Chronic rhinosinusitis is associated with prolonged SARS-CoV-2 RNA shedding in upper respiratory tract samples: A case-control study
Abstract. Recalde-Zamacona B, Tomas-Vel azquez A, Campo A, Satrustegui-Alzugaray B, Fern andez- Alonso M, Inigo M, Rodr ~ ıguez-Mateos M, Di Frisco M, Felgueroso C, Berto J, Mar ın-Oto M, Alcaide AB, Zulueta JJ, Seijo L, Landecho MF (Clinica Universidad de Navarra; Health Center of San Ju...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
| Published: |
Ponte Editora, Sociedade Unipessoal, Lda.
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/68831 |
| _version_ | 1793400093786767360 |
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| author | Recalde-Zamacona, B. (Borja) Tomás-Velázquez, A. (Alejandra) Campo, A. (Aránzazu) Satrustegui-Alzugaray, B. (Blanca) Fernández-Alonso, M. (Miriam) Iñigo, M. (Melania) Rodríguez-Mateos, M. (Mariano) Madeleine-Di-Frisco, I. (I.) Felgueroso, C. (Carmen) Bertó, J. (Juan) Marín-Oto, M. (Marta) Alcaide, A.B. (Ana Belén) Zulueta, J. (Javier) Seijo, L. (Luis) Landecho, M.F. (Manuel F.) |
| author_facet | Recalde-Zamacona, B. (Borja) Tomás-Velázquez, A. (Alejandra) Campo, A. (Aránzazu) Satrustegui-Alzugaray, B. (Blanca) Fernández-Alonso, M. (Miriam) Iñigo, M. (Melania) Rodríguez-Mateos, M. (Mariano) Madeleine-Di-Frisco, I. (I.) Felgueroso, C. (Carmen) Bertó, J. (Juan) Marín-Oto, M. (Marta) Alcaide, A.B. (Ana Belén) Zulueta, J. (Javier) Seijo, L. (Luis) Landecho, M.F. (Manuel F.) |
| author_sort | Recalde-Zamacona, B. (Borja) |
| collection | DSpace |
| description | Abstract. Recalde-Zamacona B, Tomas-Vel azquez A,
Campo A, Satrustegui-Alzugaray B, Fern andez-
Alonso M, Inigo M, Rodr ~ ıguez-Mateos M, Di Frisco
M, Felgueroso C, Berto J, Mar ın-Oto M, Alcaide AB,
Zulueta JJ, Seijo L, Landecho MF (Clinica
Universidad de Navarra; Health Center of San
Juan, Pamplona, Spain). Chronic rhinosinusitis is
associated with prolonged SARS-CoV-2 RNA
shedding in upper respiratory tract samples: A
case-control study. J Intern Med 2021; 289: 921–
925. https://doi.org/10.1111/joim.13237
Background. SARS-CoV-2, the COVID-19 causative
agent, has infected millions of people and killed
over 1.6 million worldwide. A small percentage
of cases persist with prolonged positive RT-PCR
on nasopharyngeal swabs. The aim of this study
was to determine risk factors for prolonged viral
shedding amongst patient’s basal clinical
conditions.
Methods. We have evaluated all 513 patients
attended in our hospital between 1 March and 1
July. We have selected all 18 patients with pro-
longed viral shedding and compared them with 36
sex-matched randomly selected controls. Demo-
graphic, treatment and clinical data were system-
atically collected. Results. Global median duration of viral clearance was
25.5 days (n = 54; IQR, 22–39.3 days), 48.5 days in
cases (IQR 38.7–54.9 days) and 23 days in controls
(IQR 20.2–25.7), respectively. There were not
observed differences in demographic, symptoms or
treatment data between groups.Chronic rhinosi-
nusitis and atopy were more common in patients
with prolonged viral shedding (67%) compared with
controls (11% and 25% respectively) (P < 0.001 and
P = 0.003). The use of inhaled corticosteroids was
also more frequent in case group (P = 0.007). Mul-
tivariate analysis indicated that CRS (odds ratio
[OR], 18.78; 95% confidence interval [95%CI], 3.89–
90.59; P < 0.001) was independently associated
with prolonged SARS-CoV-2 RNA shedding in URT
samples, after adjusting for initial PCR Ct values.
