Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort
Purpose We aimed to prospectively investigate the association of an overall oxidative balance score (OBS) with all-cause death and cause-specifc mortality among participants in the Seguimiento Universidad de Navarra (SUN) Study, a Mediterranean cohort of Spanish graduates. Methods Using baseline i...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Springer
2023
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| Online Access: | https://hdl.handle.net/10171/67901 |
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| author | Talavera-Rodríguez, I. (Irene) Fernández-Lázaro, C.I. (César I.) Hernández-Ruiz, Á, (Ángela) Hershey-de-la-Cruz, M.S. (María Soledad) Galarregui-Miquelarena, C. (Cristina) Sotos-Prieto, M. (Mercedes) Fuente-Arrillaga, C. (Carmen) de la Martinez-Gonzalez, M.A. (Miguel Ángel) Ruiz-Canela, M. (Miguel) |
| author_facet | Talavera-Rodríguez, I. (Irene) Fernández-Lázaro, C.I. (César I.) Hernández-Ruiz, Á, (Ángela) Hershey-de-la-Cruz, M.S. (María Soledad) Galarregui-Miquelarena, C. (Cristina) Sotos-Prieto, M. (Mercedes) Fuente-Arrillaga, C. (Carmen) de la Martinez-Gonzalez, M.A. (Miguel Ángel) Ruiz-Canela, M. (Miguel) |
| author_sort | Talavera-Rodríguez, I. (Irene) |
| collection | DSpace |
| description | Purpose We aimed to prospectively investigate the association of an overall oxidative balance score (OBS) with all-cause
death and cause-specifc mortality among participants in the Seguimiento Universidad de Navarra (SUN) Study, a Mediterranean cohort of Spanish graduates.
Methods Using baseline information on 12 a priori selected dietary and non-dietary lifestyle pro- and antioxidants exposures—vitamins C and E, β-carotenes, selenium, zinc, heme iron, polyphenols, total antioxidant capacity, body mass index,
alcohol, smoking, and physical activity—we constructed an equally weighted OBS categorized into quartiles, with higher
scores representing greater antioxidant balance. Cox proportional hazards models were ftted to evaluate the association
between the OBS and mortality.
Results A total of 18,561 participants (mean [SD] age, 38.5 [12.4] years; 40.8% males) were included in the analysis. During a median follow-up of 12.2 years (interquartile range 8.3–14.9), 421 deaths were identifed, including 80 deaths from
cardiovascular disease (CVD), 215 from cancer, and 126 from other causes. After adjustment for potential confounders,
the hazard ratios and 95% confdence interval (CIs) between the highest quartile (predominance of antioxidants) vs. the
lowest quartile (reference category) were 0.35 (95% CI 0.22–0.54, P-trend<0.001) for all-cause mortality, 0.18 (95% CI
0.06–0.51, P-trend=0.001) for CVD mortality, 0.35 (95% CI 0.19–0.65, P-trend=0.002) for cancer mortality, and 0.45
(95% CI 0.20–1.02, P-trend=0.054) for other-cause mortality.
Conclusion Our fndings suggest a strong inverse association between the OBS and all-cause, CVD, and cancer mortality.
