Effect of dietary phenolic compounds on incidence of type 2 diabetes in the "Seguimiento Universidad de Navarra" (SUN) cohort
The global incidence of type 2 diabetes (T2D) has been steadily increasing in recent decades. The Mediterranean dietary pattern has shown a preventive effect on the risk of T2D. Evaluating the association between bioactive compounds such as phenolic compounds (PC) in a Mediterranean cohort could hel...
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
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2023
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| Online Access: | https://hdl.handle.net/10171/66052 |
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| author | Vazquez-Ruiz, Z. (Zenaida) Martinez-Gonzalez, M.A. (Miguel Ángel) Vitelli-Storelli, F. (Facundo) Bes-Rastrollo, M. (Maira) Basterra-Gortari, F.J. (Francisco Javier) Toledo, E. (Estefanía) |
| author_facet | Vazquez-Ruiz, Z. (Zenaida) Martinez-Gonzalez, M.A. (Miguel Ángel) Vitelli-Storelli, F. (Facundo) Bes-Rastrollo, M. (Maira) Basterra-Gortari, F.J. (Francisco Javier) Toledo, E. (Estefanía) |
| author_sort | Vazquez-Ruiz, Z. (Zenaida) |
| collection | DSpace |
| description | The global incidence of type 2 diabetes (T2D) has been steadily increasing in recent decades. The Mediterranean dietary pattern has shown a preventive effect on the risk of T2D. Evaluating the association between bioactive compounds such as phenolic compounds (PC) in a Mediterranean cohort could help to better understand the mechanisms implicated in this protection. We evaluated the association between dietary intake of PC and the risk of T2D in a relatively young cohort of 17,821 Spanish participants initially free of T2D, through the University of Navarra Follow-up Project (Seguimiento Universidad de Navarra or SUN cohort) after 10 years of median follow-up using time-dependent Cox models. Intake of PC was estimated at baseline and repeatedly at 10-year follow-up using a 136-item validated food frequency and the Phenol-Explorer database. The incidence of T2D was identified by a biennial follow-up, and only medically confirmed cases were included. During 224,751 person-years of follow-up, 186 cases of T2D were confirmed. A suboptimal intake of stilbenes was independently associated with a higher risk of T2D in subjects over 50 years (HR: 1.75, 95% CI: 1.06-2.90, p value < 0.05) after adjusting for potential confounders. Our results suggest that a moderate-high intake of stilbenes can decrease the risk of developing T2D in subjects over 50 years in our cohort. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-66052 |
| institution | Universidad de Navarra |
| language | English |
| publishDate | 2023 |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-660522023-06-26T05:18:20Z Effect of dietary phenolic compounds on incidence of type 2 diabetes in the "Seguimiento Universidad de Navarra" (SUN) cohort Vazquez-Ruiz, Z. (Zenaida) Martinez-Gonzalez, M.A. (Miguel Ángel) Vitelli-Storelli, F. (Facundo) Bes-Rastrollo, M. (Maira) Basterra-Gortari, F.J. (Francisco Javier) Toledo, E. (Estefanía) Phenolic compounds Diet Diabetes Stilbenes Cohort The global incidence of type 2 diabetes (T2D) has been steadily increasing in recent decades. The Mediterranean dietary pattern has shown a preventive effect on the risk of T2D. Evaluating the association between bioactive compounds such as phenolic compounds (PC) in a Mediterranean cohort could help to better understand the mechanisms implicated in this protection. We evaluated the association between dietary intake of PC and the risk of T2D in a relatively young cohort of 17,821 Spanish participants initially free of T2D, through the University of Navarra Follow-up Project (Seguimiento Universidad de Navarra or SUN cohort) after 10 years of median follow-up using time-dependent Cox