A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial, Evaluating the Effect of Supplementation with a Spinach Extract on Skeletal Muscle Fitness in Adults Older Than 50 Years of Age
The aim of a 12-week randomized double-blind placebo-controlled study was to assess the effect of daily supplementation with a natural extract of Spinacia oleracea L. (4 × 500 mg capsules/day; total 2 g per day) combined with a moderate-intensity training program (1 h session/3 times a week) on skel...
| Main Authors: | , , , , , |
|---|---|
| Format: | info:eu-repo/semantics/article |
| Language: | English |
| Published: |
MDPI
2021
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10835/13106 |
| _version_ | 1789406485795569664 |
|---|---|
| author | Pérez-Piñero, Silvia Ávila-Gandía, Vicente Rubio Arias, Jacobo Ángel Muñoz-Carrillo, Juan Carlos Losada-Zafrilla, Pilar López-Román, Francisco Javier |
| author_facet | Pérez-Piñero, Silvia Ávila-Gandía, Vicente Rubio Arias, Jacobo Ángel Muñoz-Carrillo, Juan Carlos Losada-Zafrilla, Pilar López-Román, Francisco Javier |
| author_sort | Pérez-Piñero, Silvia |
| collection | DSpace |
| description | The aim of a 12-week randomized double-blind placebo-controlled study was to assess the effect of daily supplementation with a natural extract of Spinacia oleracea L. (4 × 500 mg capsules/day; total 2 g per day) combined with a moderate-intensity training program (1 h session/3 times a week) on skeletal muscle fitness in adults over 50 years of age. Muscle strength assessed by isokinetic and isometric dynamometry improved significantly in the experimental (n = 23) and the placebo (n = 22) groups, but the magnitude of improvement was higher in the experimental group, with between-group differences in almost all variables, including isokinetic at 60° s−1 in knee extension, peak torque (p < 0.007); total work per repetition maximum (p < 0.009); isokinetic at 180°s−1 in knee extension, peak torque (p < 0.002); total work (p < 0.007); total work per repetition maximum (p < 0.005); average power (p < 0.027); isometric in knee extension, peak torque (p < 0.005); and average peak torque (p < 0.002). Similar findings were observed for muscle quality. Changes in quality of life (SF-36) were not found, except for improvements in the role physical (p < 0.023) and role emotional (p < 0.001) domains, likely as a result of the physical training sessions. A nutritional survey did not revealed changes in dietary habits. No adverse events were recorded. In subjects over 50 years of age, moderate-intensity strength training combined with daily supplementation for 12 weeks with a natural extract of Spinacia oleracea L. improved muscle-related variables and muscle quality. Maintaining muscle health is a key component of healthy aging. |
| format | info:eu-repo/semantics/article |
| id | oai:repositorio.ual.es:10835-13106 |
| institution | Universidad de Cuenca |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oai:repositorio.ual.es:10835-131062023-04-12T19:13:00Z A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial, Evaluating the Effect of Supplementation with a Spinach Extract on Skeletal Muscle Fitness in Adults Older Than 50 Years of Age Pérez-Piñero, Silvia Ávila-Gandía, Vicente Rubio Arias, Jacobo Ángel Muñoz-Carrillo, Juan Carlos Losada-Zafrilla, Pilar López-Román, Francisco Javier natural spinach extract healthy aging muscle health randomized trial strength training The aim of a 12-week randomized double-blind placebo-controlled study was to assess the effect of daily supplementation with a natural extract of Spinacia oleracea L. (4 × 500 mg capsules/day; total 2 g per day) combined with a moderate-intensity training program (1 h session/3 times a week) on skeletal muscle fitness in adults over 50 years of age. Muscle strength assessed by isokinetic and isometric dynamometry improved significantly in the experimental (n = 23) and the placebo (n = 22) groups, but the magnitude of improvement was higher in the experimental group, with between-group differences in almost all variables, including isokinetic at 60° s−1 in knee extension, peak torque (p < 0.007); total work per repetition maximum (p < 0.009); isokinetic at 180°s−1 in knee extension, peak torque (p < 0.002); total work (p < 0.007); total work per repetition maximum (p < 0.005); average power (p < 0.027); isometric in knee extension, peak torque (p < 0.005); and average peak torque (p < 0.002). Similar findings were observed for muscle quality. Changes in quality of life (SF-36) were not found, except for improvements in the role physical (p < 0.023) and role emotional (p < 0.001) domains, likely as a result of the physical training sessions. A nutritional survey did not revealed changes in dietary habits. No adverse events were recorded. In subjects over 50 years of age, moderate-intensity strength training combined with daily supplementation for 12 weeks with a natural extract of Spinacia oleracea L. improved muscle-related variables and muscle quality. Maintaining muscle health is a key component of healthy aging. 2021-12-16T18:37:54Z 2021-12-16T18:37:54Z 2021-12-06 info:eu-repo/semantics/article 2072-6643 http://hdl.handle.net/10835/13106 10.3390/nu13124373 en https://www.mdpi.com/2072-6643/13/12/4373 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess MDPI |
