Marine Terpenic Endoperoxides
Organic extracts of marine invertebrates, mainly sponges, from seas all over the world are well known for their high in vitro anticancer and antibiotic activities which make them promising sources of compounds with potential use as pharmaceutical leads. Most of the structures discovered so far have...
| Main Authors: | , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
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MDPI
2021
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10835/13107 |
| _version_ | 1789406335278776320 |
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| author | Torres García, Irene López Martínez, Josefa Leticia Muñoz Dorado, Manuel Rodríguez García, Ignacio Manuel Álvarez Corral, Míriam |
| author_facet | Torres García, Irene López Martínez, Josefa Leticia Muñoz Dorado, Manuel Rodríguez García, Ignacio Manuel Álvarez Corral, Míriam |
| author_sort | Torres García, Irene |
| collection | DSpace |
| description | Organic extracts of marine invertebrates, mainly sponges, from seas all over the world are well known for their high in vitro anticancer and antibiotic activities which make them promising sources of compounds with potential use as pharmaceutical leads. Most of the structures discovered so far have a peculiar structural feature in common: a 1,2-dioxane ring. This is a highly reactive heterocycle that can be considered as an endoperoxide function. Together with other structural features, this group could be responsible for the strong biological activities of the substances present in the extracts. Numerous research programs have focused on their structural elucidation and total synthesis since the seventies. As a consequence, the number of established chiral centres and the similarity between different naturally occurring substances is increasingly higher. Most of these compounds have a terpenoid nature, mainly diterpene and sesterterpene, with several peculiar structural features, such as the loss of one carbon atom. Although there are many reviews dealing with the occurrence of marine peroxides, their activities, or potential pharmaceutical uses, no one has focused on those having a terpene origin and the endoperoxide function. We present here a comprehensive review of these compounds paying special attention to their structural features and their biological activity. |
| format | info:eu-repo/semantics/article |
| id | oai:repositorio.ual.es:10835-13107 |
| institution | Universidad de Cuenca |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oai:repositorio.ual.es:10835-131072023-10-27T12:10:57Z Marine Terpenic Endoperoxides Torres García, Irene López Martínez, Josefa Leticia Muñoz Dorado, Manuel Rodríguez García, Ignacio Manuel Álvarez Corral, Míriam marine terpenoid endoperoxide norseterterpene norditerpene sponge Organic extracts of marine invertebrates, mainly sponges, from seas all over the world are well known for their high in vitro anticancer and antibiotic activities which make them promising sources of compounds with potential use as pharmaceutical leads. Most of the structures discovered so far have a peculiar structural feature in common: a 1,2-dioxane ring. This is a highly reactive heterocycle that can be considered as an endoperoxide function. Together with other structural features, this group could be responsible for the strong biological activities of the substances present in the extracts. Numerous research programs have focused on their structural elucidation and total synthesis since the seventies. As a consequence, the number of established chiral centres and the similarity between different naturally occurring substances is increasingly higher. Most of these compounds have a terpenoid nature, mainly diterpene and sesterterpene, with several peculiar structural features, such as the loss of one carbon atom. Although there are many reviews dealing with the occurrence of marine peroxides, their activities, or potential pharmaceutical uses, no one has focused on those having a terpene origin and the endoperoxide function. We present here a comprehensive review of these compounds paying special attention to their structural features and their biological activity. 2021-12-16T18:38:04Z 2021-12-16T18:38:04Z 2021-11-25 info:eu-repo/semantics/article 1660-3397 http://hdl.handle.net/10835/13107 10.3390/md19120661 en https://www.mdpi.com/1660-3397/19/12/661 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess MDPI |
| spellingShingle | marine terpenoid endoperoxide norseterterpene norditerpene sponge Torres García, Irene López Martínez, Josefa Leticia Muñoz Dorado, Manuel Rodríguez García, Ignacio Manuel Álvarez Corral, Míriam Marine Terpenic Endoperoxides |
| title | Marine Terpenic Endoperoxides |
| title_full | Marine Terpenic Endoperoxides |
| title_fullStr | Marine Terpenic Endoperoxides |
| title_full_unstemmed | Marine Terpenic Endoperoxides |
| title_short | Marine Terpenic Endoperoxides |
| title_sort | marine terpenic endoperoxides |
| topic | marine terpenoid endoperoxide norseterterpene norditerpene sponge |
| url | http://hdl.handle.net/10835/13107 |
| work_keys_str_mv | AT torresgarciairene marineterpenicendoperoxides AT lopezmartinezjosefaleticia marineterpenicendoperoxides AT munozdoradomanuel marineterpenicendoperoxides AT rodriguezgarciaignaciomanuel marineterpenicendoperoxides AT alvarezcorralmiriam marineterpenicendoperoxides |