Adipokines in dental pulp: physiological, pathological and potential therapeutic roles
Background: Hundreds of adipokines have been identified, and their extensive range of endocrine functions—regulating distant organs such as oral tissues—and local autocrine/paracrine roles have been studied. In dentistry, however, adipokines are poorly known proteins in the dental pulp; few of...
| Main Authors: | , |
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| Other Authors: | |
| Format: | masterThesis |
| Language: | eng |
| Published: |
Universidad de Cuenca
2022
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| Subjects: | |
| Online Access: | http://dspace.ucuenca.edu.ec/handle/123456789/38051 |
| _version_ | 1785802384600989696 |
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| author | Gavidia Pazmiño, Jonathan Francisco Bravo Guapisaca, María Isabel |
| author2 | Intriago Morales, Ruth Viviana |
| author_facet | Intriago Morales, Ruth Viviana Gavidia Pazmiño, Jonathan Francisco Bravo Guapisaca, María Isabel |
| author_sort | Gavidia Pazmiño, Jonathan Francisco |
| collection | DSpace |
| description | Background: Hundreds of adipokines have been identified, and their extensive range of
endocrine functions—regulating distant organs such as oral tissues—and local
autocrine/paracrine roles have been studied. In dentistry, however, adipokines are poorly
known proteins in the dental pulp; few of them have been studied despite their large
number. This study reviews recent advances in the investigation of dental-pulp
adipokines, with an emphasis on their roles in inflammatory processes and their potential
therapeutic applications.
Highlights: The most recently identified adipokines in dental pulp include leptin,
adiponectin, resistin, ghrelin, oncostatin, chemerin, and visfatin. They have numerous
physiological and pathological functions in the pulp tissue: they are closely related to pulp
inflammatory mechanisms and actively participate in cell differentiation, mineralization,
angiogenesis, and immune-system modulation.
Conclusion: Adipokines have potential clinical applications in regenerative endodontics
and as biomarkers or targets for the pharmacological management of inflammatory and
degenerative processes in dental pulp. A promising direction for the development of new
therapies may be the use of agonists/antagonists to modulate the expression of the most
studied adipokines. |
| format | masterThesis |
| id | oai:dspace.ucuenca.edu.ec:123456789-38051 |
| institution | Universidad de Cuenca |
| language | eng |
| publishDate | 2022 |
| publisher | Universidad de Cuenca |
| record_format | dspace |
| spelling | oai:dspace.ucuenca.edu.ec:123456789-380512022-02-21T09:00:18Z Adipokines in dental pulp: physiological, pathological and potential therapeutic roles Gavidia Pazmiño, Jonathan Francisco Bravo Guapisaca, María Isabel Intriago Morales, Ruth Viviana Odontología Patología oral Endodoncia Background: Hundreds of adipokines have been identified, and their extensive range of endocrine functions—regulating distant organs such as oral tissues—and local autocrine/paracrine roles have been studied. In dentistry, however, adipokines are poorly known proteins in the dental pulp; few of them have been studied despite their large number. This study reviews recent advances in the investigation of dental-pulp adipokines, with an emphasis on their roles in inflammatory processes and their potential therapeutic applications. Highlights: The most recently identified adipokines in dental pulp include leptin, adiponectin, resistin, ghrelin, oncostatin, chemerin, and visfatin. They have numerous physiological and pathological functions in the pulp tissue: they are closely related to pulp inflammatory mechanisms and actively participate in cell differentiation, mineralization, angiogenesis, and immune-system modulation. Conclusion: Adipokines have potential clinical applications in regenerative endodontics and as biomarkers or targets for the pharmacological management of inflammatory and degenerative processes in dental pulp. A promising direction for the development of new therapies may be the use of agonists/antagonists to modulate the expression of the most studied adipokines. Especialista en Endodoncia Cuenca 2022-02-14T14:40:24Z 2022-02-14T14:40:24Z 2022-02-11 masterThesis Artículo científico http://dspace.ucuenca.edu.ec/handle/123456789/38051 eng ODONEN;017 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ openAccess application/pdf 48 páginas application/pdf Universidad de Cuenca |
| spellingShingle | Odontología Patología oral Endodoncia Gavidia Pazmiño, Jonathan Francisco Bravo Guapisaca, María Isabel Adipokines in dental pulp: physiological, pathological and potential therapeutic roles |
| title | Adipokines in dental pulp: physiological, pathological and potential therapeutic roles |
| title_full | Adipokines in dental pulp: physiological, pathological and potential therapeutic roles |
| title_fullStr | Adipokines in dental pulp: physiological, pathological and potential therapeutic roles |
| title_full_unstemmed | Adipokines in dental pulp: physiological, pathological and potential therapeutic roles |
| title_short | Adipokines in dental pulp: physiological, pathological and potential therapeutic roles |
| title_sort | adipokines in dental pulp: physiological, pathological and potential therapeutic roles |
| topic | Odontología Patología oral Endodoncia |
| url | http://dspace.ucuenca.edu.ec/handle/123456789/38051 |
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