Ru complexes containing Cp, mPTA and natural purine bases (mPTA = methyl-N-1,3,5-triaza-7-phosphaadamantane): Evaluation of their antiproliferative activity, solubility and redox properties

Ru complexes containing Cp, mPTA and natural purine bases (mPTA = methyl-N-1,3,5-triaza-7-phosphaadamantane): Evaluation of their antiproliferative activity, solubility and redox properties

Complexes [RuCp(Adeninate–κN9)(mPTA)2](Cl0.5)(CF3SO3)2.5⋅H2O (1⋅H2O), [RuCp(Guaninate-κN7)(mPTA)2] (CF3SO3)2⋅H2O (2⋅H2O), [RuCp(Theophyllinate-κN7)(mPTA)2](CF3SO3)2⋅1.5H2O (3⋅1.5H2O) and [RuCp(Pur- κN)(mPTA)(PPh3)](CF3SO3) (4–6) (Pur = Adeninate, Guaninate, Teophyllinate; mPTA = N-methyl 􀀀 1,3,5-t...

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Bibliographic Details
Main Authors: Hajji, Lazhar, Saraiba Bello, Cristóbal, Scalambra, Franco, Segovia Torrente, Gaspar Francisco, Romerosa Nievas, Antonio Manuel
Format: info:eu-repo/semantics/article
Language:English
Published: 2024
Subjects:
Antiproliferative activity
Ruthenium
Water-soluble complexes
mPTA
Natural purines
Online Access:http://hdl.handle.net/10835/15051
Description
Summary:Complexes [RuCp(Adeninate–κN9)(mPTA)2](Cl0.5)(CF3SO3)2.5⋅H2O (1⋅H2O), [RuCp(Guaninate-κN7)(mPTA)2] (CF3SO3)2⋅H2O (2⋅H2O), [RuCp(Theophyllinate-κN7)(mPTA)2](CF3SO3)2⋅1.5H2O (3⋅1.5H2O) and [RuCp(Pur- κN)(mPTA)(PPh3)](CF3SO3) (4–6) (Pur = Adeninate, Guaninate, Teophyllinate; mPTA = N-methyl 􀀀 1,3,5-triaza- 7-phosphaadamantane) have been synthesized and characterized. Structure of complexes 1⋅H2O and 3⋅1.5H2O were determined by single-crystal X-ray diffraction. Solubility in water, Log P, electrochemical properties and antiproliferative activities of the complexes (against cisplatin-sensitive T2 and cisplatin-resistant SKOV3 cell lines) have been assessed and discussed.

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