Individuals exposed to both antioxidant dietary and lifestyle factors may potentially experience the lowest mortality risk. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-67901 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2023 |
| publisher | Springer |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-679012023-11-27T06:06:22Z Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort Talavera-Rodríguez, I. (Irene) Fernández-Lázaro, C.I. (César I.) Hernández-Ruiz, Á, (Ángela) Hershey-de-la-Cruz, M.S. (María Soledad) Galarregui-Miquelarena, C. (Cristina) Sotos-Prieto, M. (Mercedes) Fuente-Arrillaga, C. (Carmen) de la Martinez-Gonzalez, M.A. (Miguel Ángel) Ruiz-Canela, M. (Miguel) Oxidative balance score Oxidative stress Mortality Diet Lifestyle Dietary antioxidants Purpose We aimed to prospectively investigate the association of an overall oxidative balance score (OBS) with all-cause death and cause-specifc mortality among participants in the Seguimiento Universidad de Navarra (SUN) Study, a Mediterranean cohort of Spanish graduates. Methods Using baseline information on 12 a priori selected dietary and non-dietary lifestyle pro- and antioxidants exposures—vitamins C and E, β-carotenes, selenium, zinc, heme iron, polyphenols, total antioxidant capacity, body mass index, alcohol, smoking, and physical activity—we constructed an equally weighted OBS categorized into quartiles, with higher scores representing greater antioxidant balance. Cox proportional hazards models were ftted to evaluate the association between the OBS and mortality. Results A total of 18,561 participants (mean [SD] age, 38.5 [12.4] years; 40.8% males) were included in the analysis. During a median follow-up of 12.2 years (interquartile range 8.3–14.9), 421 deaths were identifed, including 80 deaths from cardiovascular disease (CVD), 215 from cancer, and 126 from other causes. After adjustment for potential confounders, the hazard ratios and 95% confdence interval (CIs) between the highest quartile (predominance of antioxidants) vs. the lowest quartile (reference category) were 0.35 (95% CI 0.22–0.54, P-trend<0.001) for all-cause mortality, 0.18 (95% CI 0.06–0.51, P-trend=0.001) for CVD mortality, 0.35 (95% CI 0.19–0.65, P-trend=0.002) for cancer mortality, and 0.45 (95% CI 0.20–1.02, P-trend=0.054) for other-cause mortality. Conclusion Our fndings suggest a strong inverse association between the OBS and all-cause, CVD, and cancer mortality. Individuals exposed to both antioxidant dietary and lifestyle factors may potentially experience the lowest mortality risk. 2023-11-21T09:13:03Z 2023-11-21T09:13:03Z 2023 info:eu-repo/semantics/article https://hdl.handle.net/10171/67901 eng info:eu-repo/grantAgreement/MSC/Redes Temáticas de Investigación Cooperativa en Salud (RETICS)/RD 06/0045/[ES]/ALIMENTACIÓN SALUDABLE EN LA PREVENCIÓN PRIMARIA DE ENFERMEDADES CRÓNICAS: LA RED PREDIMED info:eu-repo/grantAgreement/MINECO/Proyectos de investigación en salud (AE en Salud)/PI13/00615/[ES]/ESTILOS DE VIDA Y RIESGO DE DIABETES MELLITUS GESTACIONAL: LA COHORTE SUN info:eu-repo/grantAgreement/MINECO/Proyectos de investigación en salud (AE Salud 2014)/PI14/01668/[ES]/Dieta y estilos de vida en la prevención de la diabetes mellitus gestacional: un proyecto coordinado de casos y controles y análisis prospectivo de un estudio de cohortes info:eu-repo/grantAgreement/MINECO/Proyectos de investigación en salud (AE Salud 2014)/PI14/01798/[ES]/Patrones de dieta, de actividad física y de consumo de alcohol y riesgo de depresión en la cohorte SUN info:eu-repo/grantAgreement/MINECO/Proyectos de investigación en salud (AE Salud 2014)/PI14/01764/[ES]/Prevención eficiente de la demencia en sujetos con alto riesgo info:eu-repo/grantAgreement/ISCIII/Proyectos de investigación en salud/PI17/01795/[ES]/ESTUDIO DE LA OBESIDAD COMO FACTOR DE RIESGO DE MORTALIDAD Y SU PREVENCION MEDIANTE RECOMENDACIONES DIETETICAS: ANALISIS LONGITUDINAL DE LA COHORTE SUN info:eu-repo/semantics/openAccess application/pdf Springer |
| spellingShingle | Oxidative balance score Oxidative stress Mortality Diet Lifestyle Dietary antioxidants Talavera-Rodríguez, I. (Irene) Fernández-Lázaro, C.I. (César I.) Hernández-Ruiz, Á, (Ángela) Hershey-de-la-Cruz, M.S. (María Soledad) Galarregui-Miquelarena, C. (Cristina) Sotos-Prieto, M. (Mercedes) Fuente-Arrillaga, C. (Carmen) de la Martinez-Gonzalez, M.A. (Miguel Ángel) Ruiz-Canela, M. (Miguel) Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort |
| title | Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort |
| title_full | Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort |
| title_fullStr | Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort |
| title_full_unstemmed | Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort |
| title_short | Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort |
| title_sort | association between an oxidative balance score and mortality: a prospective analysis in the sun cohort |
| topic | Oxidative balance score Oxidative stress Mortality Diet Lifestyle Dietary antioxidants |
| url | https://hdl.handle.net/10171/67901 |
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