Dental pulp fibroblast: a star cell
Introduction Dental pulp fibroblasts (DPF) are the most abundant cell type in the dental pulp. They play pivotal roles; however, they are often mistaken to be involved only in the repair and maintenance of this connective tissue. Methods We used the search terms “pulp fibroblast,” “complement s...
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| Other Authors: | |
| Format: | masterThesis |
| Language: | spa |
| Published: |
Universidad de Cuenca
2022
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| Online Access: | http://dspace.ucuenca.edu.ec/handle/123456789/39897 |
| _version_ | 1785802375200505856 |
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| author | Castañeda Alvarado, Cristina Paola |
| author2 | Álvarez Vásquez, José Luis |
| author_facet | Álvarez Vásquez, José Luis Castañeda Alvarado, Cristina Paola |
| author_sort | Castañeda Alvarado, Cristina Paola |
| collection | DSpace |
| description | Introduction
Dental pulp fibroblasts (DPF) are the most abundant cell type in the dental pulp.
They play pivotal roles; however, they are often mistaken to be involved only in the
repair and maintenance of this connective tissue.
Methods
We used the search terms “pulp fibroblast,” “complement system proteins,” “pulp
inflammation,” “angiogenesis,” and “dentin pulp regeneration” to identify articles from
the PubMed and Scopus databases
Results
These sentinel cells produce all complement system proteins participating in defense
processes, control of inflammation, and dentin-pulp regeneration; produce several
proinflammatory cytokines and chemokines and express patternrecognition
receptors, demonstrating their involvement in immunoregulatory mechanisms;
express neuropeptides and their receptors, playing an important role in neurogenic
inflammation and dental pulp wound healing; secrete angiogenic growth factors as
well as neurotrophic proteins, essential for dentin-pulp regeneration; regulate
neuronal plasticity processes; and can sense the external environment.
Conclusion
This review highlights that DPFs are more than mere passive cells in pulp biology
and presents an integrative analysis of their roles and functions. |
| format | masterThesis |
| id | oai:dspace.ucuenca.edu.ec:123456789-39897 |
| institution | Universidad de Cuenca |
| language | spa |
| publishDate | 2022 |
| publisher | Universidad de Cuenca |
| record_format | dspace |
| spelling | oai:dspace.ucuenca.edu.ec:123456789-398972022-09-26T09:00:20Z Dental pulp fibroblast: a star cell Castañeda Alvarado, Cristina Paola Álvarez Vásquez, José Luis Odontología Endodoncia Pulpa dental Fibroblastos Endodoncia regenerativa Sistema estomatognático Introduction Dental pulp fibroblasts (DPF) are the most abundant cell type in the dental pulp. They play pivotal roles; however, they are often mistaken to be involved only in the repair and maintenance of this connective tissue. Methods We used the search terms “pulp fibroblast,” “complement system proteins,” “pulp inflammation,” “angiogenesis,” and “dentin pulp regeneration” to identify articles from the PubMed and Scopus databases Results These sentinel cells produce all complement system proteins participating in defense processes, control of inflammation, and dentin-pulp regeneration; produce several proinflammatory cytokines and chemokines and express patternrecognition receptors, demonstrating their involvement in immunoregulatory mechanisms; express neuropeptides and their receptors, playing an important role in neurogenic inflammation and dental pulp wound healing; secrete angiogenic growth factors as well as neurotrophic proteins, essential for dentin-pulp regeneration; regulate neuronal plasticity processes; and can sense the external environment. Conclusion This review highlights that DPFs are more than mere passive cells in pulp biology and presents an integrative analysis of their roles and functions. Especialista en Endodoncia Cuenca 2022-09-19T21:35:38Z 2022-09-19T21:35:38Z 2022-09-19 masterThesis Artículo Académico http://dspace.ucuenca.edu.ec/handle/123456789/39897 spa ODONEN;020 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ openAccess application/pdf 40 páginas application/pdf Universidad de Cuenca |
| spellingShingle | Odontología Endodoncia Pulpa dental Fibroblastos Endodoncia regenerativa Sistema estomatognático Castañeda Alvarado, Cristina Paola Dental pulp fibroblast: a star cell |
| title | Dental pulp fibroblast: a star cell |
| title_full | Dental pulp fibroblast: a star cell |
| title_fullStr | Dental pulp fibroblast: a star cell |
| title_full_unstemmed | Dental pulp fibroblast: a star cell |
| title_short | Dental pulp fibroblast: a star cell |
| title_sort | dental pulp fibroblast: a star cell |
| topic | Odontología Endodoncia Pulpa dental Fibroblastos Endodoncia regenerativa Sistema estomatognático |
| url | http://dspace.ucuenca.edu.ec/handle/123456789/39897 |
| work_keys_str_mv | AT castanedaalvaradocristinapaola dentalpulpfibroblastastarcell |