| Summary: | Health related quality of life (HRQoL) is a subjective appreciation of how personal
characteristics and health influence well-being. This cross-sectional analysis aimed to quantitatively
measure the influence of dietary, lifestyle, and demographic factors on HRQoL. A sub-sample of
the Seguimiento Universidad de Navarra (SUN) Project, a Mediterranean cohort, was analyzed
(n = 15,674). Through self-administered questionnaires the relationship between HRQoL and dietary
patterns (Mediterranean-diet (MedDiet) and provegetarian food pattern (FP) assessment), lifestyles
(sleeping hours, physical activity) and demographic characteristics were measured. Multivariate linear
regression and flexible regression models were used to estimate the pondered effect of personal factors
on Short Form-36 (SF-36) scores. Coefficients for MedDiet and provegetarian scores (β-coefficient for
global SF-36 score: 0.32 (0.22, 0.42); 0.09 (0.06, 0.12) respectively for every unit increase), physical
activity (β: 0.03 (0.02, 0.03) for every metabolic equivalent of task indexes (MET)-h/week) had a
positive association to HRQoL. The female sex (β: −3.28 (−3.68, −2.89)), and pre-existing diseases
(diabetes, β: −2.27 (−3.48, −1.06), hypertension β: −1.79 (−2.36, −1.22), hypercholesterolemia β: −1.04
(−1.48, −0.59)) account for lower SF-36 scores. Adherence to MedDiet or provegetarian FP, physical
activity and sleep are associated with higher HRQoL, whereas the female sex, “other” (versus married
status) and the presence of chronic diseases were associated with lower SF-36 scores in this sample.
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