Conclusion. We found that chronic rhinosinusitis and
atopy might be associated with increased risk of
prolonged viral shedding. If confirmed in prospec-
tive trials, this finding might have clinical implica-
tions for quarantine duration due to increased risk
of pandemic spread. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-68831 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2024 |
| publisher | Ponte Editora, Sociedade Unipessoal, Lda. |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-688312024-02-12T06:07:21Z Chronic rhinosinusitis is associated with prolonged SARS-CoV-2 RNA shedding in upper respiratory tract samples: A case-control study Recalde-Zamacona, B. (Borja) Tomás-Velázquez, A. (Alejandra) Campo, A. (Aránzazu) Satrustegui-Alzugaray, B. (Blanca) Fernández-Alonso, M. (Miriam) Iñigo, M. (Melania) Rodríguez-Mateos, M. (Mariano) Madeleine-Di-Frisco, I. (I.) Felgueroso, C. (Carmen) Bertó, J. (Juan) Marín-Oto, M. (Marta) Alcaide, A.B. (Ana Belén) Zulueta, J. (Javier) Seijo, L. (Luis) Landecho, M.F. (Manuel F.) Materias Investigacion::Ciencias de la Salud Chronic rhinosinusitis SARS-CoV-2 shedding Upper respiratory tract Atopy Inhaled corticosteroids Abstract. Recalde-Zamacona B, Tomas-Vel azquez A, Campo A, Satrustegui-Alzugaray B, Fern andez- Alonso M, Inigo M, Rodr ~ ıguez-Mateos M, Di Frisco M, Felgueroso C, Berto J, Mar ın-Oto M, Alcaide AB, Zulueta JJ, Seijo L, Landecho MF (Clinica Universidad de Navarra; Health Center of San Juan, Pamplona, Spain). Chronic rhinosinusitis is associated with prolonged SARS-CoV-2 RNA shedding in upper respiratory tract samples: A case-control study. J Intern Med 2021; 289: 921– 925. https://doi.org/10.1111/joim.13237 Background. SARS-CoV-2, the COVID-19 causative agent, has infected millions of people and killed over 1.6 million worldwide. A small percentage of cases persist with prolonged positive RT-PCR on nasopharyngeal swabs. The aim of this study was to determine risk factors for prolonged viral shedding amongst patient’s basal clinical conditions. Methods. We have evaluated all 513 patients attended in our hospital between 1 March and 1 July. We have selected all 18 patients with pro- longed viral shedding and compared them with 36 sex-matched randomly selected controls. Demo- graphic, treatment and clinical data were system- atically collected. Results. Global median duration of viral clearance was 25.5 days (n = 54; IQR, 22–39.3 days), 48.5 days in cases (IQR 38.7–54.9 days) and 23 days in controls (IQR 20.2–25.7), respectively. There were not observed differences in demographic, symptoms or treatment data between groups.Chronic rhinosi- nusitis and atopy were more common in patients with prolonged viral shedding (67%) compared with controls (11% and 25% respectively) (P < 0.001 and P = 0.003). The use of inhaled corticosteroids was also more frequent in case group (P = 0.007). Mul- tivariate analysis indicated that CRS (odds ratio [OR], 18.78; 95% confidence interval [95%CI], 3.89– 90.59; P < 0.001) was independently associated with prolonged SARS-CoV-2 RNA shedding in URT samples, after adjusting for initial PCR Ct values. Conclusion. We found that chronic rhinosinusitis and atopy might be associated with increased risk of prolonged viral shedding. If confirmed in prospec- tive trials, this finding might have clinical implica- tions for quarantine duration due to increased risk of pandemic spread. 2024-02-06T11:28:20Z 2024-02-06T11:28:20Z 2021 info:eu-repo/semantics/article https://hdl.handle.net/10171/68831 eng info:eu-repo/semantics/openAccess application/pdf Ponte Editora, Sociedade Unipessoal, Lda. |
| spellingShingle | Materias Investigacion::Ciencias de la Salud Chronic rhinosinusitis SARS-CoV-2 shedding Upper respiratory tract Atopy Inhaled corticosteroids Recalde-Zamacona, B. (Borja) Tomás-Velázquez, A. (Alejandra) Campo, A. (Aránzazu) Satrustegui-Alzugaray, B. (Blanca) Fernández-Alonso, M. (Miriam) Iñigo, M. (Melania) Rodríguez-Mateos, M. (Mariano) Madeleine-Di-Frisco, I. (I.) Felgueroso, C. (Carmen) Bertó, J. (Juan) Marín-Oto, M. (Marta) Alcaide, A.B. (Ana Belén) Zulueta, J. (Javier) Seijo, L. (Luis) Landecho, M.F. (Manuel F.) Chronic rhinosinusitis is associated with prolonged SARS-CoV-2 RNA shedding in upper respiratory tract samples: A case-control study |
| title | Chronic rhinosinusitis is associated with prolonged SARS-CoV-2 RNA shedding in upper respiratory tract samples: A case-control study |
| title_full | Chronic rhinosinusitis is associated with prolonged SARS-CoV-2 RNA shedding in upper respiratory tract samples: A case-control study |
| title_fullStr | Chronic rhinosinusitis is associated with prolonged SARS-CoV-2 RNA shedding in upper respiratory tract samples: A case-control study |
| title_full_unstemmed | Chronic rhinosinusitis is associated with prolonged SARS-CoV-2 RNA shedding in upper respiratory tract samples: A case-control study |
| title_short | Chronic rhinosinusitis is associated with prolonged SARS-CoV-2 RNA shedding in upper respiratory tract samples: A case-control study |
| title_sort | chronic rhinosinusitis is associated with prolonged sars-cov-2 rna shedding in upper respiratory tract samples: a case-control study |
| topic | Materias Investigacion::Ciencias de la Salud Chronic rhinosinusitis SARS-CoV-2 shedding Upper respiratory tract Atopy Inhaled corticosteroids |
| url | https://hdl.handle.net/10171/68831 |
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