Quality of Life in Patients with Allergic Reactions to Medications: Influence of a Drug Allergy Evaluation
Background Suspicion of allergic drug reaction can cause important disturbances in the patient's life. Objective We evaluated in a prospective multicenter study the quality of life of patients who suffered a possible allergic drug reaction, and analyzed the effect of a drug allergy evaluat...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
Elsevier
2024
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/68735 |
| _version_ | 1793400005192581120 |
|---|---|
| author | Gastaminza, G. (Gabriel) Ruiz-Canela, M. (Miguel) Andrés-López, B. (Blanca) Barasona-Villarejo, M.J (María J.) Cabañas. R. (Rosario) García-Núñez, I. (Ignacio) Goikoetxea-Lapresa, M.J. (María José) Laguna, J.J. (José Julio) Lobera, T. (Teófilo) López-San-Martín, M. (Marta) Martín-Lázaro, J. (Joaquín) |
| author_facet | Gastaminza, G. (Gabriel) Ruiz-Canela, M. (Miguel) Andrés-López, B. (Blanca) Barasona-Villarejo, M.J (María J.) Cabañas. R. (Rosario) García-Núñez, I. (Ignacio) Goikoetxea-Lapresa, M.J. (María José) Laguna, J.J. (José Julio) Lobera, T. (Teófilo) López-San-Martín, M. (Marta) Martín-Lázaro, J. (Joaquín) |
| author_sort | Gastaminza, G. (Gabriel) |
| collection | DSpace |
| description | Background
Suspicion of allergic drug reaction can cause important disturbances in the patient's life.
Objective
We evaluated in a prospective multicenter study the quality of life of patients who suffered a possible allergic drug reaction, and analyzed the effect of a drug allergy evaluation.
Methods
Patients (>18 years old) answered the specific questionnaire twice: before the drug allergy evaluation, and 1 month after it was completed. Statistics were performed using STATA.
Results
A total of 360 patients (240, 66.6% female; mean age, 45.4 years; standard deviation [SD], 15.6 years) completed the first questionnaire. After the evaluation, 150 of 346 patients (43.4%) were diagnosed as allergic to the drug (115 of 150 immediate; 35 of 150 delayed) and 196 of 346 patients (56.6%) as nonallergic. The mean value of the first questionnaire was 32.14 (SD, 11.84); patients with anaphylaxis, nonanaphylactic immediate reaction, with more than 1 drug reaction, or a chronic osteoarticular disease, had a statistically significant higher score in Q0 (worse quality of life). After the allergy study, the mean of the second questionnaire was 27.27 (SD, 9.96), showing a global improvement (P < .001). No statistically significant difference was found between drug allergic and non–drug allergic patients (P = .340); however, being >40 years old (P = .030), having a chronic osteoarticular disease (P = .003) and having more than 1 reaction to drugs (P < .001) were associated with a statistically significant worse quality of life after the evaluation.
Conclusions
Having suffered anaphylaxis, more than 1 reported drug allergy or presenting a musculoskeletal disease are factors that worsen the quality of life. Quality of life improved significantly after completing a drug allergy evaluation. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-68735 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2024 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-687352024-02-05T06:06:25Z Quality of Life in Patients with Allergic Reactions to Medications: Influence of a Drug Allergy Evaluation Gastaminza, G. (Gabriel) Ruiz-Canela, M. (Miguel) Andrés-López, B. (Blanca) Barasona-Villarejo, M.J (María J.) Cabañas. R. (Rosario) García-Núñez, I. (Ignacio) Goikoetxea-Lapresa, M.J. (María José) Laguna, J.J. (José Julio) Lobera, T. (Teófilo) López-San-Martín, M. (Marta) Martín-Lázaro, J. (Joaquín) Drug allergy Anaphylaxis Health-related quality of life Diagnosis Well-being Background Suspicion of allergic drug reaction can cause important disturbances in the patient's life. Objective We evaluated in a prospective multicenter study the quality of life of patients who suffered a possible allergic drug reaction, and analyzed the effect of a drug allergy evaluation. Methods Patients (>18 years old) answered the specific questionnaire twice: before the drug allergy evaluation, and 1 month after it was