Mid -and long-term changes in satiety-related hormones, lipid and glucose metabolism, and inflammation after a Mediterranean diet intervention with the goal of losing weight: a randomized, clinical trial
BackgroundObesity is produced by the enlargement of the adipose tissue. Functioning as an endocrine organ, it releases and receives information through a complex network of cytokines, hormones, and substrates contributing to a low-chronic inflammation environment. Diet and healthy habits play key ro...
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
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2023
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| Online Access: | https://hdl.handle.net/10171/65987 |
| _version_ | 1793400137941254144 |
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| author | Hernando-Redondo, J. (J.) Toloba, A. (A.) Benaiges, D. (D.) Salas-Salvado, J. (Jordi) Martinez-Gonzalez, M.A. (Miguel Ángel) Corella, D. (Dolores) Estruch, R. (Ramón) Tinahones, F.J. (Francisco J.) Ros, E. (Emilio) Goday, A. (Albert) Castañer, O. (Olga) Fito, M. (Montserrat) |
| author_facet | Hernando-Redondo, J. (J.) Toloba, A. (A.) Benaiges, D. (D.) Salas-Salvado, J. (Jordi) Martinez-Gonzalez, M.A. (Miguel Ángel) Corella, D. (Dolores) Estruch, R. (Ramón) Tinahones, F.J. (Francisco J.) Ros, E. (Emilio) Goday, A. (Albert) Castañer, O. (Olga) Fito, M. (Montserrat) |
| author_sort | Hernando-Redondo, J. (J.) |
| collection | DSpace |
| description | BackgroundObesity is produced by the enlargement of the adipose tissue. Functioning as an endocrine organ, it releases and receives information through a complex network of cytokines, hormones, and substrates contributing to a low-chronic inflammation environment. Diet and healthy habits play key roles in the prevention of obesity and its related pathologies. In this regard, there is a need to switch to healthier and more appetizing diets, such as the Mediterranean one. ObjectiveTo compare the mid-and long-term effects of two Mediterranean diet (MedDiet) interventions, one energy-reduced plus physical activity promotion versus a non-restrictive diet, on peripheral satiety-related hormones, weight loss, glucose/lipid metabolism, and pro-inflammatory markers in subjects with obesity/overweight and metabolic syndrome. Materials and methodsA randomized, lifestyle intervention was conducted in 23 Spanish centers, with a large cohort of patients presenting metabolic syndrome. Our study is a subproject set in IMIM (Hospital del Mar Research Institute). Participants were men and women, aged 55-75 and 60-75, respectively, who at baseline met at least three metabolic syndrome components. Subjects were assigned to two intervention groups: (1) an intensive lifestyle intervention with an energy-reduced MedDiet and physical activity promotion (intervention group) with the aim of weight loss; and (2) a normocaloric MedDiet (control). We quantified in a subsample of 300 volunteers from Hospital del Mar Research Institute (Barcelona), following analytes at baseline, 6 months, and 1 year: glucose, HbA1c, triglycerides, total cholesterol, high-density lipoprotein cholesterol, LDL cholesterol, C-peptide, ghrelin, GLP-1, glucagon, insulin, leptin, PAI-1, resistin, and visfatin. Anthropometric and classical cardiovascular risk factors were also determined. A multivariate statistical model was employed to compare the two groups. Linear mixed-effect models were performed to compare changes in risk factors and biomarkers between intervention groups and over time. ResultsCompared to participants in the control group, those in intervention one showed greater improvements in weight, waist circumference, insulin (P < 0.001), glucose metabolism-related compounds (P < 0.05), triglyceride-related lipid profile (P < 0.05), leptin, blood pressure, and pro-inflammatory markers such as PAI-1 (P < 0.001) at mid-and/or long-term. High-sensitivity C-reactive protein, resistin, and vifastin also decreased in both groups. ConclusionA weight loss intervention employing a hypocaloric MedDiet and physical activity promotion has beneficial effects on adiposity, glucose metabolism, lipid profile, leptin, and pro-inflammatory markers, such as PAI-1 in both mid-and long-term. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-65987 |
