Risk for cardiovascular disease associated with metabolic syndrome and its components: a 13-year prospective study in the RIVANA cohort
Background We aimed to investigate the association of metabolic syndrome (MetS) and its single components with cardiovascular risk and estimated their impact on the prematurity of occurrence of cardiovascular events using rate advancement periods (RAPs). Methods We performed prospective analyse...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Springer Nature
2023
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| Online Access: | https://hdl.handle.net/10171/67884 |
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| author | Guembe, M.J. (María Jesús) Fernández-Lázaro, C.I. (César I.) Sayon-Orea, C. (Carmen) Toledo, E. (Estefanía) Moreno-Iribas, C. (Conchi) |
| author_facet | Guembe, M.J. (María Jesús) Fernández-Lázaro, C.I. (César I.) Sayon-Orea, C. (Carmen) Toledo, E. (Estefanía) Moreno-Iribas, C. (Conchi) |
| author_sort | Guembe, M.J. (María Jesús) |
| collection | DSpace |
| description | Background
We aimed to investigate the association of metabolic syndrome (MetS) and its single components with cardiovascular risk and estimated their impact on the prematurity of occurrence of cardiovascular events using rate advancement periods (RAPs).
Methods
We performed prospective analyses among 3976 participants (age range: 35–84, 55% female) in the Vascular Risk in Navarre (RIVANA) Study, a Mediterranean population-based cohort. MetS was defined based on the modified criteria of the American Heart Association/National Heart, Lung, and Blood Institute and the International Diabetes Federation. The primary endpoint was major cardiovascular event (a composite of myocardial infarction, stroke, or mortality from cardiovascular causes). Secondary endpoints were incidence of non-fatal myocardial infarction and non-fatal stroke, cardiovascular mortality, and all-cause mortality. Cox proportional hazards models, adjusted for potential confounders, were fitted to evaluate the association between MetS and its single components at baseline with primary and secondary endpoints.
Results
During a median follow-up of 12.8 years (interquartile range, 12.5–13.1), we identified 228 primary endpoint events. MetS was associated with higher risk of incidence of major cardiovascular event, cardiovascular and all-cause mortality, but was neither associated with higher risk of myocardial infarction nor stroke. Compared with participants without MetS, the multivariable hazard ratio (95% confidence interval [CI]) among participants with MetS was 1.32 (1.01–1.74) with RAP (95% CI) of 3.23 years (0.03, 6.42) for major cardiovascular event, 1.64 (1.03–2.60) with RAP of 3.73 years (0.02, 7.45) for cardiovascular mortality, and 1.45 (1.17–1.80) with RAP of 3.24 years (1.21, 5.27) for all-cause mortality. The magnitude of the associations of the single components of MetS was similar than the predicted by MetS. Additionally, for each additional trait of MetS, incidence of major cardiovascular event relatively increased by 22% (1.22, 95% CI 1.09–1.36) with RAP of 2.31 years (0.88, 3.74).
Conclusions
MetS was independently associated with CVD risk, cardiovascular and all-cause mortality. Components of the MetS were associated with similar magnitude of increased CVD, which suggests that MetS was not in excess of the level explained by the presence of its single components. Further research should explore the association of different combinations of the components of MetS with CVD. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-67884 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2023 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-678842023-11-27T06:05:47Z Risk for cardiovascular disease associated with metabolic syndrome and its components: a 13-year prospective study in the RIVANA cohort Guembe, M.J. (María Jesús) Fernández-Lázaro, C.I. (César I.) Sayon-Orea, C. (Carmen) Toledo, E. (Estefanía) Moreno-Iribas, C. (Conchi) Cardiovascular disease Metabolic syndrome Myocardial infarction Stroke Cardiovascular mortality Mediterranean cohort Cohort study Background We aimed to investigate the association of metabolic syndrome (MetS) and its single components with cardiovascular risk and estimated their impact on the prematurity of occurrence of cardiovascular events using rate advancement periods (RAPs). Methods We performed prospective analyses among 3976 participants (age range: 35–84, 55% female) in the Vascular Risk in Navarre (RIVANA) Study, a Mediterranean population-based cohort. MetS was defined based on the modified criteria of the American Heart Association/National Heart, Lung, and Blood Institute and the International Diabetes Federation. The primary endpoint was major cardiovascular event (a composite of myocardial infarction, stroke, or mortality from cardiovascular causes). Secondary endpoints were incidence of non-fatal myocardial infarction and non-fatal stroke, cardiovascular mortality, and all-cause mortality. Cox proportional hazards models, adjusted for potential confounders, were fitted to evaluate the association between MetS and its single components at baseline with primary and secondary endpoints. Results During a median follow-up of 12.8 years (interquartile range, 12.5–13.1), we identified 228 primary endpoint events. MetS was associated with higher risk of incidence of major cardiovascular event, cardiovascular and all-cause mortality, but was neither associated with higher risk of myocardial infarction nor stroke. Compared with participants without MetS, the multivariable hazard ratio (95% confidence interval [CI]) among participants with MetS was 1.32 (1.01–1.74) with RAP (95% CI) of 3.23 years (0.03, 6.42) for major cardiovascular event, 1.64 (1.03–2.60) with RAP of 3.73 years (0.02, 7.45) for cardiovascular mortality, and 1.45 (1.17–1.80) with RAP of 3.24 years (1.21, 5.27) for all-cause mortality. The magnitude of the associations of the single components of MetS was similar than the predicted by MetS. Additionally, for each additional trait of MetS, incidence of major cardiovascular event relatively increased by 22% (1.22, 95% CI 1.09–1.36) with RAP of 2.31 years (0.88, 3.74). Conclusions MetS was independently associated with CVD risk, cardiovascular and all-cause mortality. Components of the MetS were associated with similar magnitude of increased CVD, which suggests that MetS was not in excess of the level explained by the presence of its single components. Further research should explore the association of different combinations of the components of MetS with CVD. 2023-11-21T08:16:17Z 2023-11-21T08:16:17Z 2020 info:eu-repo/semantics/article https://hdl.handle.net/10171/67884 eng info:eu-repo/semantics/openAccess application/pdf Springer Nature |
| spellingShingle | Cardiovascular disease Metabolic syndrome Myocardial infarction Stroke Cardiovascular mortality Mediterranean cohort Cohort study Guembe, M.J. (María Jesús) Fernández-Lázaro, C.I. (César I.) Sayon-Orea, C. (Carmen) Toledo, E. (Estefanía) Moreno-Iribas, C. (Conchi) Risk for cardiovascular disease associated with metabolic syndrome and its components: a 13-year prospective study in the RIVANA cohort |
| title | Risk for cardiovascular disease associated with metabolic syndrome and its components: a 13-year prospective study in the RIVANA cohort |
| title_full | Risk for cardiovascular disease associated with metabolic syndrome and its components: a 13-year prospective study in the RIVANA cohort |
| title_fullStr | Risk for cardiovascular disease associated with metabolic syndrome and its components: a 13-year prospective study in the RIVANA cohort |
| title_full_unstemmed | Risk for cardiovascular disease associated with metabolic syndrome and its components: a 13-year prospective study in the RIVANA cohort |
| title_short | Risk for cardiovascular disease associated with metabolic syndrome and its components: a 13-year prospective study in the RIVANA cohort |
| title_sort | risk for cardiovascular disease associated with metabolic syndrome and its components: a 13-year prospective study in the rivana cohort |
| topic | Cardiovascular disease Metabolic syndrome Myocardial infarction Stroke Cardiovascular mortality Mediterranean cohort Cohort study |
| url | https://hdl.handle.net/10171/67884 |
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