Porous Metal–Organic Framework Nanoparticles
Metal–organic frameworks (MOFs) are hybrid crystalline particles composed of metal cations and organic linkers. Ranging from micro- to nanoscale depending on the preparation conditions, they have achieved a prevalent position among porous materials. The fact that varying either the metal cation or t...
| Main Authors: | , |
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
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MDPI
2022
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| Online Access: | http://hdl.handle.net/10835/13245 |
| _version_ | 1789406530238414848 |
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| author | Casas Solvas, Juan Manuel Vargas Berenguel, Antonio |
| author_facet | Casas Solvas, Juan Manuel Vargas Berenguel, Antonio |
| author_sort | Casas Solvas, Juan Manuel |
| collection | DSpace |
| description | Metal–organic frameworks (MOFs) are hybrid crystalline particles composed of metal cations and organic linkers. Ranging from micro- to nanoscale depending on the preparation conditions, they have achieved a prevalent position among porous materials. The fact that varying either the metal cation or the organic component leads to a wide range of pore sizes and structures has made them very appealing materials in a broad variety of fields, including gas storage, heterogeneus catalysis, separation, imaging, biosensing, agriculture, and biomedicine.
By optimizing the internal pore volume, many molecules of different natures can be accommodated within the matrix. For instance, the anticancer drug doxorubicin is well known to enter within iron trimesate MIL-100(Fe) nanoMOF. However, the use of this inclusion complex in biomedicine requires the controlled release of the drug. As reported in one of the articles within this Special Issue [1], this goal can be achieved either by modifying the way the drug is loaded into the MOF or by noncovalently coating the surface with appropriate biocompatible materials. Furthermore, the latter can also lead to a higher colloidal stability of the particles. The innovative use of the ssNMR technique on these inclusion complexes associated with a selective isotope labeling strategy gave the authors deeper insights into both the structure of the complexes as well as to the drug release rates and mechanism. |
| format | info:eu-repo/semantics/article |
| id | oai:repositorio.ual.es:10835-13245 |
| institution | Universidad de Cuenca |
| language | English |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oai:repositorio.ual.es:10835-132452023-04-12T19:47:28Z Porous Metal–Organic Framework Nanoparticles Casas Solvas, Juan Manuel Vargas Berenguel, Antonio Metal–organic frameworks (MOFs) are hybrid crystalline particles composed of metal cations and organic linkers. Ranging from micro- to nanoscale depending on the preparation conditions, they have achieved a prevalent position among porous materials. The fact that varying either the metal cation or the organic component leads to a wide range of pore sizes and structures has made them very appealing materials in a broad variety of fields, including gas storage, heterogeneus catalysis, separation, imaging, biosensing, agriculture, and biomedicine. By optimizing the internal pore volume, many molecules of different natures can be accommodated within the matrix. For instance, the anticancer drug doxorubicin is well known to enter within iron trimesate MIL-100(Fe) nanoMOF. However, the use of this inclusion complex in biomedicine requires the controlled release of the drug. As reported in one of the articles within this Special Issue [1], this goal can be achieved either by modifying the way the drug is loaded into the MOF or by noncovalently coating the surface with appropriate biocompatible materials. Furthermore, the latter can also lead to a higher colloidal stability of the particles. The innovative use of the ssNMR technique on these inclusion complexes associated with a selective isotope labeling strategy gave the authors deeper insights into both the structure of the complexes as well as to the drug release rates and mechanism. 2022-02-10T18:18:40Z 2022-02-10T18:18:40Z 2022-02-03 info:eu-repo/semantics/article 2079-4991 http://hdl.handle.net/10835/13245 10.3390/nano12030527 en https://www.mdpi.com/2079-4991/12/3/527/htm Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess MDPI |
| spellingShingle | Casas Solvas, Juan Manuel Vargas Berenguel, Antonio Porous Metal–Organic Framework Nanoparticles |
| title | Porous Metal–Organic Framework Nanoparticles |
| title_full | Porous Metal–Organic Framework Nanoparticles |
| title_fullStr | Porous Metal–Organic Framework Nanoparticles |
| title_full_unstemmed | Porous Metal–Organic Framework Nanoparticles |
| title_short | Porous Metal–Organic Framework Nanoparticles |
| title_sort | porous metal–organic framework nanoparticles |
| url | http://hdl.handle.net/10835/13245 |
| work_keys_str_mv | AT casassolvasjuanmanuel porousmetalorganicframeworknanoparticles AT vargasberenguelantonio porousmetalorganicframeworknanoparticles |