Towards inmunotherapeutic exploitation strategies of rotumor and antitumor cytokines
In the last two decades, cancer immunotherapy has become one of the most promising strategies for cancer treatment. Understanding the link between the immune responses and cancer was essential to the development of these novel therapies. In the late 1950’s, Burnet and Thomas suggested the role o...
| Main Authors: | , |
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| Format: | info:eu-repo/semantics/doctoralThesis |
| Language: | eng |
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Universidad de Navarra
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10171/69099 |
| _version_ | 1795386256823156736 |
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| author | Olivera, I. (Irene) Melero, I. (Ignacio) |
| author_facet | Olivera, I. (Irene) Melero, I. (Ignacio) |
| author_sort | Olivera, I. (Irene) |
| collection | DSpace |
| description | In the last two decades, cancer immunotherapy has become one of the most
promising strategies for cancer treatment. Understanding the link between the
immune responses and cancer was essential to the development of these novel
therapies.
In the late 1950’s, Burnet and Thomas suggested the role of the immune system in the
repression of carcinomas (1,2). In 2013, Chen and Mellman (3) published “the cancerImmunity cycle” that conceptually described the indispensable steps for an effective
antitumor response (figure 1). The cycle starts with the release of neoantigens by the
cancer cells which are captured by the dendritic cells (DCs) for processing. DCs migrate
to lymph nodes where they present processed antigens to T cells, activating effector T
cell responses. Finally, the activated T cells traffic to the tumor bed where they
specifically kill tumor cells which releases additional tumor antigens (3). If this cycle
works properly, the immune cells can eliminate or control the tumor. However, cancer
cells have developed different mechanisms to resist the immune system attack. |
| format | info:eu-repo/semantics/doctoralThesis |
| id | oai:dadun.unav.edu:10171-69099 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2024 |
| publisher | Universidad de Navarra |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-690992024-02-19T06:06:58Z Towards inmunotherapeutic exploitation strategies of rotumor and antitumor cytokines Olivera, I. (Irene) Melero, I. (Ignacio) Materias Investigacion::Ciencias de la Salud::Oncología Immunotherapeutic exploitation strategies Protumor cytokines Antitumor cytokines Cancer immunotherapy In the last two decades, cancer immunotherapy has become one of the most promising strategies for cancer treatment. Understanding the link between the immune responses and cancer was essential to the development of these novel therapies. In the late 1950’s, Burnet and Thomas suggested the role of the immune system in the repression of carcinomas (1,2). In 2013, Chen and Mellman (3) published “the cancerImmunity cycle” that conceptually described the indispensable steps for an effective antitumor response (figure 1). The cycle starts with the release of neoantigens by the cancer cells which are captured by the dendritic cells (DCs) for processing. DCs migrate to lymph nodes where they present processed antigens to T cells, activating effector T cell responses. Finally, the activated T cells traffic to the tumor bed where they specifically kill tumor cells which releases additional tumor antigens (3). If this cycle works properly, the immune cells can eliminate or control the tumor. However, cancer cells have developed different mechanisms to resist the immune system attack. 2024-02-13T14:01:54Z 2024-02-13T14:01:54Z 2024-02-13 2023-09-08 info:eu-repo/semantics/doctoralThesis https://hdl.handle.net/10171/69099 eng info:eu-repo/semantics/openAccess application/pdf Universidad de Navarra |
| spellingShingle | Materias Investigacion::Ciencias de la Salud::Oncología Immunotherapeutic exploitation strategies Protumor cytokines Antitumor cytokines Cancer immunotherapy Olivera, I. (Irene) Melero, I. (Ignacio) Towards inmunotherapeutic exploitation strategies of rotumor and antitumor cytokines |
| title | Towards inmunotherapeutic exploitation strategies of rotumor and antitumor cytokines |
| title_full | Towards inmunotherapeutic exploitation strategies of rotumor and antitumor cytokines |
| title_fullStr | Towards inmunotherapeutic exploitation strategies of rotumor and antitumor cytokines |
| title_full_unstemmed | Towards inmunotherapeutic exploitation strategies of rotumor and antitumor cytokines |
| title_short | Towards inmunotherapeutic exploitation strategies of rotumor and antitumor cytokines |
| title_sort | towards inmunotherapeutic exploitation strategies of rotumor and antitumor cytokines |
| topic | Materias Investigacion::Ciencias de la Salud::Oncología Immunotherapeutic exploitation strategies Protumor cytokines Antitumor cytokines Cancer immunotherapy |
| url | https://hdl.handle.net/10171/69099 |
| work_keys_str_mv | AT oliveraiirene towardsinmunotherapeuticexploitationstrategiesofrotumorandantitumorcytokines AT meleroiignacio towardsinmunotherapeuticexploitationstrategiesofrotumorandantitumorcytokines |