Associations between overall, healthful, and unhealthful low-fat dietary patterns and breast cancer risk in a Mediterranean cohort: The SUN project
Objectives: Dietary patterns may have a greater influence on human health than individual foods or nutrients, and they are also of substantial interest in the field of breast cancer prevention. Beyond the adequate balance of macronutrients, evidence indicates that the quality of macronutrient sour...
| Main Authors: | , , , , , |
|---|---|
| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
Elsevier
2023
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/66158 |
| _version_ | 1793400069529010176 |
|---|---|
| author | Aguilera-Buenosvinos, I. (Inmaculada) Martinez-Gonzalez, M.A. (Miguel Ángel) Zazpe, I. (Itziar) Romanos-Nanclares, A. (Andrea) Sanchez-Bayona, R. (Rodrigo) Toledo, E. (Estefanía) |
| author_facet | Aguilera-Buenosvinos, I. (Inmaculada) Martinez-Gonzalez, M.A. (Miguel Ángel) Zazpe, I. (Itziar) Romanos-Nanclares, A. (Andrea) Sanchez-Bayona, R. (Rodrigo) Toledo, E. (Estefanía) |
| author_sort | Aguilera-Buenosvinos, I. (Inmaculada) |
| collection | DSpace |
| description | Objectives: Dietary patterns may have a greater influence on human health than individual foods or nutrients,
and they are also of substantial interest in the field of breast cancer prevention. Beyond the adequate balance
of macronutrients, evidence indicates that the quality of macronutrient sources may play an important role
in health outcomes. We sought to examine the relationship between healthful and unhealthful low-fat
dietary patterns in relation to breast cancer.
Methods: We used observational data from a Mediterranean cohort study (the Seguimiento Universidad de
Navarra project). We prospectively followed 10 930 middle-aged women initially free of breast cancer during
a median follow-up of 12.1 y. We calculated an overall, an unhealthful, and a healthful low-fat diet score,
based on a previously validated 136-item food frequency questionnaire and grouped participants into ter-
tiles. Incident breast cancer—overall and stratified by menopausal status—was the primary outcome. It was
self-reported by participants and confirmed based on medical reports or consultation of the National Death
Index. We used multivariable Cox regression models adjusted for potential confounders.
Results: During 123 297 person-years of follow-up, 150 cases of incident breast cancer were confirmed. No signifi-
cant associations were observed for overall or premenopausal breast cancer. For postmenopausal women, we
observed a significant association for moderate adherence to the unhealthful low-fat dietary score and postmeno-
pausal breast cancer (comparing tertile 2 to tertile 1; hazard ratio = 2.18; 95% confidence interval, 1.15 4.13).
Conclusions: In conclusion, no clear associations were observed, although more research is needed to address
the association between an unhealthful dietary pattern and postmenopausal breast cancer risk. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-66158 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-661582023-05-08T05:13:52Z Associations between overall, healthful, and unhealthful low-fat dietary patterns and breast cancer risk in a Mediterranean cohort: The SUN project Aguilera-Buenosvinos, I. (Inmaculada) Martinez-Gonzalez, M.A. (Miguel Ángel) Zazpe, I. (Itziar) Romanos-Nanclares, A. (Andrea) Sanchez-Bayona, R. (Rodrigo) Toledo, E. (Estefanía) Breast cancer Cohort Low-fat diet Dietary patterns Prospective cohort study Epidemiology Objectives: Dietary patterns may have a greater influence on human health than individual foods or nutrients, and they are also of substantial interest in the field of breast cancer prevention. Beyond the adequate balance of macronutrients, evidence indicates that the quality of macronutrient sources may play an important role in health outcomes. We sought to examine the relationship between healthful and unhealthful low-fat dietary patterns in relation to breast cancer. Methods: We