DIRECT MECHANICAL THROMBECTOMY VERSUS BRIDGING THERAPY FOR STROKE PATIENTS IN A SOUTHERN EUROPEAN "STROKE BELT".
The aim of this 4-year observational study is to analyze the outcomes of stroke patients treated with direct mechanical thrombectomy (dMT) compared to bridging therapy (BT) (intravenous thrombolysis [IVT] + BT) based on 3-month outcomes, in real clinical practice in the "Stroke Belt" of So...
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| Format: | info:eu-repo/semantics/article |
| Language: | English |
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MDPI
2023
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| Online Access: | http://hdl.handle.net/10835/14409 |
| _version_ | 1789408389650972672 |
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| author | Toro-Pérez, Cristina Del Amaya Pascasio, Laura Guevara-Sánchez, Eva Ruiz-Franco, Maria Luisa Arjona Padillo, Antonio Martínez Sánchez, Patricia |
| author_facet | Toro-Pérez, Cristina Del Amaya Pascasio, Laura Guevara-Sánchez, Eva Ruiz-Franco, Maria Luisa Arjona Padillo, Antonio Martínez Sánchez, Patricia |
| author_sort | Toro-Pérez, Cristina Del |
| collection | DSpace |
| description | The aim of this 4-year observational study is to analyze the outcomes of stroke patients treated with direct mechanical thrombectomy (dMT) compared to bridging therapy (BT) (intravenous thrombolysis [IVT] + BT) based on 3-month outcomes, in real clinical practice in the "Stroke Belt" of Southern Europe. In total, 300 patients were included (41.3% dMT and 58.6% BT). The frequency of direct referral to the stroke center was similar in the dMT and BT group, whereas the time from onset to groin was longer in the BT group (median 210 [IQR 160–303] vs. 399 [IQR 225–675], p = 0.001). Successful recanalization (TICI 2b-3) and hemorrhagic transformation were similar in both groups. The BT group more frequently showed excellent outcomes at 3 months (32.4% vs. 15.4%, p = 0.004). Multivariate analysis showed that BT was independently associated with excellent outcomes (OR 2.7. 95% CI,1.2–5.9, p = 0.02) and lower mortality (OR 0.36. 95% CI 0.16–0.82, p = 015). Conclusions: Compared with dMT, BT was associated with excellent functional outcomes and lower 3-month mortality in this real-world clinical practice study conducted in a region belonging to the “Stroke Belt” of Southern Europe. Given the disparity of results on the benefit of BT in the current evidence, it is of vital importance to analyze the convenience of its use in each health area. |
| format | info:eu-repo/semantics/article |
| id | oai:repositorio.ual.es:10835-14409 |
| institution | Universidad de Cuenca |
| language | English |
| publishDate | 2023 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oai:repositorio.ual.es:10835-144092023-10-30T14:04:50Z DIRECT MECHANICAL THROMBECTOMY VERSUS BRIDGING THERAPY FOR STROKE PATIENTS IN A SOUTHERN EUROPEAN "STROKE BELT". Toro-Pérez, Cristina Del Amaya Pascasio, Laura Guevara-Sánchez, Eva Ruiz-Franco, Maria Luisa Arjona Padillo, Antonio Martínez Sánchez, Patricia direct mechanical thrombectomy bridging therapy intravenous thrombolysis acute ischemic stroke stroke belt transfer model The aim of this 4-year observational study is to analyze the outcomes of stroke patients treated with direct mechanical thrombectomy (dMT) compared to bridging therapy (BT) (intravenous thrombolysis [IVT] + BT) based on 3-month outcomes, in real clinical practice in the "Stroke Belt" of Southern Europe. In total, 300 patients were included (41.3% dMT and 58.6% BT). The frequency of direct referral to the stroke center was similar in the dMT and BT group, whereas the time from onset to groin was longer in the BT group (median 210 [IQR 160–303] vs. 399 [IQR 225–675], p = 0.001). Successful recanalization (TICI 2b-3) and hemorrhagic transformation were similar in both groups. The BT group more frequently showed excellent outcomes at 3 months (32.4% vs. 15.4%, p = 0.004). Multivariate analysis showed that BT was independently associated with excellent outcomes (OR 2.7. 95% CI,1.2–5.9, p = 0.02) and lower mortality (OR 0.36. 95% CI 0.16–0.82, p = 015). Conclusions: Compared with dMT, BT was associated with excellent functional outcomes and lower 3-month mortality in this real-world clinical practice study conducted in a region belonging to the “Stroke Belt” of Southern Europe. Given the disparity of results on the benefit of BT in the current evidence, it is of vital importance to analyze the convenience of its use in each health area. 2023-03-09T13:57:29Z 2023-03-09T13:57:29Z 2023-02-28 info:eu-repo/semantics/article 2075-4426 http://hdl.handle.net/10835/14409 10.3390/jpm13030440 en https://www.mdpi.com/2075-4426/13/3/440 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess MDPI |
| spellingShingle | direct mechanical thrombectomy bridging therapy intravenous thrombolysis acute ischemic stroke stroke belt transfer model Toro-Pérez, Cristina Del Amaya Pascasio, Laura Guevara-Sánchez, Eva Ruiz-Franco, Maria Luisa Arjona Padillo, Antonio Martínez Sánchez, Patricia DIRECT MECHANICAL THROMBECTOMY VERSUS BRIDGING THERAPY FOR STROKE PATIENTS IN A SOUTHERN EUROPEAN "STROKE BELT". |
| title | DIRECT MECHANICAL THROMBECTOMY VERSUS BRIDGING THERAPY FOR STROKE PATIENTS IN A SOUTHERN EUROPEAN "STROKE BELT". |
| title_full | DIRECT MECHANICAL THROMBECTOMY VERSUS BRIDGING THERAPY FOR STROKE PATIENTS IN A SOUTHERN EUROPEAN "STROKE BELT". |
| title_fullStr | DIRECT MECHANICAL THROMBECTOMY VERSUS BRIDGING THERAPY FOR STROKE PATIENTS IN A SOUTHERN EUROPEAN "STROKE BELT". |
| title_full_unstemmed | DIRECT MECHANICAL THROMBECTOMY VERSUS BRIDGING THERAPY FOR STROKE PATIENTS IN A SOUTHERN EUROPEAN "STROKE BELT". |
| title_short | DIRECT MECHANICAL THROMBECTOMY VERSUS BRIDGING THERAPY FOR STROKE PATIENTS IN A SOUTHERN EUROPEAN "STROKE BELT". |
| title_sort | direct mechanical thrombectomy versus bridging therapy for stroke patients in a southern european "stroke belt". |
| topic | direct mechanical thrombectomy bridging therapy intravenous thrombolysis acute ischemic stroke stroke belt transfer model |
| url | http://hdl.handle.net/10835/14409 |
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