DrugSniper, a Tool to Exploit Loss-Of-Function Screens, Identifies CREBBP as a Predictive Biomarker of VOLASERTIB in Small Cell Lung Carcinoma (SCLC)

DrugSniper, a Tool to Exploit Loss-Of-Function Screens, Identifies CREBBP as a Predictive Biomarker of VOLASERTIB in Small Cell Lung Carcinoma (SCLC)

The development of predictive biomarkers of response to targeted therapies is an unmet clinical need for many antitumoral agents. Recent genome-wide loss-of-function screens, such as RNA interference (RNAi) and CRISPR-Cas9 libraries, are an unprecedented resource to identify novel drug targets, r...

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Bibliographic Details
Main Authors: Carazo-Melo, F.(Fernando), Bertolo, C. (Cristina), Castilla, C. (Carlos), Cendoya-Garmendia, X. (Xabier), Campuzano, L. (Lucía), Serrano, D. (Diego), Gimeno, M. (Marian), Planes-Pedreño, F.J. (Francisco Javier), Pio, R. (Rubén), Montuenga-Badia, L.M. (Luis M.), Rubio, A. (Ángel)
Format: info:eu-repo/semantics/article
Language:eng
Published: 2023
Subjects:
Biomarker
Small cell lung carcinoma
SCLC
CREBBP
PLK1
Gene essentiality
Drug; treatment
DEMETER score
RNAi
Precision medicine
Drug repositioning
Online Access:https://hdl.handle.net/10171/66304

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