Assessment of the Risk of Antipsychotics in Patients with Dementia in Actual Clinical Practice in Primary Health Care
Behavioral and psychological symptoms are almost universal in elderly patients with dementia. Antipsychotic drugs can be used but only in specific contexts as they can generate severe adverse effects. The main aim of this research was to evaluate the use of antipsychotic drugs in patients with accom...
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
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MDPI
2021
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| Online Access: | http://hdl.handle.net/10835/12368 https://doi.org/10.3390/ph14100997 |
| _version_ | 1789408404260782080 |
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| author | González López, María del Carmen García Ramón, María José Nievas-Soriano, Bruno José Parrón Carreño, Tesifón |
| author_facet | González López, María del Carmen García Ramón, María José Nievas-Soriano, Bruno José Parrón Carreño, Tesifón |
| author_sort | González López, María del Carmen |
| collection | DSpace |
| description | Behavioral and psychological symptoms are almost universal in elderly patients with dementia. Antipsychotic drugs can be used but only in specific contexts as they can generate severe adverse effects. The main aim of this research was to evaluate the use of antipsychotic drugs in patients with accompanying treatment for dementia in actual clinical practice in primary health care. We further sought to analyze risk variables and factors associated and to acknowledge how sociodemographic and clinical factors weighed on adverse effects’ occurrence. A multicentric cross-sectional descriptive study was performed in three provinces of Spain. Stratified random sampling was performed to select 332 patients. Clinical data from their digital medical records were collected by their family doctors. The Global risk defined if the patients were subjected to risk. Univariate, bivariate, and multivariate analyses were performed. The most used antipsychotics were quetiapine (65.5%), haloperidol (21.75%), and risperidone (15.8%); 93.8% of patients showed risk, and 81.1% of doses and 75.5% of treatment durations were inappropriate. These two last factors increased the global risk 23 and 20 times, respectively. Conclusions: In actual clinical practice conditions, a high use of antipsychotic drugs was found in patients with dementia. Most patients had inappropriate doses and treatment duration, factors that increased the risk of adverse effects considerably. |
| format | info:eu-repo/semantics/article |
| id | oai:repositorio.ual.es:10835-12368 |
| institution | Universidad de Cuenca |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oai:repositorio.ual.es:10835-123682023-04-12T19:20:21Z Assessment of the Risk of Antipsychotics in Patients with Dementia in Actual Clinical Practice in Primary Health Care González López, María del Carmen García Ramón, María José Nievas-Soriano, Bruno José Parrón Carreño, Tesifón antipsychotic dementia elderl primary health care actual clinical practice Behavioral and psychological symptoms are almost universal in elderly patients with dementia. Antipsychotic drugs can be used but only in specific contexts as they can generate severe adverse effects. The main aim of this research was to evaluate the use of antipsychotic drugs in patients with accompanying treatment for dementia in actual clinical practice in primary health care. We further sought to analyze risk variables and factors associated and to acknowledge how sociodemographic and clinical factors weighed on adverse effects’ occurrence. A multicentric cross-sectional descriptive study was performed in three provinces of Spain. Stratified random sampling was performed to select 332 patients. Clinical data from their digital medical records were collected by their family doctors. The Global risk defined if the patients were subjected to risk. Univariate, bivariate, and multivariate analyses were performed. The most used antipsychotics were quetiapine (65.5%), haloperidol (21.75%), and risperidone (15.8%); 93.8% of patients showed risk, and 81.1% of doses and 75.5% of treatment durations were inappropriate. These two last factors increased the global risk 23 and 20 times, respectively. Conclusions: In actual clinical practice conditions, a high use of antipsychotic drugs was found in patients with dementia. Most patients had inappropriate doses and treatment duration, factors that increased the risk of adverse effects considerably. 2021-10-04T10:50:14Z 2021-10-04T10:50:14Z 2021-09-29 info:eu-repo/semantics/article 1424-8247 http://hdl.handle.net/10835/12368 https://doi.org/10.3390/ph14100997 en https://www.mdpi.com/1424-8247/14/10/997 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess MDPI |
| spellingShingle | antipsychotic dementia elderl primary health care actual clinical practice González López, María del Carmen García Ramón, María José Nievas-Soriano, Bruno José Parrón Carreño, Tesifón Assessment of the Risk of Antipsychotics in Patients with Dementia in Actual Clinical Practice in Primary Health Care |
| title | Assessment of the Risk of Antipsychotics in Patients with Dementia in Actual Clinical Practice in Primary Health Care |
| title_full | Assessment of the Risk of Antipsychotics in Patients with Dementia in Actual Clinical Practice in Primary Health Care |
| title_fullStr | Assessment of the Risk of Antipsychotics in Patients with Dementia in Actual Clinical Practice in Primary Health Care |
| title_full_unstemmed | Assessment of the Risk of Antipsychotics in Patients with Dementia in Actual Clinical Practice in Primary Health Care |
| title_short | Assessment of the Risk of Antipsychotics in Patients with Dementia in Actual Clinical Practice in Primary Health Care |
| title_sort | assessment of the risk of antipsychotics in patients with dementia in actual clinical practice in primary health care |
| topic | antipsychotic dementia elderl primary health care actual clinical practice |
| url | http://hdl.handle.net/10835/12368 https://doi.org/10.3390/ph14100997 |
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