models. Intake of PC was estimated at baseline and repeatedly at 10-year follow-up using a 136-item validated food frequency and the Phenol-Explorer database. The incidence of T2D was identified by a biennial follow-up, and only medically confirmed cases were included. During 224,751 person-years of follow-up, 186 cases of T2D were confirmed. A suboptimal intake of stilbenes was independently associated with a higher risk of T2D in subjects over 50 years (HR: 1.75, 95% CI: 1.06-2.90, p value < 0.05) after adjusting for potential confounders. Our results suggest that a moderate-high intake of stilbenes can decrease the risk of developing T2D in subjects over 50 years in our cohort. 2023-04-20T12:14:59Z 2023-04-20T12:14:59Z 2023 info:eu-repo/semantics/article https://hdl.handle.net/10171/66052 en info:eu-repo/grantAgreement/MSC/Redes Temáticas de Investigación Cooperativa en Salud (RETICS)/RD06%2F0045/ES/ALIMENTACIÓN SALUDABLE EN LA PREVENCIÓN PRIMARIA DE ENFERMEDADES CRÓNICAS: LA RED PREDIMED info:eu-repo/grantAgreement/MINECO/Proyectos de investigación en salud (AE en Salud)/PI13%2F00615/ES/ESTILOS DE VIDA Y RIESGO DE DIABETES MELLITUS GESTACIONAL: LA COHORTE SUN info:eu-repo/grantAgreement/MINECO/Proyectos de investigación en salud (AE Salud 2014)/PI14%2F01668/ES/Dieta y estilos de vida en la prevención de la diabetes mellitus gestacional: un proyecto coordinado de casos y controles y análisis prospectivo de un estudio de cohortes PI14/01798 info:eu-repo/grantAgreement/MINECO/Proyectos de investigación en salud (AE Salud 2014)/PI14%2F01798/ES/Patrones de dieta, de actividad física y de consumo de alcohol y riesgo de depresión en la cohorte SUN PI14/01764 info:eu-repo/grantAgreement/MINECO/Proyectos de investigación en salud (AE Salud 2014)/PI14%2F01764/ES/Prevención eficiente de la demencia en sujetos con alto riesgo info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01795/ES/ESTUDIO DE LA OBESIDAD COMO FACTOR DE RIESGO DE MORTALIDAD Y SU PREVENCION MEDIANTE RECOMENDACIONES DIETETICAS: ANALISIS LONGITUDINAL DE LA COHORTE SUN info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00564/ES/EMPODERAMIENTO INTEGRAL PARA GANAR SALUD: ANALISIS LONGITUDINAL DE LA COHORTE SUN info:eu-repo/grantAgreement/MINECO/Centros de Investigación Biomédica en Red (CIBER)/CB12%2F03%2F30017/ES/INCORPORACION GRUPOS CIBER FISIOPATOLOGIA DE LA OBESIDAD Y NUTRICION (CIBER OBN) info:eu-repo/semantics/openAccess application/pdf |
| spellingShingle | Phenolic compounds Diet Diabetes Stilbenes Cohort Vazquez-Ruiz, Z. (Zenaida) Martinez-Gonzalez, M.A. (Miguel Ángel) Vitelli-Storelli, F. (Facundo) Bes-Rastrollo, M. (Maira) Basterra-Gortari, F.J. (Francisco Javier) Toledo, E. (Estefanía) Effect of dietary phenolic compounds on incidence of type 2 diabetes in the "Seguimiento Universidad de Navarra" (SUN) cohort |
| title | Effect of dietary phenolic compounds on incidence of type 2 diabetes in the "Seguimiento Universidad de Navarra" (SUN) cohort |
| title_full | Effect of dietary phenolic compounds on incidence of type 2 diabetes in the "Seguimiento Universidad de Navarra" (SUN) cohort |
| title_fullStr | Effect of dietary phenolic compounds on incidence of type 2 diabetes in the "Seguimiento Universidad de Navarra" (SUN) cohort |
| title_full_unstemmed | Effect of dietary phenolic compounds on incidence of type 2 diabetes in the "Seguimiento Universidad de Navarra" (SUN) cohort |
| title_short | Effect of dietary phenolic compounds on incidence of type 2 diabetes in the "Seguimiento Universidad de Navarra" (SUN) cohort |
| title_sort | effect of dietary phenolic compounds on incidence of type 2 diabetes in the "seguimiento universidad de navarra" (sun) cohort |
| topic | Phenolic compounds Diet Diabetes Stilbenes Cohort |
| url | https://hdl.handle.net/10171/66052 |
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