L-Citrulline: A Non-Essential Amino Acid with Important Roles in Human Health
L-Arginine (Arg) has been widely used due to its functional properties as a substrate for nitric oxide (NO) generation. However, L-citrulline (CIT), whose main natural source is watermelon, is a non-essential amino acid but which has important health potential. This review provides a comprehensive a...
| প্রধান লেখক: | , , , |
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| বিন্যাস: | info:eu-repo/semantics/article |
| ভাষা: | English |
| প্রকাশিত: |
MDPI
2021
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | http://hdl.handle.net/10835/10497 |
| _version_ | 1789406332940451840 |
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| author | Aguayo, Encarna Martínez-Sánchez, Ascensión Fernández-Lobato, Bárbara Alacid Cárceles, Fernando |
| author_facet | Aguayo, Encarna Martínez-Sánchez, Ascensión Fernández-Lobato, Bárbara Alacid Cárceles, Fernando |
| author_sort | Aguayo, Encarna |
| collection | DSpace |
| description | L-Arginine (Arg) has been widely used due to its functional properties as a substrate for nitric oxide (NO) generation. However, L-citrulline (CIT), whose main natural source is watermelon, is a non-essential amino acid but which has important health potential. This review provides a comprehensive approach to different studies of the endogenous synthesis of CIT, metabolism, pharmacokinetics, and pharmacodynamics as well as its ergogenic effect in exercise performance. The novel aspect of this paper focuses on the different effects of CIT, citrulline malate and CIT from natural sources such as watermelon on several topics, including cardiovascular diseases, diabetes, erectile dysfunction, cancer, and exercise performance. CIT from watermelon could be a natural food-sourced substitute for pharmacological products and therefore the consumption of this fruit is promoted. |
| format | info:eu-repo/semantics/article |
| id | oai:repositorio.ual.es:10835-10497 |
| institution | Universidad de Cuenca |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oai:repositorio.ual.es:10835-104972023-10-11T08:53:40Z L-Citrulline: A Non-Essential Amino Acid with Important Roles in Human Health Aguayo, Encarna Martínez-Sánchez, Ascensión Fernández-Lobato, Bárbara Alacid Cárceles, Fernando functional food bio-active compounds sport performance phytochemicals watermelon muscle fatigue ergogenic aids L-Arginine (Arg) has been widely used due to its functional properties as a substrate for nitric oxide (NO) generation. However, L-citrulline (CIT), whose main natural source is watermelon, is a non-essential amino acid but which has important health potential. This review provides a comprehensive approach to different studies of the endogenous synthesis of CIT, metabolism, pharmacokinetics, and pharmacodynamics as well as its ergogenic effect in exercise performance. The novel aspect of this paper focuses on the different effects of CIT, citrulline malate and CIT from natural sources such as watermelon on several topics, including cardiovascular diseases, diabetes, erectile dysfunction, cancer, and exercise performance. CIT from watermelon could be a natural food-sourced substitute for pharmacological products and therefore the consumption of this fruit is promoted. 2021-04-19T09:11:56Z 2021-04-19T09:11:56Z 2021-04-06 info:eu-repo/semantics/article 2076-3417 http://hdl.handle.net/10835/10497 en https://www.mdpi.com/2076-3417/11/7/3293 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess MDPI |
| spellingShingle | functional food bio-active compounds sport performance phytochemicals watermelon muscle fatigue ergogenic aids Aguayo, Encarna Martínez-Sánchez, Ascensión Fernández-Lobato, Bárbara Alacid Cárceles, Fernando L-Citrulline: A Non-Essential Amino Acid with Important Roles in Human Health |
| title | L-Citrulline: A Non-Essential Amino Acid with Important Roles in Human Health |
| title_full | L-Citrulline: A Non-Essential Amino Acid with Important Roles in Human Health |
| title_fullStr | L-Citrulline: A Non-Essential Amino Acid with Important Roles in Human Health |
| title_full_unstemmed | L-Citrulline: A Non-Essential Amino Acid with Important Roles in Human Health |
| title_short | L-Citrulline: A Non-Essential Amino Acid with Important Roles in Human Health |
| title_sort | l-citrulline: a non-essential amino acid with important roles in human health |
| topic | functional food bio-active compounds sport performance phytochemicals watermelon muscle fatigue ergogenic aids |
| url | http://hdl.handle.net/10835/10497 |
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