| spellingShingle | natural spinach extract healthy aging muscle health randomized trial strength training Pérez-Piñero, Silvia Ávila-Gandía, Vicente Rubio Arias, Jacobo Ángel Muñoz-Carrillo, Juan Carlos Losada-Zafrilla, Pilar López-Román, Francisco Javier A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial, Evaluating the Effect of Supplementation with a Spinach Extract on Skeletal Muscle Fitness in Adults Older Than 50 Years of Age |
| title | A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial, Evaluating the Effect of Supplementation with a Spinach Extract on Skeletal Muscle Fitness in Adults Older Than 50 Years of Age |
| title_full | A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial, Evaluating the Effect of Supplementation with a Spinach Extract on Skeletal Muscle Fitness in Adults Older Than 50 Years of Age |
| title_fullStr | A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial, Evaluating the Effect of Supplementation with a Spinach Extract on Skeletal Muscle Fitness in Adults Older Than 50 Years of Age |
| title_full_unstemmed | A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial, Evaluating the Effect of Supplementation with a Spinach Extract on Skeletal Muscle Fitness in Adults Older Than 50 Years of Age |
| title_short | A 12-Week Randomized Double-Blind Placebo-Controlled Clinical Trial, Evaluating the Effect of Supplementation with a Spinach Extract on Skeletal Muscle Fitness in Adults Older Than 50 Years of Age |
| title_sort | 12-week randomized double-blind placebo-controlled clinical trial, evaluating the effect of supplementation with a spinach extract on skeletal muscle fitness in adults older than 50 years of age |
| topic | natural spinach extract healthy aging muscle health randomized trial strength training |
| url | http://hdl.handle.net/10835/13106 |
| work_keys_str_mv | AT perezpinerosilvia a12weekrandomizeddoubleblindplacebocontrolledclinicaltrialevaluatingtheeffectofsupplementationwithaspinachextractonskeletalmusclefitnessinadultsolderthan50yearsofage AT avilagandiavicente a12weekrandomizeddoubleblindplacebocontrolledclinicaltrialevaluatingtheeffectofsupplementationwithaspinachextractonskeletalmusclefitnessinadultsolderthan50yearsofage AT rubioariasjacoboangel a12weekrandomizeddoubleblindplacebocontrolledclinicaltrialevaluatingtheeffectofsupplementationwithaspinachextractonskeletalmusclefitnessinadultsolderthan50yearsofage AT munozcarrillojuancarlos a12weekrandomizeddoubleblindplacebocontrolledclinicaltrialevaluatingtheeffectofsupplementationwithaspinachextractonskeletalmusclefitnessinadultsolderthan50yearsofage AT losadazafrillapilar a12weekrandomizeddoubleblindplacebocontrolledclinicaltrialevaluatingtheeffectofsupplementationwithaspinachextractonskeletalmusclefitnessinadultsolderthan50yearsofage AT lopezromanfranciscojavier a12weekrandomizeddoubleblindplacebocontrolledclinicaltrialevaluatingtheeffectofsupplementationwithaspinachextractonskeletalmusclefitnessinadultsolderthan50yearsofage AT perezpinerosilvia 12weekrandomizeddoubleblindplacebocontrolledclinicaltrialevaluatingtheeffectofsupplementationwithaspinachextractonskeletalmusclefitnessinadultsolderthan50yearsofage AT avilagandiavicente 12weekrandomizeddoubleblindplacebocontrolledclinicaltrialevaluatingtheeffectofsupplementationwithaspinachextractonskeletalmusclefitnessinadultsolderthan50yearsofage AT rubioariasjacoboangel 12weekrandomizeddoubleblindplacebocontrolledclinicaltrialevaluatingtheeffectofsupplementationwithaspinachextractonskeletalmusclefitnessinadultsolderthan50yearsofage AT munozcarrillojuancarlos 12weekrandomizeddoubleblindplacebocontrolledclinicaltrialevaluatingtheeffectofsupplementationwithaspinachextractonskeletalmusclefitnessinadultsolderthan50yearsofage AT losadazafrillapilar 12weekrandomizeddoubleblindplacebocontrolledclinicaltrialevaluatingtheeffectofsupplementationwithaspinachextractonskeletalmusclefitnessinadultsolderthan50yearsofage AT lopezromanfranciscojavier 12weekrandomizeddoubleblindplacebocontrolledclinicaltrialevaluatingtheeffectofsupplementationwithaspinachextractonskeletalmusclefitnessinadultsolderthan50yearsofage |