| institution | Universidad de Navarra |
| language | English |
| publishDate | 2023 |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-659872023-07-17T05:05:15Z Mid -and long-term changes in satiety-related hormones, lipid and glucose metabolism, and inflammation after a Mediterranean diet intervention with the goal of losing weight: a randomized, clinical trial Hernando-Redondo, J. (J.) Toloba, A. (A.) Benaiges, D. (D.) Salas-Salvado, J. (Jordi) Martinez-Gonzalez, M.A. (Miguel Ángel) Corella, D. (Dolores) Estruch, R. (Ramón) Tinahones, F.J. (Francisco J.) Ros, E. (Emilio) Goday, A. (Albert) Castañer, O. (Olga) Fito, M. (Montserrat) Metabolic syndrome Mediterranean diet (MedDiet) Leptin PAI-1 Inflammation BackgroundObesity is produced by the enlargement of the adipose tissue. Functioning as an endocrine organ, it releases and receives information through a complex network of cytokines, hormones, and substrates contributing to a low-chronic inflammation environment. Diet and healthy habits play key roles in the prevention of obesity and its related pathologies. In this regard, there is a need to switch to healthier and more appetizing diets, such as the Mediterranean one. ObjectiveTo compare the mid-and long-term effects of two Mediterranean diet (MedDiet) interventions, one energy-reduced plus physical activity promotion versus a non-restrictive diet, on peripheral satiety-related hormones, weight loss, glucose/lipid metabolism, and pro-inflammatory markers in subjects with obesity/overweight and metabolic syndrome. Materials and methodsA randomized, lifestyle intervention was conducted in 23 Spanish centers, with a large cohort of patients presenting metabolic syndrome. Our study is a subproject set in IMIM (Hospital del Mar Research Institute). Participants were men and women, aged 55-75 and 60-75, respectively, who at baseline met at least three metabolic syndrome components. Subjects were assigned to two intervention groups: (1) an intensive lifestyle intervention with an energy-reduced MedDiet and physical activity promotion (intervention group) with the aim of weight loss; and (2) a normocaloric MedDiet (control). We quantified in a subsample of 300 volunteers from Hospital del Mar Research Institute (Barcelona), following analytes at baseline, 6 months, and 1 year: glucose, HbA1c, triglycerides, total cholesterol, high-density lipoprotein cholesterol, LDL cholesterol, C-peptide, ghrelin, GLP-1, glucagon, insulin, leptin, PAI-1, resistin, and visfatin. Anthropometric and classical cardiovascular risk factors were also determined. A multivariate statistical model was employed to compare the two groups. Linear mixed-effect models were performed to compare changes in risk factors and biomarkers between intervention groups and over time. ResultsCompared to participants in the control group, those in intervention one showed greater improvements in weight, waist circumference, insulin (P < 0.001), glucose metabolism-related compounds (P < 0.05), triglyceride-related lipid profile (P < 0.05), leptin, blood pressure, and pro-inflammatory markers such as PAI-1 (P < 0.001) at mid-and/or long-term. High-sensitivity C-reactive protein, resistin, and vifastin also decreased in both groups. ConclusionA weight loss intervention employing a hypocaloric MedDiet and physical activity promotion has beneficial effects on adiposity, glucose metabolism, lipid profile, leptin, and pro-inflammatory markers, such as PAI-1 in both mid-and long-term. 2023-04-18T11:31:13Z 2023-04-18T11:31:13Z 2022 info:eu-repo/semantics/article https://hdl.handle.net/10171/65987 en