Increased Compulsivity in Adulthood after Early Adolescence Immune Activation: Preclinical Evidence
Immune activation during early developmental stages has been proposed as a contributing factor in the pathogenesis of neuropsychiatric conditions such as obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, and autism in both human and animal studies. However, its relationship wi...
| Main Authors: | , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
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MDPI
2021
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| Online Access: | http://hdl.handle.net/10835/10622 https://doi.org/10.3390/ijerph18094684 |
| _version_ | 1789406290593710080 |
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| author | Mora Parada, Santiago Martín González, Elena Prados Pardo, Ángeles Flores Cubos, Pilar Moreno Montoya, Margarita |
| author_facet | Mora Parada, Santiago Martín González, Elena Prados Pardo, Ángeles Flores Cubos, Pilar Moreno Montoya, Margarita |
| author_sort | Mora Parada, Santiago |
| collection | DSpace |
| description | Immune activation during early developmental stages has been proposed as a contributing factor in the pathogenesis of neuropsychiatric conditions such as obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, and autism in both human and animal studies. However, its relationship with the vulnerability to inhibitory control deficit, which is a shared feature among those conditions, remains unclear. The present work studied whether postnatal immune activation during early adolescence, combined with exposure to early-life adverse events, could lead to adult vulnerability to impulsive and/or compulsive behaviors. Male Wistar rats were exposed to lipopolysaccharide (LPS) in early adolescence at postnatal day 26 (PND26). During peripuberal period, half of the animals were exposed to a mild stress protocol. In adulthood, behavioral assessment was performed with the aid of the sustained attentional 5-choice serial reaction time (5-CSRT) task, schedule-induced polydipsia (SIP), and open-field locomotor activity and novelty reactivity. Rats exposed to LPS showed more compulsive responses than their control counterparts on 5-CSRT task, although no differences were observed in SIP or locomotor responses. Our study contributes to the knowledge of the relationship between immune activation and inhibitory control deficit. Future studies should aim to disentangle how, and to what extent, immune activation impacts behavior, and to understand the role of early life mild stress. |
| format | info:eu-repo/semantics/article |
| id | oai:repositorio.ual.es:10835-10622 |
| institution | Universidad de Cuenca |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oai:repositorio.ual.es:10835-106222023-04-12T19:41:03Z Increased Compulsivity in Adulthood after Early Adolescence Immune Activation: Preclinical Evidence Mora Parada, Santiago Martín González, Elena Prados Pardo, Ángeles Flores Cubos, Pilar Moreno Montoya, Margarita inhibitory control compulsivity immune activation behavior preclinical models early life adversity Immune activation during early developmental stages has been proposed as a contributing factor in the pathogenesis of neuropsychiatric conditions such as obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, and autism in both human and animal studies. However, its relationship with the vulnerability to inhibitory control deficit, which is a shared feature among those conditions, remains unclear. The present work studied whether postnatal immune activation during early adolescence, combined with exposure to early-life adverse events, could lead to adult vulnerability to impulsive and/or compulsive behaviors. Male Wistar rats were exposed to lipopolysaccharide (LPS) in early adolescence at postnatal day 26 (PND26). During peripuberal period, half of the animals were exposed to a mild stress protocol. In adulthood, behavioral assessment was performed with the aid of the sustained attentional 5-choice serial reaction time (5-CSRT) task, schedule-induced polydipsia (SIP), and open-field locomotor activity and novelty reactivity. Rats exposed to LPS showed more compulsive responses than their control counterparts on 5-CSRT task, although no differences were observed in SIP or locomotor responses. Our study contributes to the knowledge of the relationship between immune activation and inhibitory control deficit. Future studies should aim to disentangle how, and to what extent, immune activation impacts behavior, and to understand the role of early life mild stress. 2021-05-03T08:40:40Z 2021-05-03T08:40:40Z 2021-04-28 info:eu-repo/semantics/article 1660-4601 http://hdl.handle.net/10835/10622 https://doi.org/10.3390/ijerph18094684 en https://www.mdpi.com/1660-4601/18/9/4684 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess MDPI |
| spellingShingle | inhibitory control compulsivity immune activation behavior preclinical models early life adversity Mora Parada, Santiago Martín González, Elena Prados Pardo, Ángeles Flores Cubos, Pilar Moreno Montoya, Margarita Increased Compulsivity in Adulthood after Early Adolescence Immune Activation: Preclinical Evidence |
| title | Increased Compulsivity in Adulthood after Early Adolescence Immune Activation: Preclinical Evidence |
| title_full | Increased Compulsivity in Adulthood after Early Adolescence Immune Activation: Preclinical Evidence |
| title_fullStr | Increased Compulsivity in Adulthood after Early Adolescence Immune Activation: Preclinical Evidence |
| title_full_unstemmed | Increased Compulsivity in Adulthood after Early Adolescence Immune Activation: Preclinical Evidence |
| title_short | Increased Compulsivity in Adulthood after Early Adolescence Immune Activation: Preclinical Evidence |
| title_sort | increased compulsivity in adulthood after early adolescence immune activation: preclinical evidence |
| topic | inhibitory control compulsivity immune activation behavior preclinical models early life adversity |
| url | http://hdl.handle.net/10835/10622 https://doi.org/10.3390/ijerph18094684 |
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