SUCCOR Nodes: May Sentinel Node Biopsy Determine the Need for Adjuvant Treatment?
Background The SUCCOR cohort was developed to analyse the overall and disease-free survival at 5 years in women with FIGO 2009 stage IB1 cervical cancer. The aim of this study was to compare the use of adjuvant therapy in these women, depending on the method used to diagnose lymphatic node metastas...
| Main Authors: | , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Springer
2023
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| Online Access: | https://hdl.handle.net/10171/67263 |
| _version_ | 1793400184126832640 |
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| author | Berasaluce, A. (Arantxa) Martin-Calvo, N. (Nerea) Boria, F. (Félix) Manzour, N. (Nabil) Chacón, E. (Enrique) Bizzarri, N. (Nicolò) Chiva, L. (Luis) |
| author_facet | Berasaluce, A. (Arantxa) Martin-Calvo, N. (Nerea) Boria, F. (Félix) Manzour, N. (Nabil) Chacón, E. (Enrique) Bizzarri, N. (Nicolò) Chiva, L. (Luis) |
| author_sort | Berasaluce, A. (Arantxa) |
| collection | DSpace |
| description | Background
The SUCCOR cohort was developed to analyse the overall and disease-free survival at 5 years in women with FIGO 2009 stage IB1 cervical cancer. The aim of this study was to compare the use of adjuvant therapy in these women, depending on the method used to diagnose lymphatic node metastasis.
Patients and Methods
We used data from the SUCCOR cohort, which collected information from 1049 women with FIGO 2009 stage IB1 cervical cancer who were operated on between January 2013 and December 2014 in Europe. We calculated the adjusted proportion of women who received adjuvant therapy depending on the lymph node diagnosis method and compared disease free and overall survival using Cox proportional-hazards regression models. Inverse probability weighting was used to adjust for baseline potential confounders.
Results
The adjusted proportion of women who received adjuvant therapy was 33.8% in the sentinel node biopsy + lymphadenectomy (SNB+LA) group and 44.7% in the LA group (p = 0.02), although the proportion of positive nodal status was similar (p = 0.30). That difference was greater in women with negative nodal status and positive Sedlis criteria (difference 31.2%, p = 0.01). Here, those who underwent a SNB+LA had an increased risk of relapse [hazard ratio (HR) 2.49, 95% confidence interval (CI) 0.98–6.33, p = 0.056] and risk of death (HR 3.49, 95% CI 1.04–11.7, p = 0.042) compared with those who underwent LA.
Conclusions
Women in this study were less likely to receive adjuvant therapy if their nodal invasion was determined using SNB+LA compared with LA. These results suggest a lack of therapeutic measures available when a negative result is obtained by SNB+LA, which may have an impact on the risk of recurrence and survival. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-67263 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2023 |
| publisher | Springer |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-672632023-09-25T05:05:20Z SUCCOR Nodes: May Sentinel Node Biopsy Determine the Need for Adjuvant Treatment? Berasaluce, A. (Arantxa) Martin-Calvo, N. (Nerea) Boria, F. (Félix) Manzour, N. (Nabil) Chacón, E. (Enrique) Bizzarri, N. (Nicolò) Chiva, L. (Luis) Materias Investigacion::Ciencias de la Salud::Medicina preventiva Materias Investigacion::Ciencias de la Salud Materias Investigacion::Ciencias de la Salud::Obstetricia y ginecología Background The SUCCOR cohort was developed to analyse the overall and disease-free survival at 5 years in women with FIGO 2009 stage IB1 cervical cancer. The aim of this study was to compare the use of adjuvant therapy in these women, depending on the method used to diagnose lymphatic node metastasis. Patients and Methods We used data from the SUCCOR cohort, which collected information from 1049 women with FIGO 2009 stage IB1 cervical cancer who were operated on between January 2013 and December 2014 in Europe. We calculated the adjusted proportion of women who received adjuvant therapy depending on the lymph node diagnosis method and compared disease free and overall survival using Cox proportional-hazards regression models. Inverse probability weighting was used to adjust for baseline potential confounders. Results The adjusted proportion of women who received adjuvant therapy was 33.8% in the sentinel node biopsy + lymphadenectomy (SNB+LA) group and 44.7% in the LA group (p = 0.02), although the proportion of positive nodal status was similar (p = 0.30). That difference was greater in women with negative nodal status and positive Sedlis criteria (difference 31.2%, p = 0.01). Here, those who underwent a SNB+LA had an increased risk of relapse [hazard ratio (HR) 2.49, 95% confidence interval (CI) 0.98–6.33, p = 0.056] and risk of death (HR 3.49, 95% CI 1.04–11.7, p = 0.042) compared with those who underwent LA. Conclusions Women in this study were less likely to receive adjuvant therapy if their nodal invasion was determined using SNB+LA compared with LA. These results suggest a lack of therapeutic measures available when a negative result is obtained by SNB+LA, which may have an impact on the risk of recurrence and survival. 2023-09-20T11:50:15Z 2023-09-20T11:50:15Z 2023 info:eu-repo/semantics/article https://hdl.handle.net/10171/67263 eng info:eu-repo/semantics/openAccess application/pdf Springer |
| spellingShingle | Materias Investigacion::Ciencias de la Salud::Medicina preventiva Materias Investigacion::Ciencias de la Salud Materias Investigacion::Ciencias de la Salud::Obstetricia y ginecología Berasaluce, A. (Arantxa) Martin-Calvo, N. (Nerea) Boria, F. (Félix) Manzour, N. (Nabil) Chacón, E. (Enrique) Bizzarri, N. (Nicolò) Chiva, L. (Luis) SUCCOR Nodes: May Sentinel Node Biopsy Determine the Need for Adjuvant Treatment? |
| title | SUCCOR Nodes: May Sentinel Node Biopsy Determine the Need for Adjuvant Treatment? |
| title_full | SUCCOR Nodes: May Sentinel Node Biopsy Determine the Need for Adjuvant Treatment? |
| title_fullStr | SUCCOR Nodes: May Sentinel Node Biopsy Determine the Need for Adjuvant Treatment? |
| title_full_unstemmed | SUCCOR Nodes: May Sentinel Node Biopsy Determine the Need for Adjuvant Treatment? |
| title_short | SUCCOR Nodes: May Sentinel Node Biopsy Determine the Need for Adjuvant Treatment? |
| title_sort | succor nodes: may sentinel node biopsy determine the need for adjuvant treatment? |
| topic | Materias Investigacion::Ciencias de la Salud::Medicina preventiva Materias Investigacion::Ciencias de la Salud Materias Investigacion::Ciencias de la Salud::Obstetricia y ginecología |
| url | https://hdl.handle.net/10171/67263 |
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