The defensive interactions of prominent infectious protozoan parasites: the host's complement system
The complement system exerts crucial functions both in innate immune responses and adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen invasions including protozoan parasites. Different pathogens including parasites have developed sophisticated strategies to defen...
| Main Authors: | , , , , , |
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| Format: | info:eu-repo/semantics/review |
| Language: | English |
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2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/66028 |
| _version_ | 1793400402534727680 |
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| author | Rashidi, S. (Sajad) Mansouri, R. (Reza) Ali-Hassanzadeh, M. (Mohammad) Muro, A. (Antonio) Nguewa-Kamsu, P.A. (Paul Alain) Manzano-Román, R. (Raúl) |
| author_facet | Rashidi, S. (Sajad) Mansouri, R. (Reza) Ali-Hassanzadeh, M. (Mohammad) Muro, A. (Antonio) Nguewa-Kamsu, P.A. (Paul Alain) Manzano-Román, R. (Raúl) |
| author_sort | Rashidi, S. (Sajad) |
| collection | DSpace |
| description | The complement system exerts crucial functions both in innate immune responses and adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen invasions including protozoan parasites. Different pathogens including parasites have developed sophisticated strategies to defend themselves against complement killing. Some of these strategies include the employment, mimicking or inhibition of host's complement regulatory proteins, leading to complement evasion. Therefore, parasites are proven to use the manipulation of the complement system to assist them during infection and persistence. Herein, we attempt to study the interaction's mechanisms of some prominent infectious protozoan parasites including Plasmodium, Toxoplasma, Trypanosoma, and Leishmania dealing with the complement system. Moreover, several crucial proteins that are expressed, recruited or hijacked by parasites and are involved in the modulation of the host's complement system are selected and their role for efficient complement killing or lysis evasion is discussed. In addition, parasite's complement regulatory proteins appear as plausible therapeutic and vaccine targets in protozoan parasitic infections. Accordingly, we also suggest some perspectives and insights useful in guiding future investigations. |
| format | info:eu-repo/semantics/review |
| id | oai:dadun.unav.edu:10171-66028 |
| institution | Universidad de Navarra |
| language | English |
| publishDate | 2023 |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-660282023-10-20T12:47:53Z The defensive interactions of prominent infectious protozoan parasites: the host's complement system Rashidi, S. (Sajad) Mansouri, R. (Reza) Ali-Hassanzadeh, M. (Mohammad) Muro, A. (Antonio) Nguewa-Kamsu, P.A. (Paul Alain) Manzano-Román, R. (Raúl) Protozoan parasites Complement system Complement regulatory proteins Complement evasion molecular interactions The complement system exerts crucial functions both in innate immune responses and adaptive humoral immunity. This pivotal system plays a major role dealing with pathogen invasions including protozoan parasites. Different pathogens including parasites have developed sophisticated strategies to defend themselves against complement killing. Some of these strategies include the employment, mimicking or inhibition of host's complement regulatory proteins, leading to complement evasion. Therefore, parasites are proven to use the manipulation of the complement system to assist them during infection and persistence. Herein, we attempt to study the interaction's mechanisms of some prominent infectious protozoan parasites including Plasmodium, Toxoplasma, Trypanosoma, and Leishmania dealing with the complement system. Moreover, several crucial proteins that are expressed, recruited or hijacked by parasites and are involved in the modulation of the host's complement system are selected and their role for efficient complement killing or lysis evasion is discussed. In addition, parasite's complement regulatory proteins appear as plausible therapeutic and vaccine targets in protozoan parasitic infections. Accordingly, we also suggest some perspectives and insights useful in guiding future investigations. 2023-04-19T13:59:14Z 2023-04-19T13:59:14Z 2022 info:eu-repo/semantics/review https://hdl.handle.net/10171/66028 en https://pubmed.ncbi.nlm.nih.gov/36358913/ info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-112713RB-C21/ES/EMBEDDING OF DRUGS IN POLYMERIC FIBERS FOR DERMAL RELEASE: APPLICATION TO THE TREATMENT OF CUTANEOUS LEISHMANIASIS AND SKIN INFECTIONS info:eu-repo/semantics/openAccess application/pdf |
| spellingShingle | Protozoan parasites Complement system Complement regulatory proteins Complement evasion molecular interactions Rashidi, S. (Sajad) Mansouri, R. (Reza) Ali-Hassanzadeh, M. (Mohammad) Muro, A. (Antonio) Nguewa-Kamsu, P.A. (Paul Alain) Manzano-Román, R. (Raúl) The defensive interactions of prominent infectious protozoan parasites: the host's complement system |
| title | The defensive interactions of prominent infectious protozoan parasites: the host's complement system |
| title_full | The defensive interactions of prominent infectious protozoan parasites: the host's complement system |
| title_fullStr | The defensive interactions of prominent infectious protozoan parasites: the host's complement system |
| title_full_unstemmed | The defensive interactions of prominent infectious protozoan parasites: the host's complement system |
| title_short | The defensive interactions of prominent infectious protozoan parasites: the host's complement system |
| title_sort | defensive interactions of prominent infectious protozoan parasites: the host's complement system |
| topic | Protozoan parasites Complement system Complement regulatory proteins Complement evasion molecular interactions |
| url | https://hdl.handle.net/10171/66028 |
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