Congenital cytomegalovirus infection with brainstem hemorrhage and polymicrogyria: Necropsic and histopathological findings
Congenital cytomegalovirus (CMV) infection can cause severe neurological sequelae or even fetal death. We present a 17-year-old pregnant woman with fetal CMV infection, leading to voluntary termination of pregnancy. Fetopsy demonstrated a brainstem hemorrhage and focal polymicrogyria. CMV inclusions...
| Main Authors: | , , , , |
|---|---|
| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
Wiley
2023
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/68174 |
| _version_ | 1793400093311762432 |
|---|---|
| author | Arredondo-Montero, J. (Javier) Bronte-Anaut, M. (Mónica) Caballero, M.C. (M.C.) Fernández-Seara, M.P. (María del Pilar) Martin-Calvo, N. (Nerea) |
| author_facet | Arredondo-Montero, J. (Javier) Bronte-Anaut, M. (Mónica) Caballero, M.C. (M.C.) Fernández-Seara, M.P. (María del Pilar) Martin-Calvo, N. (Nerea) |
| author_sort | Arredondo-Montero, J. (Javier) |
| collection | DSpace |
| description | Congenital cytomegalovirus (CMV) infection can cause severe neurological sequelae or even fetal death. We present a 17-year-old pregnant woman with fetal CMV infection, leading to voluntary termination of pregnancy. Fetopsy demonstrated a brainstem hemorrhage and focal polymicrogyria. CMV inclusions were observed in the lung, liver, thyroid, pancreas, kidneys, adrenal, placenta, and central nervous system. Intracranial hemorrhage is a rare finding in the context of congenital CMV infection, with isolated brainstem hemorrhage being an exceptional form of presentation. Polymicrogyria appears to be a more frequent finding, although its actual incidence is unknown. Future studies are needed to determine the causal association. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-68174 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2023 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-681742023-12-25T06:04:31Z Congenital cytomegalovirus infection with brainstem hemorrhage and polymicrogyria: Necropsic and histopathological findings Arredondo-Montero, J. (Javier) Bronte-Anaut, M. (Mónica) Caballero, M.C. (M.C.) Fernández-Seara, M.P. (María del Pilar) Martin-Calvo, N. (Nerea) Congenital Cytomegalovirus Infection Intracranial hemorrhage Polymicrogyria Congenital cytomegalovirus (CMV) infection can cause severe neurological sequelae or even fetal death. We present a 17-year-old pregnant woman with fetal CMV infection, leading to voluntary termination of pregnancy. Fetopsy demonstrated a brainstem hemorrhage and focal polymicrogyria. CMV inclusions were observed in the lung, liver, thyroid, pancreas, kidneys, adrenal, placenta, and central nervous system. Intracranial hemorrhage is a rare finding in the context of congenital CMV infection, with isolated brainstem hemorrhage being an exceptional form of presentation. Polymicrogyria appears to be a more frequent finding, although its actual incidence is unknown. Future studies are needed to determine the causal association. 2023-12-22T10:30:33Z 2023-12-22T10:30:33Z 2022 info:eu-repo/semantics/article https://hdl.handle.net/10171/68174 eng info:eu-repo/semantics/openAccess application/pdf Wiley |
| spellingShingle | Congenital Cytomegalovirus Infection Intracranial hemorrhage Polymicrogyria Arredondo-Montero, J. (Javier) Bronte-Anaut, M. (Mónica) Caballero, M.C. (M.C.) Fernández-Seara, M.P. (María del Pilar) Martin-Calvo, N. (Nerea) Congenital cytomegalovirus infection with brainstem hemorrhage and polymicrogyria: Necropsic and histopathological findings |
| title | Congenital cytomegalovirus infection with brainstem hemorrhage and polymicrogyria: Necropsic and histopathological findings |
| title_full | Congenital cytomegalovirus infection with brainstem hemorrhage and polymicrogyria: Necropsic and histopathological findings |
| title_fullStr | Congenital cytomegalovirus infection with brainstem hemorrhage and polymicrogyria: Necropsic and histopathological findings |
| title_full_unstemmed | Congenital cytomegalovirus infection with brainstem hemorrhage and polymicrogyria: Necropsic and histopathological findings |
| title_short | Congenital cytomegalovirus infection with brainstem hemorrhage and polymicrogyria: Necropsic and histopathological findings |
| title_sort | congenital cytomegalovirus infection with brainstem hemorrhage and polymicrogyria: necropsic and histopathological findings |
| topic | Congenital Cytomegalovirus Infection Intracranial hemorrhage Polymicrogyria |
| url | https://hdl.handle.net/10171/68174 |
| work_keys_str_mv | AT arredondomonterojjavier congenitalcytomegalovirusinfectionwithbrainstemhemorrhageandpolymicrogyrianecropsicandhistopathologicalfindings AT bronteanautmmonica congenitalcytomegalovirusinfectionwithbrainstemhemorrhageandpolymicrogyrianecropsicandhistopathologicalfindings AT caballeromcmc congenitalcytomegalovirusinfectionwithbrainstemhemorrhageandpolymicrogyrianecropsicandhistopathologicalfindings AT fernandezsearampmariadelpilar congenitalcytomegalovirusinfectionwithbrainstemhemorrhageandpolymicrogyrianecropsicandhistopathologicalfindings AT martincalvonnerea congenitalcytomegalovirusinfectionwithbrainstemhemorrhageandpolymicrogyrianecropsicandhistopathologicalfindings |