Stereoselective Barbier Type Allylations and Propargylations Mediated by CpTiCl3
CpTiCl2, prepared in situ by manganese reduction of CpTiCl3, is an excellent new system for the Barbier-type allylation and propargylation of carbonyl compounds. It can be used in catalytic amounts when combined with Et3N•HBr/TMSBr, which act as regenerating system. The high regio- and stereoselecti...
| Hauptverfasser: | , , , , |
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| Format: | info:eu-repo/semantics/article |
| Sprache: | English |
| Veröffentlicht: |
American Chemical Society
2023
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| Schlagworte: | |
| Online Zugang: | http://hdl.handle.net/10835/14713 https://doi.org/10.1021/acs.joc.8b02643 |
| Zusammenfassung: | CpTiCl2, prepared in situ by manganese reduction of CpTiCl3, is an excellent new system for the Barbier-type allylation and propargylation of carbonyl compounds. It can be used in catalytic amounts when combined with Et3N•HBr/TMSBr, which act as regenerating system. The high regio- and stereoselectivity shown by this system makes it useful for prenylation and crotylation processes in synthesis of natural products. |
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