The Relevance of GIRK Channels in Heart Function
Among the large number of potassium-channel families implicated in the control of neuronal excitability, G-protein-gated inwardly rectifying potassium channels (GIRK/Kir3) have been found to be a main factor in heart control. These channels are activated following the modulation of G-protein-coupled...
| Main Authors: | , , |
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
| Published: |
MDPI
2022
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10835/14090 |
| _version_ | 1789408411529510912 |
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| author | Campos-Ríos, Ana Rueda Ruzafa, Lola Lamas, José Antonio |
| author_facet | Campos-Ríos, Ana Rueda Ruzafa, Lola Lamas, José Antonio |
| author_sort | Campos-Ríos, Ana |
| collection | DSpace |
| description | Among the large number of potassium-channel families implicated in the control of neuronal excitability, G-protein-gated inwardly rectifying potassium channels (GIRK/Kir3) have been found to be a main factor in heart control. These channels are activated following the modulation of G-protein-coupled receptors and, although they have been implicated in different neurological diseases in both human and animal studies of the central nervous system, the therapeutic potential of different subtypes of these channel families in cardiac conditions has remained untapped. As they have emerged as a promising potential tool to treat a variety of conditions that disrupt neuronal homeostasis, many studies have started to focus on these channels as mediators of cardiac dynamics, thus leading to research into their implication in cardiovascular conditions. Our aim is to review the latest advances in GIRK modulation in the heart and their role in the cardiovascular system. |
| format | info:eu-repo/semantics/article |
| id | oai:repositorio.ual.es:10835-14090 |
| institution | Universidad de Cuenca |
| language | English |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oai:repositorio.ual.es:10835-140902023-04-12T19:19:50Z The Relevance of GIRK Channels in Heart Function Campos-Ríos, Ana Rueda Ruzafa, Lola Lamas, José Antonio heart GIRK channel IK ACh G-protein-coupled receptor Among the large number of potassium-channel families implicated in the control of neuronal excitability, G-protein-gated inwardly rectifying potassium channels (GIRK/Kir3) have been found to be a main factor in heart control. These channels are activated following the modulation of G-protein-coupled receptors and, although they have been implicated in different neurological diseases in both human and animal studies of the central nervous system, the therapeutic potential of different subtypes of these channel families in cardiac conditions has remained untapped. As they have emerged as a promising potential tool to treat a variety of conditions that disrupt neuronal homeostasis, many studies have started to focus on these channels as mediators of cardiac dynamics, thus leading to research into their implication in cardiovascular conditions. Our aim is to review the latest advances in GIRK modulation in the heart and their role in the cardiovascular system. 2022-11-16T19:19:15Z 2022-11-16T19:19:15Z 2022-11-09 info:eu-repo/semantics/article 2077-0375 http://hdl.handle.net/10835/14090 10.3390/membranes12111119 en https://www.mdpi.com/2077-0375/12/11/1119 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess MDPI |
| spellingShingle | heart GIRK channel IK ACh G-protein-coupled receptor Campos-Ríos, Ana Rueda Ruzafa, Lola Lamas, José Antonio The Relevance of GIRK Channels in Heart Function |
| title | The Relevance of GIRK Channels in Heart Function |
| title_full | The Relevance of GIRK Channels in Heart Function |
| title_fullStr | The Relevance of GIRK Channels in Heart Function |
| title_full_unstemmed | The Relevance of GIRK Channels in Heart Function |
| title_short | The Relevance of GIRK Channels in Heart Function |
| title_sort | relevance of girk channels in heart function |
| topic | heart GIRK channel IK ACh G-protein-coupled receptor |
| url | http://hdl.handle.net/10835/14090 |
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