Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: a systematic review
Physical activity, particularly high-intensity eccentric muscle contractions, produces exercise-induced muscle damage (EIMD). The breakdown of muscle fibers and the consequent inflammatory responses derived from EIMD affect exercise performance. Curcumin, a natural polyphenol extracted from turme...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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MDPI AG
2023
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| Online Access: | https://hdl.handle.net/10171/66472 |
| _version_ | 1793400025263374336 |
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| author | Fernández-Lázaro, D. (Diego) Mielgo-Ayuso, J. (Juan) Seco-Calvo, J. (Jesús) Córdova-Martínez, A. (Alfredo) Caballero-García, A. (Alberto) Fernández-Lázaro, C.I. (César I.) |
| author_facet | Fernández-Lázaro, D. (Diego) Mielgo-Ayuso, J. (Juan) Seco-Calvo, J. (Jesús) Córdova-Martínez, A. (Alfredo) Caballero-García, A. (Alberto) Fernández-Lázaro, C.I. (César I.) |
| author_sort | Fernández-Lázaro, D. (Diego) |
| collection | DSpace |
| description | Physical activity, particularly high-intensity eccentric muscle contractions, produces
exercise-induced muscle damage (EIMD). The breakdown of muscle fibers and the consequent
inflammatory responses derived from EIMD affect exercise performance. Curcumin, a natural
polyphenol extracted from turmeric, has been shown to have mainly antioxidant and also
anti-inflammatory properties. This effect of curcumin could improve EIMD and exercise performance.
The main objective of this systematic review was to critically evaluate the effectiveness of curcumin
supplementation on EIMD and inflammatory and oxidative markers in a physically active population.
A structured search was carried out following Preferred Reporting Items for Systematic Review and
Meta-Analyses (PRISMA) guidelines in the databases SCOPUS, Web of Science (WOS), and Medline
(PubMed) from inception to October 2019. The search included original articles with randomized
controlled crossover or parallel design in which the intake of curcumin administered before and/or
after exercise was compared with an identical placebo situation. No filters were applied to the type of
physical exercise performed, the sex or the age of the participants. Of the 301 articles identified in the
search, 11 met the established criteria and were included in this systematic review. The methodological
quality of the studies was assessed using the McMaster Critical Review Form. The use of curcumin
reduces the subjective perception of the intensity of muscle pain; reduces muscle damage through the
decrease of creatine kinase (CK); increases muscle performance; has an anti-inflammatory effect by
modulating the pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-8; and may have a slight
antioxidant effect. In summary, the administration of curcumin at a dose between 150–1500 mg/day
before and during exercise, and up until 72 h’ post-exercise, improved performance by reducing
EIMD and modulating the inflammation caused by physical activity. In addition, humans appear to
be able to tolerate high doses of curcumin without significant side-effects. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-66472 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2023 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-664722023-06-05T05:10:31Z Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: a systematic review Fernández-Lázaro, D. (Diego) Mielgo-Ayuso, J. (Juan) Seco-Calvo, J. (Jesús) Córdova-Martínez, A. (Alfredo) Caballero-García, A. (Alberto) Fernández-Lázaro, C.I. (César I.) Natural polyphenols Curcumin Muscle-damaging exercise Anti-inflammatory Antioxidants Physical activity Physical activity, particularly high-intensity eccentric muscle contractions, produces exercise-induced muscle damage (EIMD). The breakdown of muscle fibers and the consequent inflammatory responses derived from EIMD affect exercise performance. Curcumin, a natural polyphenol extracted from turmeric, has been shown to have mainly antioxidant and also anti-inflammatory properties. This effect of curcumin could improve EIMD and exercise performance. The main objective of this systematic review was to critically evaluate the effectiveness of curcumin supplementation on EIMD and inflammatory and oxidative markers in a physically active population. A structured search was carried out following Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines in the databases SCOPUS, Web of Science (WOS), and Medline (PubMed) from inception to October 2019. The search included original articles with randomized controlled crossover or parallel design in which the intake of curcumin administered before and/or after exercise was compared with an identical placebo situation. No filters were applied to the type of physical exercise performed, the sex or the age of the participants. Of the 301 articles identified in the search, 11 met the established criteria and were included in this systematic review. The methodological quality of the studies was assessed using the McMaster Critical Review Form. The use of curcumin reduces the subjective perception of the intensity of muscle pain; reduces muscle damage through the decrease of creatine kinase (CK); increases muscle performance; has an anti-inflammatory effect by modulating the pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-8; and may have a slight antioxidant effect. In summary, the administration of curcumin at a dose between 150–1500 mg/day before and during exercise, and up until 72 h’ post-exercise, improved performance by reducing EIMD and modulating the inflammation caused by physical activity. In addition, humans appear to be able to tolerate high doses of curcumin without significant side-effects. 2023-05-30T10:10:50Z 2023-05-30T10:10:50Z 2020 info:eu-repo/semantics/article https://hdl.handle.net/10171/66472 eng info:eu-repo/semantics/openAccess application/pdf MDPI AG |
| spellingShingle | Natural polyphenols Curcumin Muscle-damaging exercise Anti-inflammatory Antioxidants Physical activity Fernández-Lázaro, D. (Diego) Mielgo-Ayuso, J. (Juan) Seco-Calvo, J. (Jesús) Córdova-Martínez, A. (Alfredo) Caballero-García, A. (Alberto) Fernández-Lázaro, C.I. (César I.) Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: a systematic review |
| title | Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: a systematic review |
| title_full | Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: a systematic review |
| title_fullStr | Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: a systematic review |
| title_full_unstemmed | Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: a systematic review |
| title_short | Modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: a systematic review |
| title_sort | modulation of exercise-induced muscle damage, inflammation, and oxidative markers by curcumin supplementation in a physically active population: a systematic review |
| topic | Natural polyphenols Curcumin Muscle-damaging exercise Anti-inflammatory Antioxidants Physical activity |
| url | https://hdl.handle.net/10171/66472 |
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