Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus: A randomized trial
Background & aims: Short telomeres have been observed in chronic disease patients. Identifying envi- ronmental and lifestyle factors that could reduce telomere attrition is crucial for disease prevention. The aim of this work was to determine whether weight-loss induced by an energy-reduced Me...
| Main Authors: | , , , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Elsevier
2024
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| Online Access: | https://hdl.handle.net/10171/68505 |
| _version_ | 1793400118921134080 |
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| author | Marti-del-Moral, A. (Amelia) Fernández-de-la-Puente, M. (María) Canudas, Silvia (S.) Zalba, G. (Guillermo) Razquin, C. (Cristina) Valle-Hita, C. (Cristina) Fito, M. (Montserrat) Martinez-Gonzalez, M.A. (Miguel Ángel) Garcia-Calzon, S. (Sonia) Salas-Salvado, J. (Jordi) |
| author_facet | Marti-del-Moral, A. (Amelia) Fernández-de-la-Puente, M. (María) Canudas, Silvia (S.) Zalba, G. (Guillermo) Razquin, C. (Cristina) Valle-Hita, C. (Cristina) Fito, M. (Montserrat) Martinez-Gonzalez, M.A. (Miguel Ángel) Garcia-Calzon, S. (Sonia) Salas-Salvado, J. (Jordi) |
| author_sort | Marti-del-Moral, A. (Amelia) |
| collection | DSpace |
| description | Background & aims: Short telomeres have been observed in chronic disease patients. Identifying envi-
ronmental and lifestyle factors that could reduce telomere attrition is crucial for disease prevention. The
aim of this work was to determine whether weight-loss induced by an energy-reduced Mediterranean
diet (erMedDiet) and physical activity (PA) could modify telomere length (TL).
Methods: In 317 randomized non-smoker participants (mean age, 65.8 ± 4.98 years) with metabolic
syndrome from two “Prevenci on con Dieta Mediterr anea-Plus” (PREDIMED-Plus) trial centers, we
evaluated MedDiet adherence, PA, anthropometric variables and TL at baseline and after a 3-year
intervention using an intensive lifestyle program (IG) with an erMedDiet and PA or an unrestricted
MedDiet without PA promotion (CG).
Results: Participants in the IG displayed greater 3-year weight reductions ( 3.7 ± 4 kg, P < 0.001)
compared to those in the CG. No differences in TL changes between groups were observed in the cohort
as a whole. However, an interaction was observed between the intervention group and sex for TL changes
(pinteraction ¼ 0.039). Women in the IG showed an increase in TL after 3-y (þ0.25 ± 0.9, relative units)
compared to women in the CG ( 0.07 ± 1.0) (p ANCOVA ¼ 0.036), whereas no differences between groups
were observed in men. Women in the IG had a lower risk of telomere shortening after the intervention
(OR ¼ 0.17, 95%CI: 0.05e0.64, p ¼ 0.008) compared to women in the CG.
Conclusions: A 3-year lifestyle intervention based on an erMedDiet and PA slowed telomere shortening
in women but not in men. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-68505 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2024 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-685052024-01-29T06:05:30Z Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus: A randomized trial Marti-del-Moral, A. (Amelia) Fernández-de-la-Puente, M. (María) Canudas, Silvia (S.) Zalba, G. (Guillermo) Razquin, C. (Cristina) Valle-Hita, C. (Cristina) Fito, M. (Montserrat) Martinez-Gonzalez, M.A. (Miguel Ángel) Garcia-Calzon, S. (Sonia) Salas-Salvado, J. (Jordi) Mediterranean diet Calorie restriction Telomere length Physical activity Randomized controlled trial Background & aims: Short telomeres have been observed in chronic disease patients. Identifying envi- ronmental and lifestyle factors that could reduce telomere attrition is crucial for disease prevention. The aim of this work was to determine whether weight-loss induced by an energy-reduced Mediterranean diet (erMedDiet) and physical activity (PA) could modify telomere length (TL). Methods: In 317 randomized non-smoker participants (mean age, 65.8 ± 4.98 years) with metabolic syndrome from two “Prevenci on con Dieta Mediterr anea-Plus” (PREDIMED-Plus) trial centers, we evaluated MedDiet adherence, PA, anthropometric variables and TL at baseline and after a 3-year intervention using an intensive lifestyle program (IG) with an erMedDiet and PA or an unrestricted MedDiet without PA promotion (CG). Results: Participants in the IG displayed greater 3-year weight reductions ( 3.7 ± 4 kg, P < 0.001) compared to those in the CG. No differences in TL changes between groups were observed in the cohort as a whole. However, an interaction was observed between the intervention group and sex for TL changes (pinteraction ¼ 0.039). Women in the IG showed an increase in TL after 3-y (þ0.25 ± 0.9, relative units) compared to women in the CG ( 0.07 ± 1.0) (p ANCOVA ¼ 0.036), whereas no differences between groups were observed in men. Women in the IG had a lower risk of telomere shortening after the intervention (OR ¼ 0.17, 95%CI: 0.05e0.64, p ¼ 0.008) compared to women in the CG. Conclusions: A 3-year lifestyle intervention based on an erMedDiet and PA slowed telomere shortening in women but not in men. 2024-01-24T10:34:01Z 2024-01-24T10:34:01Z 2023 info:eu-repo/semantics/article https://hdl.handle.net/10171/68505 eng info:eu-repo/grantAgreement/MICINN/Centros de Investigación Biomédica en Red (CIBER)/ CB07/03/2004/ES/Obesidad y nutrición info:eu-repo/semantics/openAccess application/pdf Elsevier |
| spellingShingle | Mediterranean diet Calorie restriction Telomere length Physical activity Randomized controlled trial Marti-del-Moral, A. (Amelia) Fernández-de-la-Puente, M. (María) Canudas, Silvia (S.) Zalba, G. (Guillermo) Razquin, C. (Cristina) Valle-Hita, C. (Cristina) Fito, M. (Montserrat) Martinez-Gonzalez, M.A. (Miguel Ángel) Garcia-Calzon, S. (Sonia) Salas-Salvado, J. (Jordi) Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus: A randomized trial |
| title | Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus: A randomized trial |
| title_full | Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus: A randomized trial |
| title_fullStr | Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus: A randomized trial |
| title_full_unstemmed | Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus: A randomized trial |
| title_short | Effect of a 3-year lifestyle intervention on telomere length in participants from PREDIMED-Plus: A randomized trial |
| title_sort | effect of a 3-year lifestyle intervention on telomere length in participants from predimed-plus: a randomized trial |
| topic | Mediterranean diet Calorie restriction Telomere length Physical activity Randomized controlled trial |
| url | https://hdl.handle.net/10171/68505 |
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