Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year
Systemic inflammation is associated with an increased risk of non-communicable diseases, such as cardiovascular diseases and diabetes. Circulating fatty acids (FA) are known to be related to these conditions, possibly through their role in inflammation, although different types of FAs can have oppos...
| Main Authors: | , , , , , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
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2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/65980 |
| _version_ | 1793400002084601856 |
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| author | Domínguez-López, I. (Inés) Arancibia-Riveros, C. (Camila) Casas, R. (Rosa) Tresserra-Rimbau, A. (Anna) Razquin, C. (Cristina) Martinez-Gonzalez, M.A. (Miguel Ángel) Hu, F.B. (Frank B.) Ros, E. (Emilio) Fito, M. (Montserrat) Estruch, R. (Ramón) Lopez-Sabater, M.C. (M. Carmen) Lamuela-Raventos, R.M. (Rosa Maria) |
| author_facet | Domínguez-López, I. (Inés) Arancibia-Riveros, C. (Camila) Casas, R. (Rosa) Tresserra-Rimbau, A. (Anna) Razquin, C. (Cristina) Martinez-Gonzalez, M.A. (Miguel Ángel) Hu, F.B. (Frank B.) Ros, E. (Emilio) Fito, M. (Montserrat) Estruch, R. (Ramón) Lopez-Sabater, M.C. (M. Carmen) Lamuela-Raventos, R.M. (Rosa Maria) |
| author_sort | Domínguez-López, I. (Inés) |
| collection | DSpace |
| description | Systemic inflammation is associated with an increased risk of non-communicable diseases, such as cardiovascular diseases and diabetes. Circulating fatty acids (FA) are known to be related to these conditions, possibly through their role in inflammation, although different types of FAs can have opposite effects on inflammatory mediators. The aim of the present study was to analyze the association of plasma FAs with inflammatory biomarkers in a PREDIMED trial subsample after one year of intervention. In a one-year longitudinal study of 91 participants of the PREDIMED trial (Barcelona-Clinic center), plasma FAs and inflammatory biomarkers were analyzed using gas chromatography and ELISA, respectively. In baseline plasma, a multivariable-adjusted ordinary least squares regression model showed that n-3 polyunsaturated FAs concentrations were inversely associated with concentrations of soluble intercellular adhesion molecule-1 (sICAM-1) and E-selectin, whereas the level of the most abundant saturated FA, palmitic acid, was directly associated with concentrations of interleukin-6 (IL-6) (beta = 0.48 pg/mL, 95% CI: 0.03, 0.93 per 1-SD increase, p-value = 0.037). After one year of nutritional intervention, changes of plasma diet-derived total saturated FAs and palmitic acid were directly associated with changes in IL6 (beta = 0.59 pg/mL [95% CI: 0.28, 0.89] per 1-SD, p-value = 0.001; beta = 0.64 pg/mL, 95% CI: 0.31, 0.98, p-value = 0.001), respectively, after correction for multiple testing. Our findings suggest that saturated FAs of dietary origin, especially palmitic acid, are directly involved in the increase of IL-6 in plasma. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-65980 |
| institution | Universidad de Navarra |
| language | English |
| publishDate | 2023 |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-659802023-06-19T05:17:17Z Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year Domínguez-López, I. (Inés) Arancibia-Riveros, C. (Camila) Casas, R. (Rosa) Tresserra-Rimbau, A. (Anna) Razquin, C. (Cristina) Martinez-Gonzalez, M.A. (Miguel Ángel) Hu, F.B. (Frank B.) Ros, E. (Emilio) Fito, M. (Montserrat) Estruch, R. (Ramón) Lopez-Sabater, M.C. (M. Carmen) Lamuela-Raventos, R.M. (Rosa Maria) Inflammation Fatty acids Mediterranean diet PREDIMED Longitudinal study Palmitic acid Systemic inflammation is associated with an increased risk of non-communicable diseases, such as cardiovascular diseases and diabetes. Circulating fatty acids (FA) are known to be related to these conditions, possibly through their role in inflammation, although different types of FAs can have opposite effects on inflammatory mediators. The aim of the present study was to analyze the association of plasma FAs with inflammatory biomarkers in a PREDIMED trial subsample after one year of intervention. In a one-year longitudinal study of 91 participants of the PREDIMED trial (Barcelona-Clinic center), plasma FAs and inflammatory biomarkers were analyzed using gas chromatography and ELISA, respectively. In baseline plasma, a multivariable-adjusted ordinary least squares regression model showed that n-3 polyunsaturated FAs concentrations were inversely associated with concentrations of soluble intercellular adhesion molecule-1 (sICAM-1) and E-selectin, whereas the level of the most abundant saturated FA, palmitic acid, was directly associated with concentrations of interleukin-6 (IL-6) (beta = 0.48 pg/mL, 95% CI: 0.03, 0.93 per 1-SD increase, p-value = 0.037). After one year of nutritional intervention, changes of plasma diet-derived total saturated FAs and palmitic acid were directly associated with changes in IL6 (beta = 0.59 pg/mL [95% CI: 0.28, 0.89] per 1-SD, p-value = 0.001; beta = 0.64 pg/mL, 95% CI: 0.31, 0.98, p-value = 0.001), respectively, after correction for multiple testing. Our findings suggest that saturated FAs of dietary origin, especially palmitic acid, are directly involved in the increase of IL-6 in plasma. 2023-04-18T10:02:09Z 2023-04-18T10:02:09Z 2022 info:eu-repo/semantics/article https://hdl.handle.net/10171/65980 en info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114022RB-I00/ES/DESARROLLO DE PRODUCTOS DE TOMATE SOSTENIBLES PARA MEJORAR EL EJE info:eu-repo/semantics/openAccess application/pdf |
| spellingShingle | Inflammation Fatty acids Mediterranean diet PREDIMED Longitudinal study Palmitic acid Domínguez-López, I. (Inés) Arancibia-Riveros, C. (Camila) Casas, R. (Rosa) Tresserra-Rimbau, A. (Anna) Razquin, C. (Cristina) Martinez-Gonzalez, M.A. (Miguel Ángel) Hu, F.B. (Frank B.) Ros, E. (Emilio) Fito, M. (Montserrat) Estruch, R. (Ramón) Lopez-Sabater, M.C. (M. Carmen) Lamuela-Raventos, R.M. (Rosa Maria) Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year |
| title | Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year |
| title_full | Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year |
| title_fullStr | Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year |
| title_full_unstemmed | Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year |
| title_short | Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year |
| title_sort | changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule il-6 concentrations after nutritional intervention for one year |
| topic | Inflammation Fatty acids Mediterranean diet PREDIMED Longitudinal study Palmitic acid |
| url | https://hdl.handle.net/10171/65980 |
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