used observational data from a Mediterranean cohort study (the Seguimiento Universidad de Navarra project). We prospectively followed 10 930 middle-aged women initially free of breast cancer during a median follow-up of 12.1 y. We calculated an overall, an unhealthful, and a healthful low-fat diet score, based on a previously validated 136-item food frequency questionnaire and grouped participants into ter- tiles. Incident breast cancer—overall and stratified by menopausal status—was the primary outcome. It was self-reported by participants and confirmed based on medical reports or consultation of the National Death Index. We used multivariable Cox regression models adjusted for potential confounders. Results: During 123 297 person-years of follow-up, 150 cases of incident breast cancer were confirmed. No signifi- cant associations were observed for overall or premenopausal breast cancer. For postmenopausal women, we observed a significant association for moderate adherence to the unhealthful low-fat dietary score and postmeno- pausal breast cancer (comparing tertile 2 to tertile 1; hazard ratio = 2.18; 95% confidence interval, 1.15 4.13). Conclusions: In conclusion, no clear associations were observed, although more research is needed to address the association between an unhealthful dietary pattern and postmenopausal breast cancer risk. 2023-05-03T10:27:39Z 2023-05-03T10:27:39Z 2023 info:eu-repo/semantics/article https://hdl.handle.net/10171/66158 eng info:eu-repo/semantics/openAccess application/pdf Elsevier |
| spellingShingle | Breast cancer Cohort Low-fat diet Dietary patterns Prospective cohort study Epidemiology Aguilera-Buenosvinos, I. (Inmaculada) Martinez-Gonzalez, M.A. (Miguel Ángel) Zazpe, I. (Itziar) Romanos-Nanclares, A. (Andrea) Sanchez-Bayona, R. (Rodrigo) Toledo, E. (Estefanía) Associations between overall, healthful, and unhealthful low-fat dietary patterns and breast cancer risk in a Mediterranean cohort: The SUN project |
| title | Associations between overall, healthful, and unhealthful low-fat dietary patterns and breast cancer risk in a Mediterranean cohort: The SUN project |
| title_full | Associations between overall, healthful, and unhealthful low-fat dietary patterns and breast cancer risk in a Mediterranean cohort: The SUN project |
| title_fullStr | Associations between overall, healthful, and unhealthful low-fat dietary patterns and breast cancer risk in a Mediterranean cohort: The SUN project |
| title_full_unstemmed | Associations between overall, healthful, and unhealthful low-fat dietary patterns and breast cancer risk in a Mediterranean cohort: The SUN project |
| title_short | Associations between overall, healthful, and unhealthful low-fat dietary patterns and breast cancer risk in a Mediterranean cohort: The SUN project |
| title_sort | associations between overall, healthful, and unhealthful low-fat dietary patterns and breast cancer risk in a mediterranean cohort: the sun project |
| topic | Breast cancer Cohort Low-fat diet Dietary patterns Prospective cohort study Epidemiology |
| url | https://hdl.handle.net/10171/66158 |
| work_keys_str_mv | AT aguilerabuenosvinosiinmaculada associationsbetweenoverallhealthfulandunhealthfullowfatdietarypatternsandbreastcancerriskinamediterraneancohortthesunproject AT martinezgonzalezmamiguelangel associationsbetweenoverallhealthfulandunhealthfullowfatdietarypatternsandbreastcancerriskinamediterraneancohortthesunproject AT zazpeiitziar associationsbetweenoverallhealthfulandunhealthfullowfatdietarypatternsandbreastcancerriskinamediterraneancohortthesunproject AT romanosnanclaresaandrea associationsbetweenoverallhealthfulandunhealthfullowfatdietarypatternsandbreastcancerriskinamediterraneancohortthesunproject AT sanchezbayonarrodrigo associationsbetweenoverallhealthfulandunhealthfullowfatdietarypatternsandbreastcancerriskinamediterraneancohortthesunproject AT toledoeestefania associationsbetweenoverallhealthfulandunhealthfullowfatdietarypatternsandbreastcancerriskinamediterraneancohortthesunproject |