Project |
| title_full | ACE-Vitamin Index and Risk of Glaucoma: the SUN Project |
| title_fullStr | ACE-Vitamin Index and Risk of Glaucoma: the SUN Project |
| title_full_unstemmed | ACE-Vitamin Index and Risk of Glaucoma: the SUN Project |
| title_short | ACE-Vitamin Index and Risk of Glaucoma: the SUN Project |
| title_sort | ace-vitamin index and risk of glaucoma: the sun project |
| topic | Vitamin A Vitamin C Vitamin E Glaucoma SUN project |
| url | https://hdl.handle.net/10171/65285 |
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