Gallic Acid: A Natural Phenolic Compound Exerting Antitumoral Activities in Colorectal Cancer via Interaction with G-Quadruplexes
Natural phenolic compounds have gained momentum for the prevention and treatment of cancer, but their antitumoral mechanism of action is not yet well understood. In the present study, we screened the antitumoral potential of several phenolic compounds in a cellular model of colorectal cancer (CRC)....
| Main Authors: | , , , , , , , , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
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MDPI
2022
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| Online Access: | http://repositorio.ual.es/handle/10835/13714 |
| _version_ | 1789406337392705536 |
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| author | Sánchez Martín, Victoria Plaza-Calonge, María del Carmen Soriano-Lerma, Ana Ortiz González, Matilde Linde Rodríguez, Ángel Perez-Carrasco, Virginia Ramírez Macías, María Inmaculada Cuadros, Marta Gutierrez-Fernandez, Jose Murciano-Calles, Javier Rodríguez-Manzaneque, Juan Carlos Soriano Rodríguez, Miguel García Salcedo, José Antonio |
| author_facet | Sánchez Martín, Victoria Plaza-Calonge, María del Carmen Soriano-Lerma, Ana Ortiz González, Matilde Linde Rodríguez, Ángel Perez-Carrasco, Virginia Ramírez Macías, María Inmaculada Cuadros, Marta Gutierrez-Fernandez, Jose Murciano-Calles, Javier Rodríguez-Manzaneque, Juan Carlos Soriano Rodríguez, Miguel García Salcedo, José Antonio |
| author_sort | Sánchez Martín, Victoria |
| collection | DSpace |
| description | Natural phenolic compounds have gained momentum for the prevention and treatment of cancer, but their antitumoral mechanism of action is not yet well understood. In the present study, we screened the antitumoral potential of several phenolic compounds in a cellular model of colorectal cancer (CRC). We selected gallic acid (GA) as a candidate in terms of potency and selectivity and extensively evaluated its biological activity. We report on the role of GA as a ligand of DNA G-quadruplexes (G4s), explaining several of its antitumoral effects, including the transcriptional inhibition of ribosomal and CMYC genes. In addition, GA shared with other established G4 ligands some effects such as cell cycle arrest, nucleolar stress, and induction of DNA damage. We further confirmed the antitumoral and G4-stabilizing properties of GA using a xenograft model of CRC. Finally, we succinctly demonstrate that GA could be explored as a therapeutic agent in a patient cohort with CRC. Our work reveals that GA, a natural bioactive compound present in the diet, affects gene expression by interaction with G4s both in vitro and in vivo and paves the way towards G4s targeting with phenolic compounds. |
| format | info:eu-repo/semantics/article |
| id | oai:repositorio.ual.es:10835-13714 |
| institution | Universidad de Cuenca |
| language | English |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oai:repositorio.ual.es:10835-137142023-04-12T18:53:19Z Gallic Acid: A Natural Phenolic Compound Exerting Antitumoral Activities in Colorectal Cancer via Interaction with G-Quadruplexes Sánchez Martín, Victoria Plaza-Calonge, María del Carmen Soriano-Lerma, Ana Ortiz González, Matilde Linde Rodríguez, Ángel Perez-Carrasco, Virginia Ramírez Macías, María Inmaculada Cuadros, Marta Gutierrez-Fernandez, Jose Murciano-Calles, Javier Rodríguez-Manzaneque, Juan Carlos Soriano Rodríguez, Miguel García Salcedo, José Antonio G-quadruplex phenol gallic acid cancer colorectal cancer Natural phenolic compounds have gained momentum for the prevention and treatment of cancer, but their antitumoral mechanism of action is not yet well understood. In the present study, we screened the antitumoral potential of several phenolic compounds in a cellular model of colorectal cancer (CRC). We selected gallic acid (GA) as a candidate in terms of potency and selectivity and extensively evaluated its biological activity. We report on the role of GA as a ligand of DNA G-quadruplexes (G4s), explaining several of its antitumoral effects, including the transcriptional inhibition of ribosomal and CMYC genes. In addition, GA shared with other established G4 ligands some effects such as cell cycle arrest, nucleolar stress, and induction of DNA damage. We further confirmed the antitumoral and G4-stabilizing properties of GA using a xenograft model of CRC. Finally, we succinctly demonstrate that GA could be explored as a therapeutic agent in a patient cohort with CRC. Our work reveals that GA, a natural bioactive compound present in the diet, affects gene expression by interaction with G4s both in vitro and in vivo and paves the way towards G4s targeting with phenolic compounds. 2022-06-01T17:04:36Z 2022-06-01T17:04:36Z 2022-05-26 info:eu-repo/semantics/article 2072-6694 http://repositorio.ual.es/handle/10835/13714 10.3390/cancers14112648 en https://www.mdpi.com/2072-6694/14/11/2648 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess MDPI |
| spellingShingle | G-quadruplex phenol gallic acid cancer colorectal cancer Sánchez Martín, Victoria Plaza-Calonge, María del Carmen Soriano-Lerma, Ana Ortiz González, Matilde Linde Rodríguez, Ángel Perez-Carrasco, Virginia Ramírez Macías, María Inmaculada Cuadros, Marta Gutierrez-Fernandez, Jose Murciano-Calles, Javier Rodríguez-Manzaneque, Juan Carlos Soriano Rodríguez, Miguel García Salcedo, José Antonio Gallic Acid: A Natural Phenolic Compound Exerting Antitumoral Activities in Colorectal Cancer via Interaction with G-Quadruplexes |
| title | Gallic Acid: A Natural Phenolic Compound Exerting Antitumoral Activities in Colorectal Cancer via Interaction with G-Quadruplexes |
| title_full | Gallic Acid: A Natural Phenolic Compound Exerting Antitumoral Activities in Colorectal Cancer via Interaction with G-Quadruplexes |
| title_fullStr | Gallic Acid: A Natural Phenolic Compound Exerting Antitumoral Activities in Colorectal Cancer via Interaction with G-Quadruplexes |
| title_full_unstemmed | Gallic Acid: A Natural Phenolic Compound Exerting Antitumoral Activities in Colorectal Cancer via Interaction with G-Quadruplexes |
| title_short | Gallic Acid: A Natural Phenolic Compound Exerting Antitumoral Activities in Colorectal Cancer via Interaction with G-Quadruplexes |
| title_sort | gallic acid: a natural phenolic compound exerting antitumoral activities in colorectal cancer via interaction with g-quadruplexes |
| topic | G-quadruplex phenol gallic acid cancer colorectal cancer |
| url | http://repositorio.ual.es/handle/10835/13714 |
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