info:eu-repo/grantAgreement/ISCIII/Proyectos de investigación en salud/ PI19/00017/ES/EFECTO DE UNA INTERVENCION INTENSIVA DE PERDIDA DE PESO CON DIETA MEDITERRANEA HIPOCALORICA, ACTIVIDAD FISICA Y TRATAMIENTO CONDUCTUAL SOBRE LA PREVENCION PRIMARIA CARDIOVASCULAR: ENSAYO PREDIMED-PLUS info:eu-repo/grantAgreement/MINECO/Proyectos de investigación en salud (Modalidad proyectos de investigación en salud) (AES 2015)/ PI15/00047/ES/Funcionalidad de la HDL en la predicción de eventos cardiovasculares en una cohorte a 5 años en población general. Estilo de vida como factor modulador info:eu-repo/grantAgreement/ISCIII/Proyectos de investigación en salud/PI18/00020/ES/EFECTO DE INTERVENCIONES SOBRE EL ESTILO DE VIDA, BASADAS EN DIETA Y ACTIVIDAD FISICA, SOBRE LA DISLIPEMIA ATEROGENICA EN PACIENTES CON SINDROME METABOLICO info:eu-repo/grantAgreement/MINECO/Proyectos de investigación en salud (Modalidad proyectos de investigación en salud) (AES 2015)/PI16/00533/ES/Efecto de una pérdida de peso con dieta mediterránea hipocalórica y promoción de la actividad física en la prevención primaria cardiovascular: Estudio PREDIMED-PLUS info:eu-repo/grantAgreement/MINECO/Proyectos de investigación en salud (AE en Salud)/PI13/00233/ES/PREDIMED-PLUS: Efecto de una dieta mediterránea hipocalórica y promoción de la actividad física en prevención primaria cardiovascular. Estudio piloto sobre marcadores intermedios info:eu-repo/grantAgreement/ISCIII/Proyectos de investigación en salud/PI21/00024/ES/ASOCIACION DE MICROARNS CON LA INCIDENCIA DE INFARTO DE MIOCARDIO; HDL SINTETIZADO RICO EN MIARN COMO ESTRATEGIA DE TRATAMIENTO info:eu-repo/grantAgreement/ISCIII/Proyectos de investigación en salud/PI20/00014/ES/BIOMARCADORES EMERGENTES DE RIESGO DE LA ENFERMEDAD DE ALZHEIMER: ESTADO PROCOAGULANTE, INFLAMACION DE ORIGEN INTESTINAL Y ADIPOQUINAS info:eu-repo/semantics/openAccess application/pdf |
| spellingShingle | Metabolic syndrome Mediterranean diet (MedDiet) Leptin PAI-1 Inflammation Hernando-Redondo, J. (J.) Toloba, A. (A.) Benaiges, D. (D.) Salas-Salvado, J. (Jordi) Martinez-Gonzalez, M.A. (Miguel Ángel) Corella, D. (Dolores) Estruch, R. (Ramón) Tinahones, F.J. (Francisco J.) Ros, E. (Emilio) Goday, A. (Albert) Castañer, O. (Olga) Fito, M. (Montserrat) Mid -and long-term changes in satiety-related hormones, lipid and glucose metabolism, and inflammation after a Mediterranean diet intervention with the goal of losing weight: a randomized, clinical trial |
| title | Mid -and long-term changes in satiety-related hormones, lipid and glucose metabolism, and inflammation after a Mediterranean diet intervention with the goal of losing weight: a randomized, clinical trial |
| title_full | Mid -and long-term changes in satiety-related hormones, lipid and glucose metabolism, and inflammation after a Mediterranean diet intervention with the goal of losing weight: a randomized, clinical trial |
| title_fullStr | Mid -and long-term changes in satiety-related hormones, lipid and glucose metabolism, and inflammation after a Mediterranean diet intervention with the goal of losing weight: a randomized, clinical trial |
| title_full_unstemmed | Mid -and long-term changes in satiety-related hormones, lipid and glucose metabolism, and inflammation after a Mediterranean diet intervention with the goal of losing weight: a randomized, clinical trial |
| title_short | Mid -and long-term changes in satiety-related hormones, lipid and glucose metabolism, and inflammation after a Mediterranean diet intervention with the goal of losing weight: a randomized, clinical trial |
| title_sort | mid -and long-term changes in satiety-related hormones, lipid and glucose metabolism, and inflammation after a mediterranean diet intervention with the goal of losing weight: a randomized, clinical trial |
| topic | Metabolic syndrome Mediterranean diet (MedDiet) Leptin PAI-1 Inflammation |
| url | https://hdl.handle.net/10171/65987 |
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