| Summary: | To evaluate the safety and efficacy of the surgical use of plasma rich in growth factors fibrin membrane (mPRGF) in different ocular
surface pathologies.
Fifteen patients with different corneal and conjunctival diseases were included in the study. Patients were grouped according to the
use of mPRGF as graft (corneal and/or conjunctival) or dressing; they were also grouped according to the surgical subgroup of
intervention (persistent corneal ulcer [PCU], keratoplasty, superficial keratectomy, corneal perforation, and pterygium). Best
corrected visual acuity, intraocular pressure (IOP), inflammation control time (ICT), mPRGF AT (PRGF membrane absorption time),
and the healing time of the epithelial defect (HTED) were evaluated throughout the clinical follow-up time. Safety assessment was also
performed reporting all adverse events.
mPRGF showed a total closure of the defect in 13 of 15 patients (86.7%) and a partial closure in 2 patients (13.3%). The mean
follow-up time was 11.1±4.2 (4.8–22.8) months, the mean ICT was 2.5±1.1 (1.0–4.0) months, the mean mPRGF AT was 12.4±2.0
(10.0–16.0) days, and for the global HTED the mean was 2.9±1.2 (1–4.8) months. Results showed an improvement in BCVA in all
patients, with an overall improvement of 2.9 in Vision Lines. The BCVA significantly improved (P<.05) in the groups of corneal graft
and dressing. In the PCU subgroup (6 patients), the healing time of epithelial defect was significantly reduced (P<.05) in patients
treated only with the mPRGF in comparison to those which mPRGF therapy was associated to the amniotic membrane. The IOP
remained stable (P>.05) throughout the clinical follow-up time. No adverse events were reported after mPRGF use.
The mPRGF is effective and safe as coadjuvant treatment in surgeries related with ocular surface disorders, being an alternative to
the use of amniotic membrane. The mPRGF accelerates tissue regeneration after ocular surface surgery thus minimizing
inflammation and fibrosis.
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