Pneumococcal Serotypes Causing Acute Otitis Media Among Children in Barcelona (1992–2011): Emergence of the Multiresistant Clone ST320 of Serotype 19A
Background: There is scarce information about changes in serotypes and clonal types of Streptococcus pneumoniae causing acute otitis media (AOM) in recent years, particularly in European countries. Methods: Pneumococcal serotypes and clones from S. pneumoniae strains isolated from children with...
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Lippincott, Williams & Wilkins
2024
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| Online Access: | https://hdl.handle.net/10171/68949 |
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| author | Gene, A. (Amadeu) del-Amo, E. (Eva) Iñigo, M. (Melania) Monsonis, M. (Manuel) Pallares, R. (Roman) Muñoz-Almagro, C. (Carmen) |
| author_facet | Gene, A. (Amadeu) del-Amo, E. (Eva) Iñigo, M. (Melania) Monsonis, M. (Manuel) Pallares, R. (Roman) Muñoz-Almagro, C. (Carmen) |
| author_sort | Gene, A. (Amadeu) |
| collection | DSpace |
| description | Background: There is scarce information about changes in serotypes
and clonal types of Streptococcus pneumoniae causing acute otitis media
(AOM) in recent years, particularly in European countries.
Methods: Pneumococcal serotypes and clones from S. pneumoniae strains
isolated from children with AOM who were attended at Hospital Sant Joan
de Déu, Barcelona (1992 to 2011), were studied. Heptavalent pneumococ-
cal conjugate vaccine (PCV7) was introduced in June 2001. We defined 3
periods: prevaccine period 1992 to 2001, early vaccine period 2002 to 2006
and late vaccine period 2007 to 2011.
Results: There were 376 pneumococcal strains causing AOM, and 373
(99.2%) of them were serotyped. AOM caused by PCV7 serotypes declined
significantly: 161 of 245 (65.7%) episodes in 1992 to 2001 versus 22 of
67 (32.8%) in 2002 to 2006 versus 8 of 61 (13.1%) in 2007 to 2011 P <
0.001. In the last period (2007 to 2011), the potential serotype coverage for
the PCV10 was 16.4% and for the PCV13 was 68.9% (P < 0.001). Sero-
type 19A increased from 5.7% in 1992 to 2001 to 42.6% in 2007 to 2011
(P < 0.001). Among strains with penicillin minimal inhibitory concentra-
tion ≥0.12 μg/mL (n = 241), serotype 19A rose from 2.3% in the first period
to 57.9 % in the last period (P < 0.001). The clonal-type ST320 was initially
detected in 2005, and in the period 2007 to 2011, the ST320 was found in
72.7% of nonsusceptible serotype 19A isolates.
Conclusions: Among children with AOM, a rapid expansion of the mul-
tiresistant clone ST320 expressing serotype 19A has been observed in Bar-
celona. The implementation of PCV13, which includes this serotype, may
decrease the prevalence of AOM and reduce antimicrobial resistance. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-68949 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2024 |
| publisher | Lippincott, Williams & Wilkins |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-689492024-02-12T06:08:37Z Pneumococcal Serotypes Causing Acute Otitis Media Among Children in Barcelona (1992–2011): Emergence of the Multiresistant Clone ST320 of Serotype 19A Gene, A. (Amadeu) del-Amo, E. (Eva) Iñigo, M. (Melania) Monsonis, M. (Manuel) Pallares, R. (Roman) Muñoz-Almagro, C. (Carmen) Materias Investigacion::Ciencias de la Salud::Microbiología y biología molecular Otitis Streptococcus pneumoniae Multi locus sequence typing Serotypes Children Background: There is scarce information about changes in serotypes and clonal types of Streptococcus pneumoniae causing acute otitis media (AOM) in recent years, particularly in European countries. Methods: Pneumococcal serotypes and clones from S. pneumoniae strains isolated from children with AOM who were attended at Hospital Sant Joan de Déu, Barcelona (1992 to 2011), were studied. Heptavalent pneumococ- cal conjugate vaccine (PCV7) was introduced in June 2001. We defined 3 periods: prevaccine period 1992 to 2001, early vaccine period 2002 to 2006 and late vaccine period 2007 to 2011. Results: There were 376 pneumococcal strains causing AOM, and 373 (99.2%) of them were serotyped. AOM caused by PCV7 serotypes declined significantly: 161 of 245 (65.7%) episodes in 1992 to 2001 versus 22 of 67 (32.8%) in 2002 to 2006 versus 8 of 61 (13.1%) in 2007 to 2011 P < 0.001. In the last period (2007 to 2011), the potential serotype coverage for the PCV10 was 16.4% and for the PCV13 was 68.9% (P < 0.001). Sero- type 19A increased from 5.7% in 1992 to 2001 to 42.6% in 2007 to 2011 (P < 0.001). Among strains with penicillin minimal inhibitory concentra- tion ≥0.12 μg/mL (n = 241), serotype 19A rose from 2.3% in the first period to 57.9 % in the last period (P < 0.001). The clonal-type ST320 was initially detected in 2005, and in the period 2007 to 2011, the ST320 was found in 72.7% of nonsusceptible serotype 19A isolates. Conclusions: Among children with AOM, a rapid expansion of the mul- tiresistant clone ST320 expressing serotype 19A has been observed in Bar- celona. The implementation of PCV13, which includes this serotype, may decrease the prevalence of AOM and reduce antimicrobial resistance. 2024-02-09T08:32:35Z 2024-02-09T08:32:35Z 2013 info:eu-repo/semantics/article https://hdl.handle.net/10171/68949 eng info:eu-repo/semantics/closedAccess application/pdf Lippincott, Williams & Wilkins |
| spellingShingle | Materias Investigacion::Ciencias de la Salud::Microbiología y biología molecular Otitis Streptococcus pneumoniae Multi locus sequence typing Serotypes Children Gene, A. (Amadeu) del-Amo, E. (Eva) Iñigo, M. (Melania) Monsonis, M. (Manuel) Pallares, R. (Roman) Muñoz-Almagro, C. (Carmen) Pneumococcal Serotypes Causing Acute Otitis Media Among Children in Barcelona (1992–2011): Emergence of the Multiresistant Clone ST320 of Serotype 19A |
| title | Pneumococcal Serotypes Causing Acute Otitis Media Among Children in Barcelona (1992–2011): Emergence of the Multiresistant Clone ST320 of Serotype 19A |
| title_full | Pneumococcal Serotypes Causing Acute Otitis Media Among Children in Barcelona (1992–2011): Emergence of the Multiresistant Clone ST320 of Serotype 19A |
| title_fullStr | Pneumococcal Serotypes Causing Acute Otitis Media Among Children in Barcelona (1992–2011): Emergence of the Multiresistant Clone ST320 of Serotype 19A |
| title_full_unstemmed | Pneumococcal Serotypes Causing Acute Otitis Media Among Children in Barcelona (1992–2011): Emergence of the Multiresistant Clone ST320 of Serotype 19A |
| title_short | Pneumococcal Serotypes Causing Acute Otitis Media Among Children in Barcelona (1992–2011): Emergence of the Multiresistant Clone ST320 of Serotype 19A |
| title_sort | pneumococcal serotypes causing acute otitis media among children in barcelona (1992–2011): emergence of the multiresistant clone st320 of serotype 19a |
| topic | Materias Investigacion::Ciencias de la Salud::Microbiología y biología molecular Otitis Streptococcus pneumoniae Multi locus sequence typing Serotypes Children |
| url | https://hdl.handle.net/10171/68949 |
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