Pregestational BMI and higher offspring’s risk of overweight/obesity in smoker and non-smoker mothers
Objective: To assess the association between pregestational BMI and offspring's risk of overweight/obesity after accounting for the most important confounders, especially maternal smoking habit. Design: Prospective cohort study. Setting: The Seguimiento Universidad de Navarra (SUN) study...
| Main Authors: | , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | eng |
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Cambridge University Press
2024
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| Online Access: | https://hdl.handle.net/10171/69132 |
| _version_ | 1793400027948777472 |
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| author | Martin-Calvo, N. (Nerea) Santiago, S. (Susana) Segura, G. (Gloria) Fernández-Lázaro, C.I. (César I.) Barbería-Latasa, M. (María) Martinez-Gonzalez, M.A. (Miguel Ángel) |
| author_facet | Martin-Calvo, N. (Nerea) Santiago, S. (Susana) Segura, G. (Gloria) Fernández-Lázaro, C.I. (César I.) Barbería-Latasa, M. (María) Martinez-Gonzalez, M.A. (Miguel Ángel) |
| author_sort | Martin-Calvo, N. (Nerea) |
| collection | DSpace |
| description | Objective: To assess the association between pregestational BMI and offspring's risk of overweight/obesity after accounting for the most important confounders, especially maternal smoking habit.
Design: Prospective cohort study.
Setting: The Seguimiento Universidad de Navarra (SUN) study is a prospective cohort of Spanish graduates with more than 22 000 participants nationwide. Recruitment started in 1999, and it is permanently open. Data on diet, lifestyle and clinical diagnoses are collected at baseline and every 2 years.
Participants: Women from the SUN cohort who reported at least one pregnancy during follow-up (n 3496) were invited to this study. Among them, 1527 agreed to participate and completed an additional more detailed online questionnaire on their pregnancy history and their offspring's nutritional status.
Results: After excluding 165 children, we analysed data of 2791 participants born to 1485 mothers and observed that each 5 kg/m2 increase in pregestational BMI was associated with a 0·22 (95 % CI 0·15, 0·29) higher z-score in offspring's BMI and higher risk of overweight/obesity (multivariable-adjusted relative risk (RR) 1·57 (95 % CI 1·39, 1·77)) in childhood or adolescence. Furthermore, we observed stronger association in children born to smoker mothers (RR 1·91; 95 % CI 1·48, 2·46) than from non-smoker mothers (RR 1·51; 95 % CI 1·31, 1·73) (Pfor interaction = 0·02).
Conclusions: We found a synergistic interaction between pregestational BMI and maternal smoking habit on offspring's z-score of the BMI and in their risk of overweight/obesity. Although further research is needed to analyse dose-response relationships, these findings reinforce the importance of promoting healthy lifestyles in pregnant women in order to prevent childhood obesity. |
| format | info:eu-repo/semantics/article |
| id | oai:dadun.unav.edu:10171-69132 |
| institution | Universidad de Navarra |
| language | eng |
| publishDate | 2024 |
| publisher | Cambridge University Press |
| record_format | dspace |
| spelling | oai:dadun.unav.edu:10171-691322024-02-26T06:05:34Z Pregestational BMI and higher offspring’s risk of overweight/obesity in smoker and non-smoker mothers Martin-Calvo, N. (Nerea) Santiago, S. (Susana) Segura, G. (Gloria) Fernández-Lázaro, C.I. (César I.) Barbería-Latasa, M. (María) Martinez-Gonzalez, M.A. (Miguel Ángel) Childhood obesity Interaction Maternal BMI Smoking Objective: To assess the association between pregestational BMI and offspring's risk of overweight/obesity after accounting for the most important confounders, especially maternal smoking habit. Design: Prospective cohort study. Setting: The Seguimiento Universidad de Navarra (SUN) study is a prospective cohort of Spanish graduates with more than 22 000 participants nationwide. Recruitment started in 1999, and it is permanently open. Data on diet, lifestyle and clinical diagnoses are collected at baseline and every 2 years. Participants: Women from the SUN cohort who reported at least one pregnancy during follow-up (n 3496) were invited to this study. Among them, 1527 agreed to participate and completed an additional more detailed online questionnaire on their pregnancy history and their offspring's nutritional status. Results: After excluding 165 children, we analysed data of 2791 participants born to 1485 mothers and observed that each 5 kg/m2 increase in pregestational BMI was associated with a 0·22 (95 % CI 0·15, 0·29) higher z-score in offspring's BMI and higher risk of overweight/obesity (multivariable-adjusted relative risk (RR) 1·57 (95 % CI 1·39, 1·77)) in childhood or adolescence. Furthermore, we observed stronger association in children born to smoker mothers (RR 1·91; 95 % CI 1·48, 2·46) than from non-smoker mothers (RR 1·51; 95 % CI 1·31, 1·73) (Pfor interaction = 0·02). Conclusions: We found a synergistic interaction between pregestational BMI and maternal smoking habit on offspring's z-score of the BMI and in their risk of overweight/obesity. Although further research is needed to analyse dose-response relationships, these findings reinforce the importance of promoting healthy lifestyles in pregnant women in order to prevent childhood obesity. 2024-02-20T09:33:13Z 2024-02-20T09:33:13Z 2021 info:eu-repo/semantics/article https://hdl.handle.net/10171/69132 eng Info:eu-repo/grantAgreement/MINECO/Proyectos de investigación en salud (AE Salud 2014)/PI14/01764/[ES]/Prevención eficiente de la demencia en sujetos con alto riesgo Info:eu-repo/grantAgreement/ISCIII/Proyectos de investigación en salud/PI17/01795/[ES]/ESTUDIO DE LA OBESIDAD COMO FACTOR DE RIESGO DE MORTALIDAD Y SU PREVENCION MEDIANTE RECOMENDACIONES DIETETICAS: ANALISIS LONGITUDINAL DE LA COHORTE SUN info:eu-repo/semantics/openAccess application/pdf Cambridge University Press |
| spellingShingle | Childhood obesity Interaction Maternal BMI Smoking Martin-Calvo, N. (Nerea) Santiago, S. (Susana) Segura, G. (Gloria) Fernández-Lázaro, C.I. (César I.) Barbería-Latasa, M. (María) Martinez-Gonzalez, M.A. (Miguel Ángel) Pregestational BMI and higher offspring’s risk of overweight/obesity in smoker and non-smoker mothers |
| title | Pregestational BMI and higher offspring’s risk of overweight/obesity in smoker and non-smoker mothers |
| title_full | Pregestational BMI and higher offspring’s risk of overweight/obesity in smoker and non-smoker mothers |
| title_fullStr | Pregestational BMI and higher offspring’s risk of overweight/obesity in smoker and non-smoker mothers |
| title_full_unstemmed | Pregestational BMI and higher offspring’s risk of overweight/obesity in smoker and non-smoker mothers |
| title_short | Pregestational BMI and higher offspring’s risk of overweight/obesity in smoker and non-smoker mothers |
| title_sort | pregestational bmi and higher offspring’s risk of overweight/obesity in smoker and non-smoker mothers |
| topic | Childhood obesity Interaction Maternal BMI Smoking |
| url | https://hdl.handle.net/10171/69132 |
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