completed. Statistics were performed using STATA. Results A total of 360 patients (240, 66.6% female; mean age, 45.4 years; standard deviation [SD], 15.6 years) completed the first questionnaire. After the evaluation, 150 of 346 patients (43.4%) were diagnosed as allergic to the drug (115 of 150 immediate; 35 of 150 delayed) and 196 of 346 patients (56.6%) as nonallergic. The mean value of the first questionnaire was 32.14 (SD, 11.84); patients with anaphylaxis, nonanaphylactic immediate reaction, with more than 1 drug reaction, or a chronic osteoarticular disease, had a statistically significant higher score in Q0 (worse quality of life). After the allergy study, the mean of the second questionnaire was 27.27 (SD, 9.96), showing a global improvement (P < .001). No statistically significant difference was found between drug allergic and non–drug allergic patients (P = .340); however, being >40 years old (P = .030), having a chronic osteoarticular disease (P = .003) and having more than 1 reaction to drugs (P < .001) were associated with a statistically significant worse quality of life after the evaluation. Conclusions Having suffered anaphylaxis, more than 1 reported drug allergy or presenting a musculoskeletal disease are factors that worsen the quality of life. Quality of life improved significantly after completing a drug allergy evaluation. 2024-02-02T13:42:50Z 2024-02-02T13:42:50Z 2019 info:eu-repo/semantics/article https://hdl.handle.net/10171/68735 eng info:eu-repo/semantics/embargoedAccess application/pdf Elsevier |
| spellingShingle | Drug allergy Anaphylaxis Health-related quality of life Diagnosis Well-being Gastaminza, G. (Gabriel) Ruiz-Canela, M. (Miguel) Andrés-López, B. (Blanca) Barasona-Villarejo, M.J (María J.) Cabañas. R. (Rosario) García-Núñez, I. (Ignacio) Goikoetxea-Lapresa, M.J. (María José) Laguna, J.J. (José Julio) Lobera, T. (Teófilo) López-San-Martín, M. (Marta) Martín-Lázaro, J. (Joaquín) Quality of Life in Patients with Allergic Reactions to Medications: Influence of a Drug Allergy Evaluation |
| title | Quality of Life in Patients with Allergic Reactions to Medications: Influence of a Drug Allergy Evaluation |
| title_full | Quality of Life in Patients with Allergic Reactions to Medications: Influence of a Drug Allergy Evaluation |
| title_fullStr | Quality of Life in Patients with Allergic Reactions to Medications: Influence of a Drug Allergy Evaluation |
| title_full_unstemmed | Quality of Life in Patients with Allergic Reactions to Medications: Influence of a Drug Allergy Evaluation |
| title_short | Quality of Life in Patients with Allergic Reactions to Medications: Influence of a Drug Allergy Evaluation |
| title_sort | quality of life in patients with allergic reactions to medications: influence of a drug allergy evaluation |
| topic | Drug allergy Anaphylaxis Health-related quality of life Diagnosis Well-being |
| url | https://hdl.handle.net/10171/68735 |
| work_keys_str_mv | AT gastaminzaggabriel qualityoflifeinpatientswithallergicreactionstomedicationsinfluenceofadrugallergyevaluation AT ruizcanelammiguel qualityoflifeinpatientswithallergicreactionstomedicationsinfluenceofadrugallergyevaluation AT andreslopezbblanca qualityoflifeinpatientswithallergicreactionstomedicationsinfluenceofadrugallergyevaluation AT barasonavillarejomjmariaj qualityoflifeinpatientswithallergicreactionstomedicationsinfluenceofadrugallergyevaluation AT cabanasrrosario qualityoflifeinpatientswithallergicreactionstomedicationsinfluenceofadrugallergyevaluation AT garcianuneziignacio qualityoflifeinpatientswithallergicreactionstomedicationsinfluenceofadrugallergyevaluation AT goikoetxealapresamjmariajose qualityoflifeinpatientswithallergicreactionstomedicationsinfluenceofadrugallergyevaluation AT lagunajjjosejulio qualityoflifeinpatientswithallergicreactionstomedicationsinfluenceofadrugallergyevaluation AT loberatteofilo qualityoflifeinpatientswithallergicreactionstomedicationsinfluenceofadrugallergyevaluation AT lopezsanmartinmmarta qualityoflifeinpatientswithallergicreactionstomedicationsinfluenceofadrugallergyevaluation AT martinlazarojjoaquin qualityoflifeinpatientswithallergicreactionstomedicationsinfluenceofadrugallergyevaluation |