Effective method for a graphene oxide with impressive selectivity in carboxyl groups
The development of new applications of graphene oxide in the biomedical field requires the covalent bonding of bioactive molecules to a sheet skeleton. Obtaining a large carboxyl group population over the surface is one of the main targets, as carboxyl group concentration in conventional graphene ox...
| Main Authors: | , , , , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
| Published: |
MDPI
2022
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10835/13990 |
| _version_ | 1789406357768634368 |
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| author | Rodríguez Pastor, Iluminada López-Pérez, Adelia Romero-Sanchez, Maria Dolores Perez, Juana María Fernandez De Las Nieves, Ignacio Martin-Gullon, Ignacio |
| author_facet | Rodríguez Pastor, Iluminada López-Pérez, Adelia Romero-Sanchez, Maria Dolores Perez, Juana María Fernandez De Las Nieves, Ignacio Martin-Gullon, Ignacio |
| author_sort | Rodríguez Pastor, Iluminada |
| collection | DSpace |
| description | The development of new applications of graphene oxide in the biomedical field requires the covalent bonding of bioactive molecules to a sheet skeleton. Obtaining a large carboxyl group population over the surface is one of the main targets, as carboxyl group concentration in conventional graphene oxide is low among a majority of non-useful sp3-C-based functionalities. In the present work, we propose a selective method that yields an impressive increase in carboxyl group population using single-layer, thermally reduced graphene oxide as a precursor in a conventional Hummers–Offemann reaction. When starting with a reduced graphene oxide with no interlayer registry, sulfuric acid cannot form a graphite intercalated compound. Then, potassium permanganate attacks in in-plane (vacancies or holes) structural defects, which are numerous over a thermally reduced graphene oxide, as well as in edges, yielding majorly carboxyl groups without sheet cutting and unzipping, as no carbon dot formation was observed. A single-layer precursor with no ordered stacking prevents the formation of an intercalated compound, and it is this mechanism of the potassium permanganate that results in carboxyl group formation and the hydrophilic character of the compound. |
| format | info:eu-repo/semantics/article |
| id | oai:repositorio.ual.es:10835-13990 |
| institution | Universidad de Cuenca |
| language | English |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oai:repositorio.ual.es:10835-139902023-04-12T19:47:03Z Effective method for a graphene oxide with impressive selectivity in carboxyl groups Rodríguez Pastor, Iluminada López-Pérez, Adelia Romero-Sanchez, Maria Dolores Perez, Juana María Fernandez De Las Nieves, Ignacio Martin-Gullon, Ignacio reduced graphene oxide graphite intercalated compound carboxyl groups bioconjugation The development of new applications of graphene oxide in the biomedical field requires the covalent bonding of bioactive molecules to a sheet skeleton. Obtaining a large carboxyl group population over the surface is one of the main targets, as carboxyl group concentration in conventional graphene oxide is low among a majority of non-useful sp3-C-based functionalities. In the present work, we propose a selective method that yields an impressive increase in carboxyl group population using single-layer, thermally reduced graphene oxide as a precursor in a conventional Hummers–Offemann reaction. When starting with a reduced graphene oxide with no interlayer registry, sulfuric acid cannot form a graphite intercalated compound. Then, potassium permanganate attacks in in-plane (vacancies or holes) structural defects, which are numerous over a thermally reduced graphene oxide, as well as in edges, yielding majorly carboxyl groups without sheet cutting and unzipping, as no carbon dot formation was observed. A single-layer precursor with no ordered stacking prevents the formation of an intercalated compound, and it is this mechanism of the potassium permanganate that results in carboxyl group formation and the hydrophilic character of the compound. 2022-09-22T11:00:41Z 2022-09-22T11:00:41Z 2022-09-08 info:eu-repo/semantics/article 2079-4991 http://hdl.handle.net/10835/13990 10.3390/nano12183112 en https://www.mdpi.com/2079-4991/12/18/3112 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess MDPI |
| spellingShingle | reduced graphene oxide graphite intercalated compound carboxyl groups bioconjugation Rodríguez Pastor, Iluminada López-Pérez, Adelia Romero-Sanchez, Maria Dolores Perez, Juana María Fernandez De Las Nieves, Ignacio Martin-Gullon, Ignacio Effective method for a graphene oxide with impressive selectivity in carboxyl groups |
| title | Effective method for a graphene oxide with impressive selectivity in carboxyl groups |
| title_full | Effective method for a graphene oxide with impressive selectivity in carboxyl groups |
| title_fullStr | Effective method for a graphene oxide with impressive selectivity in carboxyl groups |
| title_full_unstemmed | Effective method for a graphene oxide with impressive selectivity in carboxyl groups |
| title_short | Effective method for a graphene oxide with impressive selectivity in carboxyl groups |
| title_sort | effective method for a graphene oxide with impressive selectivity in carboxyl groups |
| topic | reduced graphene oxide graphite intercalated compound carboxyl groups bioconjugation |
| url | http://hdl.handle.net/10835/13990 |
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